Blood oxygenation dependence of t1 and t2 in the isolated, perfused rabbit heart at 4.7t
An MR line scan protocol has been used to measure relaxation parameters (T1 and T2) in isolated, blood perfused rabbit hearts at various blood oxygenations. Hearts were retro‐gradely perfused at 37°C with a cardioplegic solution (modified St. Thomas' solution) containing sheep red blood cells a...
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| Veröffentlicht in: | Magnetic resonance in medicine 1995-10, Vol.34 (4), p.623-627 |
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| container_title | Magnetic resonance in medicine |
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| creator | Atalay, Michael K. Reeder, Scott B. Zerhouni, Elias A. Forder, John R. |
| description | An MR line scan protocol has been used to measure relaxation parameters (T1 and T2) in isolated, blood perfused rabbit hearts at various blood oxygenations. Hearts were retro‐gradely perfused at 37°C with a cardioplegic solution (modified St. Thomas' solution) containing sheep red blood cells and adenosine (1 mM) to maximally vasodilate the coronary vascular bed. Arresting the hearts eliminated motion complications and minimized arteriovenous oxygenation differences. The authors have found that under conditions of stable flow, there is a strong correlation between T2 in myocardial septa and hemoglobin (Hb) saturation, while tissue T1 is virtually independent of blood oxygenation. These effects are believed to be due to the paramagnetic agent deoxyhemoglobin. |
| doi_str_mv | 10.1002/mrm.1910340420 |
| format | Article |
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Hearts were retro‐gradely perfused at 37°C with a cardioplegic solution (modified St. Thomas' solution) containing sheep red blood cells and adenosine (1 mM) to maximally vasodilate the coronary vascular bed. Arresting the hearts eliminated motion complications and minimized arteriovenous oxygenation differences. The authors have found that under conditions of stable flow, there is a strong correlation between T2 in myocardial septa and hemoglobin (Hb) saturation, while tissue T1 is virtually independent of blood oxygenation. 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Reson. Med</addtitle><description>An MR line scan protocol has been used to measure relaxation parameters (T1 and T2) in isolated, blood perfused rabbit hearts at various blood oxygenations. Hearts were retro‐gradely perfused at 37°C with a cardioplegic solution (modified St. Thomas' solution) containing sheep red blood cells and adenosine (1 mM) to maximally vasodilate the coronary vascular bed. Arresting the hearts eliminated motion complications and minimized arteriovenous oxygenation differences. The authors have found that under conditions of stable flow, there is a strong correlation between T2 in myocardial septa and hemoglobin (Hb) saturation, while tissue T1 is virtually independent of blood oxygenation. These effects are believed to be due to the paramagnetic agent deoxyhemoglobin.</description><subject>Adenosine - therapeutic use</subject><subject>Animals</subject><subject>Bicarbonates - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Calcium Chloride - therapeutic use</subject><subject>Cardioplegic Solutions - therapeutic use</subject><subject>Cardiovascular system</subject><subject>Coronary Circulation</subject><subject>Coronary Vessels - anatomy & histology</subject><subject>Erythrocytes</subject><subject>functional MRI</subject><subject>Heart - anatomy & histology</subject><subject>Heart Arrest, Induced</subject><subject>Heart Septum - anatomy & histology</subject><subject>Heart Ventricles - anatomy & histology</subject><subject>Hemoglobins - metabolism</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Magnesium - therapeutic use</subject><subject>Magnetic Resonance Imaging</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>myocardial imaging</subject><subject>myocardial oxygen content</subject><subject>Myocardium - metabolism</subject><subject>Oxygen - blood</subject><subject>Potassium Chloride - therapeutic use</subject><subject>Rabbits</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Sheep</subject><subject>Sodium Chloride - therapeutic use</subject><subject>Tissue Distribution</subject><subject>Vasodilation</subject><issn>0740-3194</issn><issn>1522-2594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkc1vEzEQxS0EKqFw5YbkA-qpG8bfu0da0YBI-RKIiovlXY-pYT-C7Yjmv2dRovQ0Gr3fG43eI-Q5gyUD4K-GNCxZw0BIkBwekAVTnFdcNfIhWYCRUAnWyMfkSc6_AKBpjDwhJ7XiEgRfkJuLfpo8ne52P3F0JU4j9bjB0ePYIZ0CLYy60dPCaRxpuUUa89S7gv6cbjCFbUZPk2vbWOgtulSoK1QuTXlKHgXXZ3x2mKfk29Wbr5dvq_XH1bvL1-sqclFDFQA0cMC2YyZ4RKGl5rxz83Mavea10jzwthGeKVXXTd0F3WilgkbmutaLU3K2v7tJ058t5mKHmDvsezfitM3WGCO1NGYGXxzAbTugt5sUB5d29hDFrL886C53rg_JjV3MR0zo2tRSzlizx_7GHndHmYH9X4ed67D3ddjrL9f32-yt9t6YC94dvS79ttoIo-z3DyurPq8u1u9_fLI34h_tsotc</recordid><startdate>199510</startdate><enddate>199510</enddate><creator>Atalay, Michael K.