Metabolic Imaging of Ovarian Tumors with Carbon-11-Methionine: A PET Study
This study examines the potential of 11C-methionine as a PET tracer in metabolic imaging of benign and malignant ovarian tumors. Four patients with one or two benign ovarian tumors (endometriomas or cystadenomas), two patients with a tumor of borderline malignancy and seven patients with ovarian can...
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| Veröffentlicht in: | The Journal of nuclear medicine (1978) 1995-12, Vol.36 (12), p.2196-2200 |
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| container_title | The Journal of nuclear medicine (1978) |
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| creator | Lapela, Maria Leskinen-Kallio, Sirkku Varpula, Matti Grenman, Seija Salmi, Tuula Alanen, Kalle Nagren, Kjell Lehikoinen, Pertti Ruotsalainen, Ulla Teras, Mika Joensuu, Heikki |
| description | This study examines the potential of 11C-methionine as a PET tracer in metabolic imaging of benign and malignant ovarian tumors.
Four patients with one or two benign ovarian tumors (endometriomas or cystadenomas), two patients with a tumor of borderline malignancy and seven patients with ovarian cancer were studied with 11C-methionine and PET before laparotomy. CT or MRI were performed as a reference. Tracer uptake was quantitated by calculating tracer standardized uptake values (SUVs) and the kinetic influx constants (Ki values).
Benign or borderline malignant tumors did not accumulate 11C-methionine, whereas all carcinomas had significant uptake. The mean SUV of the primary carcinomas was 7.0 (s.d., 2.2) and the mean Ki was 0.14 min-1 (s.d., 0.1 min-1), but the distribution of tracer uptake was highly heterogenous in four of six tumors.
Ovarian cancer can be imaged with 11C-methionine and PET. This method also may be of value in the differential diagnosis between benign and malignant ovarian neoplasms. Due to physiological accumulations and methodological limitations, the value of 11C-methionine PET in the staging of ovarian cancer appears to be limited. |
| format | Article |
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Four patients with one or two benign ovarian tumors (endometriomas or cystadenomas), two patients with a tumor of borderline malignancy and seven patients with ovarian cancer were studied with 11C-methionine and PET before laparotomy. CT or MRI were performed as a reference. Tracer uptake was quantitated by calculating tracer standardized uptake values (SUVs) and the kinetic influx constants (Ki values).
Benign or borderline malignant tumors did not accumulate 11C-methionine, whereas all carcinomas had significant uptake. The mean SUV of the primary carcinomas was 7.0 (s.d., 2.2) and the mean Ki was 0.14 min-1 (s.d., 0.1 min-1), but the distribution of tracer uptake was highly heterogenous in four of six tumors.
Ovarian cancer can be imaged with 11C-methionine and PET. This method also may be of value in the differential diagnosis between benign and malignant ovarian neoplasms. Due to physiological accumulations and methodological limitations, the value of 11C-methionine PET in the staging of ovarian cancer appears to be limited.</description><identifier>ISSN: 0161-5505</identifier><identifier>EISSN: 1535-5667</identifier><identifier>PMID: 8523104</identifier><language>eng</language><publisher>Reston, VA: Soc Nuclear Med</publisher><subject>Adenocarcinoma, Clear Cell - diagnosis ; Adenocarcinoma, Clear Cell - diagnostic imaging ; Biological and medical sciences ; Carbon Radioisotopes ; Carcinoma, Endometrioid - diagnosis ; Carcinoma, Endometrioid - diagnostic imaging ; Cystadenocarcinoma, Serous - diagnosis ; Cystadenocarcinoma, Serous - diagnostic imaging ; Cystadenoma - diagnosis ; Cystadenoma - diagnostic imaging ; Diagnosis, Differential ; Endocrine glands. Genital system. Mammary gland ; Endometriosis - diagnosis ; Endometriosis - diagnostic imaging ; Female ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Magnetic Resonance Imaging ; Medical sciences ; Methionine ; Middle Aged ; Ovarian Diseases - diagnosis ; Ovarian Diseases - diagnostic imaging ; Ovarian Neoplasms - diagnosis ; Ovarian Neoplasms - diagnostic imaging ; Radionuclide investigations ; Tomography, Emission-Computed ; Tomography, X-Ray Computed</subject><ispartof>The Journal of nuclear medicine (1978), 1995-12, Vol.36 (12), p.2196-2200</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2946137$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8523104$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lapela, Maria</creatorcontrib><creatorcontrib>Leskinen-Kallio, Sirkku</creatorcontrib><creatorcontrib>Varpula, Matti</creatorcontrib><creatorcontrib>Grenman, Seija</creatorcontrib><creatorcontrib>Salmi, Tuula</creatorcontrib><creatorcontrib>Alanen, Kalle</creatorcontrib><creatorcontrib>Nagren, Kjell</creatorcontrib><creatorcontrib>Lehikoinen, Pertti</creatorcontrib><creatorcontrib>Ruotsalainen, Ulla</creatorcontrib><creatorcontrib>Teras, Mika</creatorcontrib><creatorcontrib>Joensuu, Heikki</creatorcontrib><title>Metabolic Imaging of Ovarian Tumors with Carbon-11-Methionine: A PET Study</title><title>The Journal of nuclear medicine (1978)</title><addtitle>J Nucl Med</addtitle><description>This study examines the potential of 11C-methionine as a PET tracer in metabolic imaging of benign and malignant ovarian tumors.
