PBDX is the XG blood group gene
We have identified the Xg a antigen, encoded by the XG blood group gene, by employing rabbit polyclonal and mouse monoclonal antibodies raised against a peptide derived from the N-terminal domain of a candidate gene, referred to earlier as PBDX . In indirect haemagglutination assays, these anti-pept...
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| Veröffentlicht in: | Nature genetics 1994-11, Vol.8 (3), p.285-290 |
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| container_title | Nature genetics |
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| creator | Ellis, Nathan A Tippett, Patricia Petty, Alison Reid, Marion Weller, Polly A Ye, Tian Z German, James Goodfellow, Peter N Thomas, Stephen Banting, George |
| description | We have identified the Xg
a
antigen, encoded by the XG blood group gene, by employing rabbit polyclonal and mouse monoclonal antibodies raised against a peptide derived from the N-terminal domain of a candidate gene, referred to earlier as
PBDX
. In indirect haemagglutination assays, these anti-peptide antibodies react with Xg(a+) but not Xg(a−) erythrocytes. In antibody-specific immobilization of antigen (ASIA) and immunoblot assays, the anti-peptide antibodies react with the same molecule as does human anti-Xg
a
. Therefore, by its identity with PBDX, Xg
a
is identified as a cell-surface protein that is 48% homologous to CD99 (previously designated the 12E7 antigen), the product of
MIC2
which is tightly linked to
XG
.
PBDX
is renamed here
XG
. |
| doi_str_mv | 10.1038/ng1194-285 |
| format | Article |
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a
antigen, encoded by the XG blood group gene, by employing rabbit polyclonal and mouse monoclonal antibodies raised against a peptide derived from the N-terminal domain of a candidate gene, referred to earlier as
PBDX
. In indirect haemagglutination assays, these anti-peptide antibodies react with Xg(a+) but not Xg(a−) erythrocytes. In antibody-specific immobilization of antigen (ASIA) and immunoblot assays, the anti-peptide antibodies react with the same molecule as does human anti-Xg
a
. Therefore, by its identity with PBDX, Xg
a
is identified as a cell-surface protein that is 48% homologous to CD99 (previously designated the 12E7 antigen), the product of
MIC2
which is tightly linked to
XG
.
PBDX
is renamed here
XG
.</description><identifier>ISSN: 1061-4036</identifier><identifier>EISSN: 1546-1718</identifier><identifier>DOI: 10.1038/ng1194-285</identifier><identifier>PMID: 7533029</identifier><identifier>CODEN: NGENEC</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>12E7 Antigen ; Agriculture ; Amino Acid Sequence ; Animal Genetics and Genomics ; Animals ; Antibodies, Monoclonal - immunology ; Antigens, CD ; Base Sequence ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Blood Group Antigens - genetics ; blood group XG ; Blotting, Western ; Cancer Research ; Cell Adhesion Molecules - genetics ; Cell Adhesion Molecules - immunology ; Cell Adhesion Molecules - physiology ; Classical genetics, quantitative genetics, hybrids ; Cross Reactions ; Epitopes - immunology ; Fibroblasts - metabolism ; Fundamental and applied biological sciences. Psychology ; Gene Function ; Genes ; Genetic Linkage ; Genetics of eukaryotes. Biological and molecular evolution ; Hemagglutination Tests ; Hematopoietic Stem Cells - metabolism ; Human ; Human Genetics ; Humans ; man ; Membrane Glycoproteins - genetics ; Membrane Glycoproteins - immunology ; Mice ; Molecular Sequence Data ; Organ Specificity ; PBDX gene ; Polymerase Chain Reaction ; Rabbits ; RNA, Messenger - biosynthesis ; Sequence Homology, Amino Acid ; Tumor Cells, Cultured ; XG gene ; Xg super(a) antigen</subject><ispartof>Nature genetics, 1994-11, Vol.8 (3), p.285-290</ispartof><rights>Springer Nature America, Inc. 1994</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-51448c3d6cf491af9bbf2a8a43ee98f9cf9d566fe784cfe9f8e79a5fc9ff2c753</citedby><cites>FETCH-LOGICAL-c403t-51448c3d6cf491af9bbf2a8a43ee98f9cf9d566fe784cfe9f8e79a5fc9ff2c753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/ng1194-285$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/ng1194-285$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,2727,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3298465$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7533029$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ellis, Nathan A</creatorcontrib><creatorcontrib>Tippett, Patricia</creatorcontrib><creatorcontrib>Petty, Alison</creatorcontrib><creatorcontrib>Reid, Marion</creatorcontrib><creatorcontrib>Weller, Polly A</creatorcontrib><creatorcontrib>Ye, Tian Z</creatorcontrib><creatorcontrib>German, James</creatorcontrib><creatorcontrib>Goodfellow, Peter N</creatorcontrib><creatorcontrib>Thomas, Stephen</creatorcontrib><creatorcontrib>Banting, George</creatorcontrib><title>PBDX is the XG blood group gene</title><title>Nature genetics</title><addtitle>Nat Genet</addtitle><addtitle>Nat Genet</addtitle><description>We have identified the Xg
a
antigen, encoded by the XG blood group gene, by employing rabbit polyclonal and mouse monoclonal antibodies raised against a peptide derived from the N-terminal domain of a candidate gene, referred to earlier as
PBDX
. In indirect haemagglutination assays, these anti-peptide antibodies react with Xg(a+) but not Xg(a−) erythrocytes. In antibody-specific immobilization of antigen (ASIA) and immunoblot assays, the anti-peptide antibodies react with the same molecule as does human anti-Xg
a
. Therefore, by its identity with PBDX, Xg
a
is identified as a cell-surface protein that is 48% homologous to CD99 (previously designated the 12E7 antigen), the product of
MIC2
which is tightly linked to
XG
.
