Longitudinal measurement of anticardiolipin antibodies during normal pregnancy: a prospective study
We have previously shown that elevation of anticardiolipin antibodies (aCL) at the first prenatal visit is associated with increased fetal loss in normal pregnancy. The variation in aCL levels during normal pregnancy has not been established. To examine this question we measured IgG, IgM and IgA aCL...
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| Veröffentlicht in: | Lupus 1995-10, Vol.4 (5), p.365-369 |
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| creator | Lynch, AM Rutledge, JH Stephens, JK Murphy, JR Marlar, RA Davila, GH Santos, ME Emlen, W. |
| description | We have previously shown that elevation of anticardiolipin antibodies (aCL) at the first prenatal visit is associated with increased fetal loss in normal pregnancy. The variation in aCL levels during normal pregnancy has not been established. To examine this question we measured IgG, IgM and IgA aCL levels five times during pregnancy at weeks 5-15, 16-25, 26-35, 36-37 and at delivery. Data were analyzed to determine: (a) the within and between subject variability of aCL during pregnancy; (2) the temporal trend of aCL; and (3) the relation of serial measures of aCL with maternal complications of pregnancy.
We divided our cohort of 354 subjects into two groups. Group A included those subjects with consistently normal levels of aCL and group B those subjects with at least one elevated level of aCL. In group A the within subject variability was relatively low (28-34%). In group B we found wide fluctuations in aCL levels and a within subject variability of 88-91 %. Subjects in group B had no increase in maternal complications of pregnancy.
The present data suggest that aCL may fluctuate significantly during normal pregnancy and there is little clinical value in measuring aCL on a serial basis during pregnancy. |
| doi_str_mv | 10.1177/096120339500400506 |
| format | Article |
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We divided our cohort of 354 subjects into two groups. Group A included those subjects with consistently normal levels of aCL and group B those subjects with at least one elevated level of aCL. In group A the within subject variability was relatively low (28-34%). In group B we found wide fluctuations in aCL levels and a within subject variability of 88-91 %. Subjects in group B had no increase in maternal complications of pregnancy.
The present data suggest that aCL may fluctuate significantly during normal pregnancy and there is little clinical value in measuring aCL on a serial basis during pregnancy.</description><identifier>ISSN: 0961-2033</identifier><identifier>EISSN: 1477-0962</identifier><identifier>DOI: 10.1177/096120339500400506</identifier><identifier>PMID: 8563730</identifier><language>eng</language><publisher>Thousand Oaks, CA: SAGE Publications</publisher><subject>Adolescent ; Adult ; Antibodies, Anticardiolipin - blood ; Female ; Humans ; Immunoglobulin A - blood ; Immunoglobulin G - blood ; Immunoglobulin M - blood ; Infant, Newborn ; Infant, Premature ; Labor, Obstetric ; Longitudinal Studies ; Pregnancy - blood ; Pregnancy - immunology ; Pregnancy Complications - blood ; Pregnancy Complications - immunology ; Pregnancy Trimester, First ; Pregnancy Trimester, Second ; Pregnancy Trimester, Third ; Prospective Studies ; Reference Values</subject><ispartof>Lupus, 1995-10, Vol.4 (5), p.365-369</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-572e80f167e611a3c285cddcb62f2101b144957391c43d43ae2f37062c46000c3</citedby><cites>FETCH-LOGICAL-c370t-572e80f167e611a3c285cddcb62f2101b144957391c43d43ae2f37062c46000c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/096120339500400506$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/096120339500400506$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8563730$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lynch, AM</creatorcontrib><creatorcontrib>Rutledge, JH</creatorcontrib><creatorcontrib>Stephens, JK</creatorcontrib><creatorcontrib>Murphy, JR</creatorcontrib><creatorcontrib>Marlar, RA</creatorcontrib><creatorcontrib>Davila, GH</creatorcontrib><creatorcontrib>Santos, ME</creatorcontrib><creatorcontrib>Emlen, W.</creatorcontrib><title>Longitudinal measurement of anticardiolipin antibodies during normal pregnancy: a prospective study</title><title>Lupus</title><addtitle>Lupus</addtitle><description>We have previously shown that elevation of anticardiolipin antibodies (aCL) at the first prenatal visit is associated with increased fetal loss in normal pregnancy. The variation in aCL levels during normal pregnancy has not been established. To examine this question we measured IgG, IgM and IgA aCL levels five times during pregnancy at weeks 5-15, 16-25, 26-35, 36-37 and at delivery. Data were analyzed to determine: (a) the within and between subject variability of aCL during pregnancy; (2) the temporal trend of aCL; and (3) the relation of serial measures of aCL with maternal complications of pregnancy.
We divided our cohort of 354 subjects into two groups. Group A included those subjects with consistently normal levels of aCL and group B those subjects with at least one elevated level of aCL. In group A the within subject variability was relatively low (28-34%). In group B we found wide fluctuations in aCL levels and a within subject variability of 88-91 %. Subjects in group B had no increase in maternal complications of pregnancy.
