New regimen for interpleural block in children
Summary A new regimen for postoperative analgesia after thoracic surgery is proposed. Eight children received an interpleural infusion using bupivacaine 0.1% in a regimen from 0.5 ml·kg−1·h−1 up to 1 ml·kg−1·h−1, for 48 h according to the pain scores. The plasma levels after 24 h and 48 h were measu...
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| Veröffentlicht in: | Pediatric anesthesia 1995-01, Vol.5 (2), p.125-128 |
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| container_title | Pediatric anesthesia |
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| creator | GIAUFRÉ, ELISABETH BRUGUEROLLE, BERNARD RASTELLO, CÉLINE COQUET, MICHEL LOREC, ANNE MARIE |
| description | Summary
A new regimen for postoperative analgesia after thoracic surgery is proposed. Eight children received an interpleural infusion using bupivacaine 0.1% in a regimen from 0.5 ml·kg−1·h−1 up to 1 ml·kg−1·h−1, for 48 h according to the pain scores. The plasma levels after 24 h and 48 h were measured as well as the pleural level and in two patients the free fraction of plasma bupivacaine and the plasma PPX (a metabolite of bupivacaine) and one patient the orosomucoid (main plasma protein involved in bupivacaine protein binding) were also measured pre and postoperatively. The results shows the safety of such a regimen, for two days of postoperative analgesia. |
| doi_str_mv | 10.1111/j.1460-9592.1995.tb00259.x |
| format | Article |
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A new regimen for postoperative analgesia after thoracic surgery is proposed. Eight children received an interpleural infusion using bupivacaine 0.1% in a regimen from 0.5 ml·kg−1·h−1 up to 1 ml·kg−1·h−1, for 48 h according to the pain scores. The plasma levels after 24 h and 48 h were measured as well as the pleural level and in two patients the free fraction of plasma bupivacaine and the plasma PPX (a metabolite of bupivacaine) and one patient the orosomucoid (main plasma protein involved in bupivacaine protein binding) were also measured pre and postoperatively. The results shows the safety of such a regimen, for two days of postoperative analgesia.</description><identifier>ISSN: 1155-5645</identifier><identifier>EISSN: 1460-9592</identifier><identifier>DOI: 10.1111/j.1460-9592.1995.tb00259.x</identifier><identifier>PMID: 7489422</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>anaesthesia: technique ; Analgesia ; Anesthesia, Epidural ; Anesthetics, Local - administration & dosage ; Anesthetics, Local - analysis ; Anesthetics, Local - blood ; Bupivacaine - administration & dosage ; Bupivacaine - analogs & derivatives ; Bupivacaine - analysis ; Bupivacaine - blood ; Child ; Child, Preschool ; Humans ; Infant ; interpleural block ; Nerve Block ; Orosomucoid - analysis ; Pain Measurement ; Pain, Postoperative - prevention & control ; Pleura ; Pleural Effusion - chemistry ; Pneumonectomy ; Safety</subject><ispartof>Pediatric anesthesia, 1995-01, Vol.5 (2), p.125-128</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4075-241cc2286900754717f37fe9e250034b6a0933f501be43ec271e3259cde0015f3</citedby><cites>FETCH-LOGICAL-c4075-241cc2286900754717f37fe9e250034b6a0933f501be43ec271e3259cde0015f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1460-9592.1995.tb00259.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1460-9592.1995.tb00259.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7489422$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GIAUFRÉ, ELISABETH</creatorcontrib><creatorcontrib>BRUGUEROLLE, BERNARD</creatorcontrib><creatorcontrib>RASTELLO, CÉLINE</creatorcontrib><creatorcontrib>COQUET, MICHEL</creatorcontrib><creatorcontrib>LOREC, ANNE MARIE</creatorcontrib><title>New regimen for interpleural block in children</title><title>Pediatric anesthesia</title><addtitle>Paediatr Anaesth</addtitle><description>Summary
A new regimen for postoperative analgesia after thoracic surgery is proposed. Eight children received an interpleural infusion using bupivacaine 0.1% in a regimen from 0.5 ml·kg−1·h−1 up to 1 ml·kg−1·h−1, for 48 h according to the pain scores. The plasma levels after 24 h and 48 h were measured as well as the pleural level and in two patients the free fraction of plasma bupivacaine and the plasma PPX (a metabolite of bupivacaine) and one patient the orosomucoid (main plasma protein involved in bupivacaine protein binding) were also measured pre and postoperatively. The results shows the safety of such a regimen, for two days of postoperative analgesia.