</creator><creator>Reeder, Scott B.</creator><creator>Zerhouni, Elias A.</creator><creator>Forder, John R.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Williams & Wilkins</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199510</creationdate><title>Blood oxygenation dependence of t1 and t2 in the isolated, perfused rabbit heart at 4.7t</title><author>Atalay, Michael K. ; Reeder, Scott B. ; Zerhouni, Elias A. ; Forder, John R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i2380-f006020ebc17fdee364622ca0326ed628562f2b93d1558898cf69655f6e1acbd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adenosine - therapeutic use</topic><topic>Animals</topic><topic>Bicarbonates - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Calcium Chloride - therapeutic use</topic><topic>Cardioplegic Solutions - therapeutic use</topic><topic>Cardiovascular system</topic><topic>Coronary Circulation</topic><topic>Coronary Vessels - anatomy & histology</topic><topic>Erythrocytes</topic><topic>functional MRI</topic><topic>Heart - anatomy & histology</topic><topic>Heart Arrest, Induced</topic><topic>Heart Septum - anatomy & histology</topic><topic>Heart Ventricles - anatomy & histology</topic><topic>Hemoglobins - metabolism</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Magnesium - therapeutic use</topic><topic>Magnetic Resonance Imaging</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>myocardial imaging</topic><topic>myocardial oxygen content</topic><topic>Myocardium - metabolism</topic><topic>Oxygen - blood</topic><topic>Potassium Chloride - therapeutic use</topic><topic>Rabbits</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Sheep</topic><topic>Sodium Chloride - therapeutic use</topic><topic>Tissue Distribution</topic><topic>Vasodilation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Atalay, Michael K.</creatorcontrib><creatorcontrib>Reeder, Scott B.</creatorcontrib><creatorcontrib>Zerhouni, Elias A.</creatorcontrib><creatorcontrib>Forder, John R.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Magnetic resonance in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Atalay, Michael K.</au><au>Reeder, Scott B.</au><au>Zerhouni, Elias A.</au><au>Forder, John R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blood oxygenation dependence of t1 and t2 in the isolated, perfused rabbit heart at 4.7t</atitle><jtitle>Magnetic resonance in medicine</jtitle><addtitle>Magn. Reson. Med</addtitle><date>1995-10</date><risdate>1995</risdate><volume>34</volume><issue>4</issue><spage>623</spage><epage>627</epage><pages>623-627</pages><issn>0740-3194</issn><eissn>1522-2594</eissn><coden>MRMEEN</coden><abstract>An MR line scan protocol has been used to measure relaxation parameters (T1 and T2) in isolated, blood perfused rabbit hearts at various blood oxygenations. Hearts were retro‐gradely perfused at 37°C with a cardioplegic solution (modified St. Thomas' solution) containing sheep red blood cells and adenosine (1 mM) to maximally vasodilate the coronary vascular bed. Arresting the hearts eliminated motion complications and minimized arteriovenous oxygenation differences. The authors have found that under conditions of stable flow, there is a strong correlation between T2 in myocardial septa and hemoglobin (Hb) saturation, while tissue T1 is virtually independent of blood oxygenation. These effects are believed to be due to the paramagnetic agent deoxyhemoglobin.</abstract><cop>Baltimore</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>8524032</pmid><doi>10.1002/mrm.1910340420</doi><tpages>5</tpages></addata></record> |
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| subjects | Adenosine - therapeutic use Animals Bicarbonates - therapeutic use Biological and medical sciences Calcium Chloride - therapeutic use Cardioplegic Solutions - therapeutic use Cardiovascular system Coronary Circulation Coronary Vessels - anatomy & histology Erythrocytes functional MRI Heart - anatomy & histology Heart Arrest, Induced Heart Septum - anatomy & histology Heart Ventricles - anatomy & histology Hemoglobins - metabolism Investigative techniques, diagnostic techniques (general aspects) Magnesium - therapeutic use Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Male Medical sciences myocardial imaging myocardial oxygen content Myocardium - metabolism Oxygen - blood Potassium Chloride - therapeutic use Rabbits Radiodiagnosis. Nmr imagery. Nmr spectrometry Sheep Sodium Chloride - therapeutic use Tissue Distribution Vasodilation |
| title | Blood oxygenation dependence of t1 and t2 in the isolated, perfused rabbit heart at 4.7t |
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