Murine M290 integrin expression modulated by mast cell activation
Intraepithelial T lymphocytes possess a (TGFP)-inducible integrin complex that consists of the β7 integrin chain in association with a novel a chain, murine αM290. Using antibodies directed against the murine αM290 chain, IL-3-dependent murine bone marrowderived mast cells demonstrated positive stai...
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| Veröffentlicht in: | Immunity (Cambridge, Mass.) Mass.), 1994-08, Vol.1 (5), p.393-403 |
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| container_title | Immunity (Cambridge, Mass.) |
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| creator | Smith, Tracey J. Ducharme, Lori A. Shaw, Sunil K. Parker, Christina M. Brenner, Michael B. Kilshaw, Peter J. Weis, John H. |
| description | Intraepithelial T lymphocytes possess a (TGFP)-inducible integrin complex that consists of the β7 integrin chain in association with a novel a chain, murine αM290. Using antibodies directed against the murine αM290 chain, IL-3-dependent murine bone marrowderived mast cells demonstrated positive staining after induction with TGFβ. Sequence information from the human intraepithelial T lymphocyte-αE gene sequence was used to clone the murine homolog from a TGFβ-induced T cell library. The murine αE homolog gene encodes a protein recognized by antibodies to αM290. Expression of this gene by bone marrowderived mast cells was found to be induced by TGFβ or IgE-mediated cross-linking of FcϵR1. Furthermore, exposure of murine TK-1 cells to supernatants from activated mast cells induces the expression of the αM290 gene, indicating that a mast cell mediator(s) can act in a paracrine manner to induce expression of this integrin complex by other cells. |
| doi_str_mv | 10.1016/1074-7613(94)90070-1 |
| format | Article |
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Using antibodies directed against the murine αM290 chain, IL-3-dependent murine bone marrowderived mast cells demonstrated positive staining after induction with TGFβ. Sequence information from the human intraepithelial T lymphocyte-αE gene sequence was used to clone the murine homolog from a TGFβ-induced T cell library. The murine αE homolog gene encodes a protein recognized by antibodies to αM290. Expression of this gene by bone marrowderived mast cells was found to be induced by TGFβ or IgE-mediated cross-linking of FcϵR1. Furthermore, exposure of murine TK-1 cells to supernatants from activated mast cells induces the expression of the αM290 gene, indicating that a mast cell mediator(s) can act in a paracrine manner to induce expression of this integrin complex by other cells.</description><identifier>ISSN: 1074-7613</identifier><identifier>EISSN: 1097-4180</identifier><identifier>DOI: 10.1016/1074-7613(94)90070-1</identifier><identifier>PMID: 7882170</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Amino Acid Sequence ; Animals ; Base Sequence ; Cell Degranulation ; Gene Expression ; Humans ; Immunoglobulin E - pharmacology ; Integrins - chemistry ; Integrins - genetics ; Mast Cells - immunology ; Mast Cells - physiology ; Mice ; Mice, Inbred BALB C ; Molecular Sequence Data ; Molecular Structure ; Proteins - analysis</subject><ispartof>Immunity (Cambridge, Mass.), 1994-08, Vol.1 (5), p.393-403</ispartof><rights>1994</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-739ec98d29e9e4d1ff52603d5cd79dee851e34608cb3207b971dbc85561ed9f73</citedby><cites>FETCH-LOGICAL-c388t-739ec98d29e9e4d1ff52603d5cd79dee851e34608cb3207b971dbc85561ed9f73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/1074-7613(94)90070-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7882170$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Smith, Tracey J.</creatorcontrib><creatorcontrib>Ducharme, Lori A.</creatorcontrib><creatorcontrib>Shaw, Sunil K.</creatorcontrib><creatorcontrib>Parker, Christina M.</creatorcontrib><creatorcontrib>Brenner, Michael B.</creatorcontrib><creatorcontrib>Kilshaw, Peter J.</creatorcontrib><creatorcontrib>Weis, John H.</creatorcontrib><title>Murine M290 integrin expression modulated by mast cell activation</title><title>Immunity (Cambridge, Mass.)</title><addtitle>Immunity</addtitle><description>Intraepithelial T lymphocytes possess a (TGFP)-inducible integrin complex that consists of the β7 integrin chain in association with a novel a chain, murine αM290. Using antibodies directed against the murine αM290 chain, IL-3-dependent murine bone marrowderived mast cells demonstrated positive staining after induction with TGFβ. Sequence information from the human intraepithelial T lymphocyte-αE gene sequence was used to clone the murine homolog from a TGFβ-induced T cell library. The murine αE homolog gene encodes a protein recognized by antibodies to αM290. Expression of this gene by bone marrowderived mast cells was found to be induced by TGFβ or IgE-mediated cross-linking of FcϵR1. Furthermore, exposure of murine TK-1 cells to supernatants from activated mast cells induces the expression of the αM290 gene, indicating that a mast cell mediator(s) can act in a paracrine manner to induce expression of this integrin complex by other cells.