PBDX
is renamed here
XG
.</description><subject>12E7 Antigen</subject><subject>Agriculture</subject><subject>Amino Acid Sequence</subject><subject>Animal Genetics and Genomics</subject><subject>Animals</subject><subject>Antibodies, Monoclonal - immunology</subject><subject>Antigens, CD</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood Group Antigens - genetics</subject><subject>blood group XG</subject><subject>Blotting, Western</subject><subject>Cancer Research</subject><subject>Cell Adhesion Molecules - genetics</subject><subject>Cell Adhesion Molecules - immunology</subject><subject>Cell Adhesion Molecules - physiology</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>Cross Reactions</subject><subject>Epitopes - immunology</subject><subject>Fibroblasts - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Function</subject><subject>Genes</subject><subject>Genetic Linkage</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Hemagglutination Tests</subject><subject>Hematopoietic Stem Cells - metabolism</subject><subject>Human</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>man</subject><subject>Membrane Glycoproteins - genetics</subject><subject>Membrane Glycoproteins - immunology</subject><subject>Mice</subject><subject>Molecular Sequence Data</subject><subject>Organ Specificity</subject><subject>PBDX gene</subject><subject>Polymerase Chain Reaction</subject><subject>Rabbits</subject><subject>RNA, Messenger - biosynthesis</subject><subject>Sequence Homology, Amino Acid</subject><subject>Tumor Cells, Cultured</subject><subject>XG gene</subject><subject>Xg super(a) antigen</subject><issn>1061-4036</issn><issn>1546-1718</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9LwzAYhoMoc04v3sUexINSTZrfR506hYEeFHYLaZrUja6dSXvwvzejZV4ET_ngfXi-8H4AnCJ4gyAWt3WJkCRpJugeGCNKWIo4EvtxhgylBGJ2CI5CWEGICIFiBEacYgwzOQbnb_cPi2QZkvbTJotZkldNUySlb7pNUtraHoMDp6tgT4Z3Aj6eHt-nz-n8dfYyvZunJurblEaxMLhgxhGJtJN57jItNMHWSuGkcbKgjDnLBTHOSicsl5o6I53LTPzNBFz23o1vvjobWrVeBmOrSte26YLinBNBKPkXRIwhyhmM4FUPGt-E4K1TG79ca_-tEFTb2lRfm4q1RfhssHb52hY7dOgp5hdDroPRlfO6Nsuww3AmBWFbzXWPhZjUpfVq1XS-jsX9vTTp6Vq3nbc72-858Q9X3IsT</recordid><startdate>19941101</startdate><enddate>19941101</enddate><creator>Ellis, Nathan A</creator><creator>Tippett, Patricia</creator><creator>Petty, Alison</creator><creator>Reid, Marion</creator><creator>Weller, Polly A</creator><creator>Ye, Tian Z</creator><creator>German, James</creator><creator>Goodfellow, Peter N</creator><creator>Thomas, Stephen</creator><creator>Banting, George</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T3</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19941101</creationdate><title>PBDX is the XG blood group gene</title><author>Ellis, Nathan A ; Tippett, Patricia ; Petty, Alison ; Reid, Marion ; Weller, Polly A ; Ye, Tian Z ; German, James ; Goodfellow, Peter N ; Thomas, Stephen ; Banting, George</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-51448c3d6cf491af9bbf2a8a43ee98f9cf9d566fe784cfe9f8e79a5fc9ff2c753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>12E7 Antigen</topic><topic>Agriculture</topic><topic>Amino Acid Sequence</topic><topic>Animal Genetics and Genomics</topic><topic>Animals</topic><topic>Antibodies, Monoclonal - immunology</topic><topic>Antigens, CD</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blood Group Antigens - genetics</topic><topic>blood group XG</topic><topic>Blotting, Western</topic><topic>Cancer Research</topic><topic>Cell Adhesion Molecules - genetics</topic><topic>Cell Adhesion Molecules - immunology</topic><topic>Cell Adhesion Molecules - physiology</topic><topic>Classical genetics, quantitative genetics, hybrids</topic><topic>Cross Reactions</topic><topic>Epitopes - immunology</topic><topic>Fibroblasts - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Function</topic><topic>Genes</topic><topic>Genetic Linkage</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Hemagglutination Tests</topic><topic>Hematopoietic Stem Cells - metabolism</topic><topic>Human</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>man</topic><topic>Membrane