Experimental encephalomyelitis modulates inositol and taurine in the spinal cord of biozzi mice
In this high resolution magnetic resonance spectroscopic study of experimental allergic encephalomyelitis (EAE) and Semliki Forest virus (SFV) infection of the Bioui AB/H mouse, marked increases in the initially low levels of N‐trimethyl compounds in the spinal cord were observed during probable dem...
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| Veröffentlicht in: | Magnetic resonance in medicine 1994-12, Vol.32 (6), p.692-697 |
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| container_title | Magnetic resonance in medicine |
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| creator | Preece, Nicholas E. Amor, Sandra Baker, David Gadian, David G. O'Neill, Janet K. Urenjak, Jutta |
| description | In this high resolution magnetic resonance spectroscopic study of experimental allergic encephalomyelitis (EAE) and Semliki Forest virus (SFV) infection of the Bioui AB/H mouse, marked increases in the initially low levels of N‐trimethyl compounds in the spinal cord were observed during probable demyelinating episodes. There was also a pronounced and reproducible modulation of the levels of taurine and myo‐inositol during acute and again during chronic relapsing EAE. The ratio of N‐acetyl‐aspartate to creatine in the spinal cord of mice infected with the mutant M9 strain of SFV decreased to approximately 70% of that seen in normal mice. |
| doi_str_mv | 10.1002/mrm.1910320603 |
| format | Article |
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There was also a pronounced and reproducible modulation of the levels of taurine and myo‐inositol during acute and again during chronic relapsing EAE. 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Reson. Med</addtitle><description>In this high resolution magnetic resonance spectroscopic study of experimental allergic encephalomyelitis (EAE) and Semliki Forest virus (SFV) infection of the Bioui AB/H mouse, marked increases in the initially low levels of N‐trimethyl compounds in the spinal cord were observed during probable demyelinating episodes. There was also a pronounced and reproducible modulation of the levels of taurine and myo‐inositol during acute and again during chronic relapsing EAE. The ratio of N‐acetyl‐aspartate to creatine in the spinal cord of mice infected with the mutant M9 strain of SFV decreased to approximately 70% of that seen in normal mice.</description><subject>Alphavirus Infections - metabolism</subject><subject>Animals</subject><subject>Aspartic Acid - analogs & derivatives</subject><subject>Aspartic Acid - metabolism</subject><subject>Biological and medical sciences</subject><subject>Biozzi</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Creatine - metabolism</subject><subject>EAE</subject><subject>Encephalitis, Viral - metabolism</subject><subject>Encephalitis, Viral - virology</subject><subject>Encephalomyelitis, Autoimmune, Experimental - metabolism</subject><subject>Human viral diseases</subject><subject>Infectious diseases</subject><subject>inositol</subject><subject>Inositol - metabolism</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Semliki forest virus</subject><subject>Spinal Cord - metabolism</subject><subject>taurine</subject><subject>Taurine - metabolism</subject><subject>Viral diseases</subject><subject>Viral diseases of the nervous system</subject><issn>0740-3194</issn><issn>1522-2594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEFv1DAQhS0EKkvplRuSD4hbFjt24viIVm1B2tKqArU3a-JMVIMTBzsR3f56jHa1iBOnkWa-92bmEfKGszVnrPwwxGHNNWeiZDUTz8iKV2VZlJWWz8mKKckKwbV8SV6l9J0xprWSJ-RENbVuNFsRc_44YXQDjjN4iqPF6QF8GHbo3ewSHUK3eJgxUTeG5ObgKYwdnWGJbsTcpPMD0jS5McttiB0NPW1deHpydHAWX5MXPfiEZ4d6Sr5dnH_dfCq215efNx-3hZVMiQJFq-qqbji3UoGqoOt0DZ3UDVQNaCFarHQnhWayZa1qtGi73OpZIxvo0YpT8n7vO8Xwc8E0m8Eli97DiGFJRimVzVSVwfUetDGkFLE3U34f4s5wZv4kanKi5m-iWfD24Ly0A3ZH_BBhnr87zCFZ8H2E0bp0xISo67LUGdN77JfzuPvPUnN1e_XPCcVe69KMj0ctxB-mVkJV5u7LpeGbm9t7tZXmXvwGBRufqg</recordid><startdate>199412</startdate><enddate>199412</enddate><creator>Preece, Nicholas E.</creator><creator>Amor, Sandra</creator><creator>Baker, David</creator><creator>Gadian, David G.</creator><creator>O'Neill, Janet K.