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Cell Degranulation</subject><subject>Gene Expression</subject><subject>Humans</subject><subject>Immunoglobulin E - pharmacology</subject><subject>Integrins - chemistry</subject><subject>Integrins - genetics</subject><subject>Mast Cells - immunology</subject><subject>Mast Cells - physiology</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Molecular Sequence Data</subject><subject>Molecular Structure</subject><subject>Proteins - analysis</subject><issn>1074-7613</issn><issn>1097-4180</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLxDAQgIMoPlb_gUJPoofqTNM2yUVYxBeseNFzaJOpRLbtmrSL--9t3eJRTzPDfPPgY-wU4QoB82sEkcYiR36h0ksFICDGHXaIoEScooTdMZ-QA3YUwgcAppmCfbYvpExQwCGbP_feNRQ9Jwoi13T0PpQRfa08heDaJqpb2y-LjmxUbqK6CF1kaLmMCtO5ddENxDHbq4ploJMpztjb_d3r7WO8eHl4up0vYsOl7GLBFRklbaJIUWqxqrIkB24zY4WyRDJD4mkO0pQ8AVEqgbY0MstyJKsqwWfsfLt35dvPnkKnaxfGX4qG2j5oIUTGufofxHy4JXI-gOkWNL4NwVOlV97Vhd9oBD0q1qM_PfrTKtU_ijUOY2fT_r6syf4OTU6H_s22T4ONtSOvg3HUGLLOk-m0bd3fB74BqDaJsg</recordid><startdate>19940801</startdate><enddate>19940801</enddate><creator>Smith, Tracey J.</creator><creator>Ducharme, Lori A.</creator><creator>Shaw, Sunil K.</creator><creator>Parker, Christina M.</creator><creator>Brenner, Michael B.</creator><creator>Kilshaw, Peter J.</creator><creator>Weis, John H.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19940801</creationdate><title>Murine M290 integrin expression modulated by mast cell activation</title><author>Smith, Tracey J. ; Ducharme, Lori A. ; Shaw, Sunil K. ; Parker, Christina M. ; Brenner, Michael B. ; Kilshaw, Peter J. ; Weis, John H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-739ec98d29e9e4d1ff52603d5cd79dee851e34608cb3207b971dbc85561ed9f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Cell Degranulation</topic><topic>Gene Expression</topic><topic>Humans</topic><topic>Immunoglobulin E - pharmacology</topic><topic>Integrins - chemistry</topic><topic>Integrins - genetics</topic><topic>Mast Cells - immunology</topic><topic>Mast Cells - physiology</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Molecular Sequence Data</topic><topic>Molecular Structure</topic><topic>Proteins - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smith, Tracey J.</creatorcontrib><creatorcontrib>Ducharme, Lori A.</creatorcontrib><creatorcontrib>Shaw, Sunil K.</creatorcontrib><creatorcontrib>Parker, Christina M.</creatorcontrib><creatorcontrib>Brenner, Michael B.</creatorcontrib><creatorcontrib>Kilshaw, Peter J.</creatorcontrib><creatorcontrib>Weis, John H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Immunity (Cambridge, Mass.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smith, Tracey J.</au><au>Ducharme, Lori A.</au><au>Shaw, Sunil K.</au><au>Parker, Christina M.</au><au>Brenner, Michael B.</au><au>Kilshaw, Peter J.</au><au>Weis, John H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Murine M290 integrin expression modulated by mast cell activation</atitle><jtitle>Immunity (Cambridge, Mass.)</jtitle><addtitle>Immunity</addtitle><date>1994-08-01</date><risdate>1994</risdate><volume>1</volume><issue>5</issue><spage>393</spage><epage>403</epage><pages>393-403</pages><issn>1074-7613</issn><eissn>1097-4180</eissn><abstract>Intraepithelial T lymphocytes possess a (TGFP)-inducible integrin complex that consists of the β7 integrin chain in association with a novel a chain, murine αM290. Using antibodies directed against the murine αM290 chain, IL-3-dependent murine bone marrowderived mast cells demonstrated positive staining after induction with TGFβ. Sequence information from the human intraepithelial T lymphocyte-αE gene sequence was used to clone the murine homolog from a TGFβ-induced T cell library. The murine αE homolog gene encodes a protein recognized by antibodies to αM290. Expression of this gene by bone marrowderived mast cells was found to be induced by TGFβ or IgE-mediated cross-linking of FcϵR1. Furthermore, exposure of murine TK-1 cells to supernatants from activated mast cells induces the expression of the αM290 gene, indicating that a mast cell mediator(s) can act in a paracrine manner to induce expression of this integrin complex by other cells.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>7882170</pmid><doi>10.1016/1074-7613(94)90070-1</doi><tpages>11</tpages></addata></record> |
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| ispartof | Immunity (Cambridge, Mass.), 1994-08, Vol.1 (5), p.393-403 |
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| language | eng |
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| source | MEDLINE; Cell Press Free Archives; Access via ScienceDirect (Elsevier) |
| subjects | Amino Acid Sequence Animals Base Sequence Cell Degranulation Gene Expression Humans Immunoglobulin E - pharmacology Integrins - chemistry Integrins - genetics Mast Cells - immunology Mast Cells - physiology Mice Mice, Inbred BALB C Molecular Sequence Data Molecular Structure Proteins - analysis |
| title | Murine M290 integrin expression modulated by mast cell activation |
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