In vitro and in vivo evaluation in dogs and pigs of a hydrophilic matrix containing propylthiouracil

A hydrophilic matrix tablet containing 300 mg of propylthiouracil was formulated with several types of hydroxypropylmethylcellulose. The influence of polymer and drug granule particle size, polymer concentration, crystallinity and geometry of the polymer particles, the polymer incorporation outside...

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Veröffentlicht in:	Pharmaceutical research 1994-11, Vol.11 (11), p.1663-1668
Hauptverfasser:	KABANDA, L, LEFEBVRE, R. A, VAN BREE, H. J, REMON, J. P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biological Availability Delayed-Action Preparations Dogs Evaluation Studies as Topic Hardness Hormones. Endocrine system Hypromellose Derivatives Medical sciences Methylcellulose - analogs & derivatives Particle Size Pharmacology. Drug treatments Propylthiouracil - administration & dosage Propylthiouracil - pharmacokinetics Solubility Swine Tablets Water - chemistry
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