Augmentation of Host Resistance against Bacterial Infection by Treatment with Leustroducsin B, a New CSF Inducer

We tested the in vivo activity of leustroducsin B (LSN B), a new colony-stimulating factor (CSF) inducer isolated from the culture broth of Streptomyces platensis, with mice infected with Escherichia coli. Treatment with LSN B augmented the host resistance to lethal infection of E. coli at doses bet...

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Veröffentlicht in:	MICROBIOLOGY and IMMUNOLOGY 1994, Vol.38(9), pp.741-745
Hauptverfasser:	Kohama, Takafumi, Katayama, Toshiaki, Inukai, Masatoshi, Maeda, Hiroaki, Shiraishi, Akio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - pharmacology Bacteriology Biological and medical sciences Colony-Stimulating Factors - pharmacology CSF inducer Enzyme-Linked Immunosorbent Assay Escherichia coli Escherichia coli Infections - blood Escherichia coli Infections - immunology Escherichia coli Infections - prevention & control Fundamental and applied biological sciences. Psychology Host resistance Immunity - drug effects Interleukin-6 Interleukin-6 - blood Lactones - pharmacology Leustroducsin Male Mice Mice, Inbred ICR Microbiology Neutrophils - drug effects Neutrophils - physiology Organophosphorus Compounds - pharmacology Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains Pyrones Streptomyces platensis Superoxides - metabolism
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