</creator><creator>Urenjak, Jutta</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Williams & Wilkins</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199412</creationdate><title>Experimental encephalomyelitis modulates inositol and taurine in the spinal cord of biozzi mice</title><author>Preece, Nicholas E. ; Amor, Sandra ; Baker, David ; Gadian, David G. ; O'Neill, Janet K. ; Urenjak, Jutta</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4073-e3b7656811c47a75add96ad498a58a933be59d43904b0b7893bdbe5f0848afec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Alphavirus Infections - metabolism</topic><topic>Animals</topic><topic>Aspartic Acid - analogs & derivatives</topic><topic>Aspartic Acid - metabolism</topic><topic>Biological and medical sciences</topic><topic>Biozzi</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Creatine - metabolism</topic><topic>EAE</topic><topic>Encephalitis, Viral - metabolism</topic><topic>Encephalitis, Viral - virology</topic><topic>Encephalomyelitis, Autoimmune, Experimental - metabolism</topic><topic>Human viral diseases</topic><topic>Infectious diseases</topic><topic>inositol</topic><topic>Inositol - metabolism</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Semliki forest virus</topic><topic>Spinal Cord - metabolism</topic><topic>taurine</topic><topic>Taurine - metabolism</topic><topic>Viral diseases</topic><topic>Viral diseases of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Preece, Nicholas E.</creatorcontrib><creatorcontrib>Amor, Sandra</creatorcontrib><creatorcontrib>Baker, David</creatorcontrib><creatorcontrib>Gadian, David G.</creatorcontrib><creatorcontrib>O'Neill, Janet K.</creatorcontrib><creatorcontrib>Urenjak, Jutta</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Magnetic resonance in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Preece, Nicholas E.</au><au>Amor, Sandra</au><au>Baker, David</au><au>Gadian, David G.</au><au>O'Neill, Janet K.</au><au>Urenjak, Jutta</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experimental encephalomyelitis modulates inositol and taurine in the spinal cord of biozzi mice</atitle><jtitle>Magnetic resonance in medicine</jtitle><addtitle>Magn. Reson. Med</addtitle><date>1994-12</date><risdate>1994</risdate><volume>32</volume><issue>6</issue><spage>692</spage><epage>697</epage><pages>692-697</pages><issn>0740-3194</issn><eissn>1522-2594</eissn><coden>MRMEEN</coden><abstract>In this high resolution magnetic resonance spectroscopic study of experimental allergic encephalomyelitis (EAE) and Semliki Forest virus (SFV) infection of the Bioui AB/H mouse, marked increases in the initially low levels of N‐trimethyl compounds in the spinal cord were observed during probable demyelinating episodes. There was also a pronounced and reproducible modulation of the levels of taurine and myo‐inositol during acute and again during chronic relapsing EAE. The ratio of N‐acetyl‐aspartate to creatine in the spinal cord of mice infected with the mutant M9 strain of SFV decreased to approximately 70% of that seen in normal mice.</abstract><cop>Baltimore</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>7869890</pmid><doi>10.1002/mrm.1910320603</doi><tpages>6</tpages></addata></record> |
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| ispartof | Magnetic resonance in medicine, 1994-12, Vol.32 (6), p.692-697 |
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| language | eng |
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| subjects | Alphavirus Infections - metabolism Animals Aspartic Acid - analogs & derivatives Aspartic Acid - metabolism Biological and medical sciences Biozzi Chromatography, High Pressure Liquid Creatine - metabolism EAE Encephalitis, Viral - metabolism Encephalitis, Viral - virology Encephalomyelitis, Autoimmune, Experimental - metabolism Human viral diseases Infectious diseases inositol Inositol - metabolism Magnetic Resonance Spectroscopy Medical sciences Mice Mice, Inbred Strains Semliki forest virus Spinal Cord - metabolism taurine Taurine - metabolism Viral diseases Viral diseases of the nervous system |
| title | Experimental encephalomyelitis modulates inositol and taurine in the spinal cord of biozzi mice |
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