The present data suggest that aCL may fluctuate significantly during normal pregnancy and there is little clinical value in measuring aCL on a serial basis during pregnancy.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Antibodies, Anticardiolipin - blood</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoglobulin A - blood</subject><subject>Immunoglobulin G - blood</subject><subject>Immunoglobulin M - blood</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Labor, Obstetric</subject><subject>Longitudinal Studies</subject><subject>Pregnancy - blood</subject><subject>Pregnancy - immunology</subject><subject>Pregnancy Complications - blood</subject><subject>Pregnancy Complications - immunology</subject><subject>Pregnancy Trimester, First</subject><subject>Pregnancy Trimester, Second</subject><subject>Pregnancy Trimester, Third</subject><subject>Prospective Studies</subject><subject>Reference Values</subject><issn>0961-2033</issn><issn>1477-0962</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtLxDAUhYMo4zj6BwShK13VyaNNpu5k8AUDbnRd0uS2ZGiTmrTC_HtTZ3AjzOpyOd853AdC1wTfEyLEEhecUMxYkWOcYZxjfoLmJBMijQo9RfMJSCfiHF2EsMUYM1LwGZqtcs4Ew3OkNs42Zhi1sbJNOpBh9NCBHRJXJ9IORkmvjWtNb-xvXzltICR69MY2iXW-i77eQ2OlVbuHRMbGhR7UYL4hCTF5d4nOatkGuDrUBfp8fvpYv6ab95e39eMmVUzgIc0FhRWuCRfACZFM0VWutFYVpzUlmFQky4pcsIKojOmMSaB1NHKqMh43U2yBbve5cYKvEcJQdiYoaFtpwY2hFELkpCCrCN4dB6dAWogiknRPqrhU8FCXvTed9LuS4HL6Qfn_B9F0c4gfqw70n-Vw9Kgv93qQDZRbN_p4-3As8QdXjI8v</recordid><startdate>19951001</startdate><enddate>19951001</enddate><creator>Lynch, AM</creator><creator>Rutledge, JH</creator><creator>Stephens, JK</creator><creator>Murphy, JR</creator><creator>Marlar, RA</creator><creator>Davila, GH</creator><creator>Santos, ME</creator><creator>Emlen, W.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19951001</creationdate><title>Longitudinal measurement of anticardiolipin antibodies during normal pregnancy: a prospective study</title><author>Lynch, AM ; Rutledge, JH ; Stephens, JK ; Murphy, JR ; Marlar, RA ; Davila, GH ; Santos, ME ; Emlen, W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-572e80f167e611a3c285cddcb62f2101b144957391c43d43ae2f37062c46000c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Antibodies, Anticardiolipin - blood</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoglobulin A - blood</topic><topic>Immunoglobulin G - blood</topic><topic>Immunoglobulin M - blood</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Labor, Obstetric</topic><topic>Longitudinal Studies</topic><topic>Pregnancy - blood</topic><topic>Pregnancy - immunology</topic><topic>Pregnancy Complications - blood</topic><topic>Pregnancy Complications - immunology</topic><topic>Pregnancy Trimester, First</topic><topic>Pregnancy Trimester, Second</topic><topic>Pregnancy Trimester, Third</topic><topic>Prospective Studies</topic><topic>Reference Values</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lynch, AM</creatorcontrib><creatorcontrib>Rutledge, JH</creatorcontrib><creatorcontrib>Stephens, JK</creatorcontrib><creatorcontrib>Murphy, JR</creatorcontrib><creatorcontrib>Marlar, RA</creatorcontrib><creatorcontrib>Davila, GH</creatorcontrib><creatorcontrib>Santos, ME</creatorcontrib><creatorcontrib>Emlen, W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Lupus</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lynch, AM</au><au>Rutledge, JH</au><au>Stephens, JK</au><au>Murphy, JR</au><au>Marlar, RA</au><au>Davila, GH</au><au>Santos, ME</au><au>Emlen, W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Longitudinal measurement of anticardiolipin antibodies during normal pregnancy: a prospective study</atitle><jtitle>Lupus</jtitle><addtitle>Lupus</addtitle><date>1995-10-01</date><risdate>1995</risdate><volume>4</volume><issue>5</issue><spage>365</spage><epage>369</epage><pages>365-369</pages><issn>0961-2033</issn><eissn>1477-0962</eissn><abstract>We have previously shown that elevation of anticardiolipin antibodies (aCL) at the first prenatal visit is associated with increased fetal loss in normal pregnancy. The variation in aCL levels during normal pregnancy has not been established. To examine this question we measured IgG, IgM and IgA aCL levels five times during pregnancy at weeks 5-15, 16-25, 26-35, 36-37 and at delivery. Data were analyzed to determine: (a) the within and between subject variability of aCL during pregnancy; (2) the temporal trend of aCL; and (3) the relation of serial measures of aCL with maternal complications of pregnancy.
We divided our cohort of 354 subjects into two groups. Group A included those subjects with consistently normal levels of aCL and group B those subjects with at least one elevated level of aCL. In group A the within subject variability was relatively low (28-34%). In group B we found wide fluctuations in aCL levels and a within subject variability of 88-91 %. Subjects in group B had no increase in maternal complications of pregnancy.
The present data suggest that aCL may fluctuate significantly during normal pregnancy and there is little clinical value in measuring aCL on a serial basis during pregnancy.</abstract><cop>Thousand Oaks, CA</cop><pub>SAGE Publications</pub><pmid>8563730</pmid><doi>10.1177/096120339500400506</doi><tpages>5</tpages></addata></record> |
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| language | eng |
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| subjects | Adolescent Adult Antibodies, Anticardiolipin - blood Female Humans Immunoglobulin A - blood Immunoglobulin G - blood Immunoglobulin M - blood Infant, Newborn Infant, Premature Labor, Obstetric Longitudinal Studies Pregnancy - blood Pregnancy - immunology Pregnancy Complications - blood Pregnancy Complications - immunology Pregnancy Trimester, First Pregnancy Trimester, Second Pregnancy Trimester, Third Prospective Studies Reference Values |
| title | Longitudinal measurement of anticardiolipin antibodies during normal pregnancy: a prospective study |
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