The effect of different dose levels of degradable starch microspheres (Spherex®) on the distribution of a cytotoxic drug after regional administration to tumour-bearing rats

Tumour uptake of a radiolabelled anticancer drug, tauromustine ([ 14C]TCNU), was investigated, using two different routes of administration in rats with colon adenocarcinomas implanted in the liver. Intra-arterial administration produced higher concentrations of the drug and/or its metabolites in tu...

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