Four patients with one or two benign ovarian tumors (endometriomas or cystadenomas), two patients with a tumor of borderline malignancy and seven patients with ovarian cancer were studied with 11C-methionine and PET before laparotomy. CT or MRI were performed as a reference. Tracer uptake was quantitated by calculating tracer standardized uptake values (SUVs) and the kinetic influx constants (Ki values).
Benign or borderline malignant tumors did not accumulate 11C-methionine, whereas all carcinomas had significant uptake. The mean SUV of the primary carcinomas was 7.0 (s.d., 2.2) and the mean Ki was 0.14 min-1 (s.d., 0.1 min-1), but the distribution of tracer uptake was highly heterogenous in four of six tumors.
Ovarian cancer can be imaged with 11C-methionine and PET. This method also may be of value in the differential diagnosis between benign and malignant ovarian neoplasms. Due to physiological accumulations and methodological limitations, the value of 11C-methionine PET in the staging of ovarian cancer appears to be limited.</description><subject>Adenocarcinoma, Clear Cell - diagnosis</subject><subject>Adenocarcinoma, Clear Cell - diagnostic imaging</subject><subject>Biological and medical sciences</subject><subject>Carbon Radioisotopes</subject><subject>Carcinoma, Endometrioid - diagnosis</subject><subject>Carcinoma, Endometrioid - diagnostic imaging</subject><subject>Cystadenocarcinoma, Serous - diagnosis</subject><subject>Cystadenocarcinoma, Serous - diagnostic imaging</subject><subject>Cystadenoma - diagnosis</subject><subject>Cystadenoma - diagnostic imaging</subject><subject>Diagnosis, Differential</subject><subject>Endocrine glands. Genital system. Mammary gland</subject><subject>Endometriosis - diagnosis</subject><subject>Endometriosis - diagnostic imaging</subject><subject>Female</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical sciences</subject><subject>Methionine</subject><subject>Middle Aged</subject><subject>Ovarian Diseases - diagnosis</subject><subject>Ovarian Diseases - diagnostic imaging</subject><subject>Ovarian Neoplasms - diagnosis</subject><subject>Ovarian Neoplasms - diagnostic imaging</subject><subject>Radionuclide investigations</subject><subject>Tomography, Emission-Computed</subject><subject>Tomography, X-Ray Computed</subject><issn>0161-5505</issn><issn>1535-5667</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9z11LwzAUBuAgypzTnyDkQsSbQtI0H_NujKmTyQTndTlN0zWjTWfSOvbv7Vjx6ly8z3k55wKNKWc84kLISzQmVNCIc8Kv0U0IO0KIUEqN0EjxmFGSjNH7h2khayqr8bKGrXVb3BR4_QvegsObrm58wAfblngOPmtcRGnUr5S2cdaZZzzDn4sN_mq7_HiLrgqogrkb5gR9vyw287dotX5dzmerqIyFaiNJNDfJVIEGncf9gdoYwpTKiWZGUS4LKWKdS1EkgsgpTQiYQmUSFGc5yxWboMdz7943P50JbVrboE1VgTNNF1IpZaJIcoL3A-yy2uTp3tsa_DEdnu_zhyGHoKEqPDhtwz-Lp4mgTPbs6cxKuy0P1pvUdboy4E-dO1czkdI4jelUsD8ekW9Q</recordid><startdate>19951201</startdate><enddate>19951201</enddate><creator>Lapela, Maria</creator><creator>Leskinen-Kallio, Sirkku</creator><creator>Varpula, Matti</creator><creator>Grenman, Seija</creator><creator>Salmi, Tuula</creator><creator>Alanen, Kalle</creator><creator>Nagren, Kjell</creator><creator>Lehikoinen, Pertti</creator><creator>Ruotsalainen, Ulla</creator><creator>Teras, Mika</creator><creator>Joensuu, Heikki</creator><general>Soc Nuclear Med</general><general>Society of Nuclear Medicine</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19951201</creationdate><title>Metabolic Imaging of Ovarian Tumors with Carbon-11-Methionine: A PET Study</title><author>Lapela, Maria ; Leskinen-Kallio, Sirkku ; Varpula, Matti ; Grenman, Seija ; Salmi, Tuula ; Alanen, Kalle ; Nagren, Kjell ; Lehikoinen, Pertti ; Ruotsalainen, Ulla ; Teras, Mika ; Joensuu, Heikki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h268t-70c5e498acacd2161cee0388d0c3e8157f762cd76f46079140aef8b7a853d3d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adenocarcinoma, Clear Cell - diagnosis</topic><topic>Adenocarcinoma, Clear Cell - diagnostic imaging</topic><topic>Biological and medical sciences</topic><topic>Carbon Radioisotopes</topic><topic>Carcinoma, Endometrioid - diagnosis</topic><topic>Carcinoma, Endometrioid - diagnostic imaging</topic><topic>Cystadenocarcinoma, Serous - diagnosis</topic><topic>Cystadenocarcinoma, Serous - diagnostic imaging</topic><topic>Cystadenoma - diagnosis</topic><topic>Cystadenoma - diagnostic