Glycoproteins - genetics</topic><topic>Membrane Glycoproteins - immunology</topic><topic>Mice</topic><topic>Molecular Sequence Data</topic><topic>Organ Specificity</topic><topic>PBDX gene</topic><topic>Polymerase Chain Reaction</topic><topic>Rabbits</topic><topic>RNA, Messenger - biosynthesis</topic><topic>Sequence Homology, Amino Acid</topic><topic>Tumor Cells, Cultured</topic><topic>XG gene</topic><topic>Xg super(a) antigen</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ellis, Nathan A</creatorcontrib><creatorcontrib>Tippett, Patricia</creatorcontrib><creatorcontrib>Petty, Alison</creatorcontrib><creatorcontrib>Reid, Marion</creatorcontrib><creatorcontrib>Weller, Polly A</creatorcontrib><creatorcontrib>Ye, Tian Z</creatorcontrib><creatorcontrib>German, James</creatorcontrib><creatorcontrib>Goodfellow, Peter N</creatorcontrib><creatorcontrib>Thomas, Stephen</creatorcontrib><creatorcontrib>Banting, George</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Human Genome Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nature genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ellis, Nathan A</au><au>Tippett, Patricia</au><au>Petty, Alison</au><au>Reid, Marion</au><au>Weller, Polly A</au><au>Ye, Tian Z</au><au>German, James</au><au>Goodfellow, Peter N</au><au>Thomas, Stephen</au><au>Banting, George</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PBDX is the XG blood group gene</atitle><jtitle>Nature genetics</jtitle><stitle>Nat Genet</stitle><addtitle>Nat Genet</addtitle><date>1994-11-01</date><risdate>1994</risdate><volume>8</volume><issue>3</issue><spage>285</spage><epage>290</epage><pages>285-290</pages><issn>1061-4036</issn><eissn>1546-1718</eissn><coden>NGENEC</coden><abstract>We have identified the Xg
a
antigen, encoded by the XG blood group gene, by employing rabbit polyclonal and mouse monoclonal antibodies raised against a peptide derived from the N-terminal domain of a candidate gene, referred to earlier as
PBDX
. In indirect haemagglutination assays, these anti-peptide antibodies react with Xg(a+) but not Xg(a−) erythrocytes. In antibody-specific immobilization of antigen (ASIA) and immunoblot assays, the anti-peptide antibodies react with the same molecule as does human anti-Xg
a
. Therefore, by its identity with PBDX, Xg
a
is identified as a cell-surface protein that is 48% homologous to CD99 (previously designated the 12E7 antigen), the product of
MIC2
which is tightly linked to
XG
.
PBDX
is renamed here
XG
.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>7533029</pmid><doi>10.1038/ng1194-285</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1061-4036 |
| ispartof | Nature genetics, 1994-11, Vol.8 (3), p.285-290 |
| issn | 1061-4036 1546-1718 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77748454 |
| source | MEDLINE; Nature; SpringerLink Journals - AutoHoldings |
| subjects | 12E7 Antigen Agriculture Amino Acid Sequence Animal Genetics and Genomics Animals Antibodies, Monoclonal - immunology Antigens, CD Base Sequence Biological and medical sciences Biomedical and Life Sciences Biomedicine Blood Group Antigens - genetics blood group XG Blotting, Western Cancer Research Cell Adhesion Molecules - genetics Cell Adhesion Molecules - immunology Cell Adhesion Molecules - physiology Classical genetics, quantitative genetics, hybrids Cross Reactions Epitopes - immunology Fibroblasts - metabolism Fundamental and applied biological sciences. Psychology Gene Function Genes Genetic Linkage Genetics of eukaryotes. Biological and molecular evolution Hemagglutination Tests Hematopoietic Stem Cells - metabolism Human Human Genetics Humans man Membrane Glycoproteins - genetics Membrane Glycoproteins - immunology Mice Molecular Sequence Data Organ Specificity PBDX gene Polymerase Chain Reaction Rabbits RNA, Messenger - biosynthesis Sequence Homology, Amino Acid Tumor Cells, Cultured XG gene Xg super(a) antigen |
| title | PBDX is the XG blood group gene |
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