</description><subject>anaesthesia: technique</subject><subject>Analgesia</subject><subject>Anesthesia, Epidural</subject><subject>Anesthetics, Local - administration & dosage</subject><subject>Anesthetics, Local - analysis</subject><subject>Anesthetics, Local - blood</subject><subject>Bupivacaine - administration & dosage</subject><subject>Bupivacaine - analogs & derivatives</subject><subject>Bupivacaine - analysis</subject><subject>Bupivacaine - blood</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Humans</subject><subject>Infant</subject><subject>interpleural block</subject><subject>Nerve Block</subject><subject>Orosomucoid - analysis</subject><subject>Pain Measurement</subject><subject>Pain, Postoperative - prevention & control</subject><subject>Pleura</subject><subject>Pleural Effusion - chemistry</subject><subject>Pneumonectomy</subject><subject>Safety</subject><issn>1155-5645</issn><issn>1460-9592</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkE1PAjEQhhujQUR_gsnGg7dd-7mlHkwIKpiQVRONx2a3zOrCfmALAf693bDh7lw603fmbedB6IbgiPi4W0SExzhUQtGIKCWidYYxFSranaD-UTr1OREiFDEX5-jCuQXGhNGY9lBP8qHilPZRlMA2sPBdVFAHeWODol6DXZWwsWkZZGVjlv4qMD9FObdQX6KzPC0dXHXnAH0-P32Mp-HsdfIyHs1Cw7EUIeXEGEqHscK-5JLInMkcFFCBMeNZnGLFWC4wyYAzMFQSYH4BMwf_R5GzAbo9-K5s87sBt9ZV4QyUZVpDs3FaSr8Bl9Q33h8ajW2cs5DrlS2q1O41wbqFpRe6JaJbIrqFpTtYeueHr7tXNlkF8-NoR8frDwd9W5Sw_4ezfhslhApvEB4MCreG3dEgtUsdSyaF_komWig8e5yyd52wPzpohmM</recordid><startdate>19950101</startdate><enddate>19950101</enddate><creator>GIAUFRÉ, ELISABETH</creator><creator>BRUGUEROLLE, BERNARD</creator><creator>RASTELLO, CÉLINE</creator><creator>COQUET, MICHEL</creator><creator>LOREC, ANNE MARIE</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19950101</creationdate><title>New regimen for interpleural block in children</title><author>GIAUFRÉ, ELISABETH ; BRUGUEROLLE, BERNARD ; RASTELLO, CÉLINE ; COQUET, MICHEL ; LOREC, ANNE MARIE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4075-241cc2286900754717f37fe9e250034b6a0933f501be43ec271e3259cde0015f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>anaesthesia: technique</topic><topic>Analgesia</topic><topic>Anesthesia, Epidural</topic><topic>Anesthetics, Local - administration & dosage</topic><topic>Anesthetics, Local - analysis</topic><topic>Anesthetics, Local - blood</topic><topic>Bupivacaine - administration & dosage</topic><topic>Bupivacaine - analogs & derivatives</topic><topic>Bupivacaine - analysis</topic><topic>Bupivacaine - blood</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Humans</topic><topic>Infant</topic><topic>interpleural block</topic><topic>Nerve Block</topic><topic>Orosomucoid - analysis</topic><topic>Pain Measurement</topic><topic>Pain, Postoperative - prevention & control</topic><topic>Pleura</topic><topic>Pleural Effusion - chemistry</topic><topic>Pneumonectomy</topic><topic>Safety</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GIAUFRÉ, ELISABETH</creatorcontrib><creatorcontrib>BRUGUEROLLE, BERNARD</creatorcontrib><creatorcontrib>RASTELLO, CÉLINE</creatorcontrib><creatorcontrib>COQUET, MICHEL</creatorcontrib><creatorcontrib>LOREC, ANNE MARIE</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric anesthesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GIAUFRÉ, ELISABETH</au><au>BRUGUEROLLE, BERNARD</au><au>RASTELLO, CÉLINE</au><au>COQUET, MICHEL</au><au>LOREC, ANNE MARIE</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New regimen for interpleural block in children</atitle><jtitle>Pediatric anesthesia</jtitle><addtitle>Paediatr Anaesth</addtitle><date>1995-01-01</date><risdate>1995</risdate><volume>5</volume><issue>2</issue><spage>125</spage><epage>128</epage><pages>125-128</pages><issn>1155-5645</issn><eissn>1460-9592</eissn><abstract>Summary
A new regimen for postoperative analgesia after thoracic surgery is proposed. Eight children received an interpleural infusion using bupivacaine 0.1% in a regimen from 0.5 ml·kg−1·h−1 up to 1 ml·kg−1·h−1, for 48 h according to the pain scores. The plasma levels after 24 h and 48 h were measured as well as the pleural level and in two patients the free fraction of plasma bupivacaine and the plasma PPX (a metabolite of bupivacaine) and one patient the orosomucoid (main plasma protein involved in bupivacaine protein binding) were also measured pre and postoperatively. The results shows the safety of such a regimen, for two days of postoperative analgesia.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>7489422</pmid><doi>10.1111/j.1460-9592.1995.tb00259.x</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1155-5645 |
| ispartof | Pediatric anesthesia, 1995-01, Vol.5 (2), p.125-128 |
| issn | 1155-5645 1460-9592 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | anaesthesia: technique Analgesia Anesthesia, Epidural Anesthetics, Local - administration & dosage Anesthetics, Local - analysis Anesthetics, Local - blood Bupivacaine - administration & dosage Bupivacaine - analogs & derivatives Bupivacaine - analysis Bupivacaine - blood Child Child, Preschool Humans Infant interpleural block Nerve Block Orosomucoid - analysis Pain Measurement Pain, Postoperative - prevention & control Pleura Pleural Effusion - chemistry Pneumonectomy Safety |
| title | New regimen for interpleural block in children |
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