imaging</topic><topic>Diagnosis, Differential</topic><topic>Endocrine glands. Genital system. Mammary gland</topic><topic>Endometriosis - diagnosis</topic><topic>Endometriosis - diagnostic imaging</topic><topic>Female</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Magnetic Resonance Imaging</topic><topic>Medical sciences</topic><topic>Methionine</topic><topic>Middle Aged</topic><topic>Ovarian Diseases - diagnosis</topic><topic>Ovarian Diseases - diagnostic imaging</topic><topic>Ovarian Neoplasms - diagnosis</topic><topic>Ovarian Neoplasms - diagnostic imaging</topic><topic>Radionuclide investigations</topic><topic>Tomography, Emission-Computed</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lapela, Maria</creatorcontrib><creatorcontrib>Leskinen-Kallio, Sirkku</creatorcontrib><creatorcontrib>Varpula, Matti</creatorcontrib><creatorcontrib>Grenman, Seija</creatorcontrib><creatorcontrib>Salmi, Tuula</creatorcontrib><creatorcontrib>Alanen, Kalle</creatorcontrib><creatorcontrib>Nagren, Kjell</creatorcontrib><creatorcontrib>Lehikoinen, Pertti</creatorcontrib><creatorcontrib>Ruotsalainen, Ulla</creatorcontrib><creatorcontrib>Teras, Mika</creatorcontrib><creatorcontrib>Joensuu, Heikki</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nuclear medicine (1978)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lapela, Maria</au><au>Leskinen-Kallio, Sirkku</au><au>Varpula, Matti</au><au>Grenman, Seija</au><au>Salmi, Tuula</au><au>Alanen, Kalle</au><au>Nagren, Kjell</au><au>Lehikoinen, Pertti</au><au>Ruotsalainen, Ulla</au><au>Teras, Mika</au><au>Joensuu, Heikki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolic Imaging of Ovarian Tumors with Carbon-11-Methionine: A PET Study</atitle><jtitle>The Journal of nuclear medicine (1978)</jtitle><addtitle>J Nucl Med</addtitle><date>1995-12-01</date><risdate>1995</risdate><volume>36</volume><issue>12</issue><spage>2196</spage><epage>2200</epage><pages>2196-2200</pages><issn>0161-5505</issn><eissn>1535-5667</eissn><abstract>This study examines the potential of 11C-methionine as a PET tracer in metabolic imaging of benign and malignant ovarian tumors.
Four patients with one or two benign ovarian tumors (endometriomas or cystadenomas), two patients with a tumor of borderline malignancy and seven patients with ovarian cancer were studied with 11C-methionine and PET before laparotomy. CT or MRI were performed as a reference. Tracer uptake was quantitated by calculating tracer standardized uptake values (SUVs) and the kinetic influx constants (Ki values).
Benign or borderline malignant tumors did not accumulate 11C-methionine, whereas all carcinomas had significant uptake. The mean SUV of the primary carcinomas was 7.0 (s.d., 2.2) and the mean Ki was 0.14 min-1 (s.d., 0.1 min-1), but the distribution of tracer uptake was highly heterogenous in four of six tumors.
Ovarian cancer can be imaged with 11C-methionine and PET. This method also may be of value in the differential diagnosis between benign and malignant ovarian neoplasms. Due to physiological accumulations and methodological limitations, the value of 11C-methionine PET in the staging of ovarian cancer appears to be limited.</abstract><cop>Reston, VA</cop><pub>Soc Nuclear Med</pub><pmid>8523104</pmid><tpages>5</tpages></addata></record> |
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| subjects | Adenocarcinoma, Clear Cell - diagnosis Adenocarcinoma, Clear Cell - diagnostic imaging Biological and medical sciences Carbon Radioisotopes Carcinoma, Endometrioid - diagnosis Carcinoma, Endometrioid - diagnostic imaging Cystadenocarcinoma, Serous - diagnosis Cystadenocarcinoma, Serous - diagnostic imaging Cystadenoma - diagnosis Cystadenoma - diagnostic imaging Diagnosis, Differential Endocrine glands. Genital system. Mammary gland Endometriosis - diagnosis Endometriosis - diagnostic imaging Female Humans Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Imaging Medical sciences Methionine Middle Aged Ovarian Diseases - diagnosis Ovarian Diseases - diagnostic imaging Ovarian Neoplasms - diagnosis Ovarian Neoplasms - diagnostic imaging Radionuclide investigations Tomography, Emission-Computed Tomography, X-Ray Computed |
| title | Metabolic Imaging of Ovarian Tumors with Carbon-11-Methionine: A PET Study |
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