92-kDa gelatinase (matrix metalloproteinase-9) is induced in rat amnion immediately prior to parturition
The fetal membranes undergo striking changes in structure before delivery that involve catabolism of the extracellular matrix. To investigate the role of specific enzymes in this process, we examined gelatinase activities in rat amnion, visceral yolk sac placenta, and placenta and amniotic fluid bet...
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| Veröffentlicht in: | Biology of reproduction 1995-08, Vol.53 (2), p.339-344 |
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| creator | H Lei F Vadillo-Ortega L G Paavola J F Strauss, 3rd |
| description | The fetal membranes undergo striking changes in structure before delivery that involve catabolism of the extracellular matrix.
To investigate the role of specific enzymes in this process, we examined gelatinase activities in rat amnion, visceral yolk
sac placenta, and placenta and amniotic fluid between Days 18-21 of pregnancy. Matrix metalloproteinase (MMP)-2 was present
in amnion on all days, and its activity increased slightly on Day 21. The 92-kDa gelatinase, MMP-9, was not detected on Days
18-20 but appeared by the morning of Day 21. There was a marked increase in MMP-9 mRNA in the amnion on Day 20, preceding
the appearance of MMP-9 activity. Western blotting confirmed an increase in MMP-9 protein in amnion on Day 21. MMP-2 and MMP-9
activities were detected in extracts of whole yolk sac placenta, placenta, and amniotic fluid, but there were no striking
changes in these gelatinases between Days 18 and 21. However, the capsular regions of the visceral yolk sac placentae, which
thin and rupture during labor, did show higher MMP-9 activity on Day 21 than on Days 18 and 20. We suggest that the striking
increase in MMP-9 expression in amnion and possibly the capsular region of the visceral yolk sac placenta approximately 12
h prior to delivery is responsible, in part, for the alterations in the structure of these fetal membranes before parturition. |
| doi_str_mv | 10.1095/biolreprod53.2.339 |
| format | Article |
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To investigate the role of specific enzymes in this process, we examined gelatinase activities in rat amnion, visceral yolk
sac placenta, and placenta and amniotic fluid between Days 18-21 of pregnancy. Matrix metalloproteinase (MMP)-2 was present
in amnion on all days, and its activity increased slightly on Day 21. The 92-kDa gelatinase, MMP-9, was not detected on Days
18-20 but appeared by the morning of Day 21. There was a marked increase in MMP-9 mRNA in the amnion on Day 20, preceding
the appearance of MMP-9 activity. Western blotting confirmed an increase in MMP-9 protein in amnion on Day 21. MMP-2 and MMP-9
activities were detected in extracts of whole yolk sac placenta, placenta, and amniotic fluid, but there were no striking
changes in these gelatinases between Days 18 and 21. However, the capsular regions of the visceral yolk sac placentae, which
thin and rupture during labor, did show higher MMP-9 activity on Day 21 than on Days 18 and 20. We suggest that the striking
increase in MMP-9 expression in amnion and possibly the capsular region of the visceral yolk sac placenta approximately 12
h prior to delivery is responsible, in part, for the alterations in the structure of these fetal membranes before parturition.</description><identifier>ISSN: 0006-3363</identifier><identifier>EISSN: 1529-7268</identifier><identifier>DOI: 10.1095/biolreprod53.2.339</identifier><identifier>PMID: 7492685</identifier><identifier>CODEN: BIREBV</identifier><language>eng</language><publisher>Madison, WI: Society for the Study of Reproduction</publisher><subject>Amnion - enzymology ; Amniotic Fluid - enzymology ; Animals ; Base Sequence ; Biological and medical sciences ; Blotting, Western ; Collagenases - biosynthesis ; Collagenases - genetics ; Embryology: invertebrates and vertebrates. Teratology ; Extracellular Matrix - metabolism ; Female ; Fetal membranes ; Fundamental and applied biological sciences. Psychology ; General aspects. Development. Fetal membranes ; Labor, Obstetric - physiology ; Matrix Metalloproteinase 9 ; Molecular Sequence Data ; Molecular Weight ; Placenta - enzymology ; Pregnancy ; Rats ; Rats, Sprague-Dawley ; RNA, Messenger - analysis ; Time Factors ; Yolk Sac - enzymology</subject><ispartof>Biology of reproduction, 1995-08, Vol.53 (2), p.339-344</ispartof><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27928,27929</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3673340$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7492685$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>H Lei</creatorcontrib><creatorcontrib>F Vadillo-Ortega</creatorcontrib><creatorcontrib>L G Paavola</creatorcontrib><creatorcontrib>J F Strauss, 3rd</creatorcontrib><title>92-kDa gelatinase (matrix metalloproteinase-9) is induced in rat amnion immediately prior to parturition</title><title>Biology of reproduction</title><addtitle>Biol Reprod</addtitle><description>The fetal membranes undergo striking changes in structure before delivery that involve catabolism of the extracellular matrix.
To investigate the role of specific enzymes in this process, we examined gelatinase activities in rat amnion, visceral yolk
sac placenta, and placenta and amniotic fluid between Days 18-21 of pregnancy. Matrix metalloproteinase (MMP)-2 was present
in amnion on all days, and its activity increased slightly on Day 21. The 92-kDa gelatinase, MMP-9, was not detected on Days
18-20 but appeared by the morning of Day 21. There was a marked increase in MMP-9 mRNA in the amnion on Day 20, preceding
the appearance of MMP-9 activity. Western blotting confirmed an increase in MMP-9 protein in amnion on Day 21. MMP-2 and MMP-9
activities were detected in extracts of whole yolk sac placenta, placenta, and amniotic fluid, but there were no striking
changes in these gelatinases between Days 18 and 21. However, the capsular regions of the visceral yolk sac placentae, which
thin and rupture during labor, did show higher MMP-9 activity on Day 21 than on Days 18 and 20. We suggest that the striking
increase in MMP-9 expression in amnion and possibly the capsular region of the visceral yolk sac placenta approximately 12
h prior to delivery is responsible, in part, for the alterations in the structure of these fetal membranes before parturition.</description><subject>Amnion - enzymology</subject><subject>Amniotic Fluid - enzymology</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Blotting, Western</subject><subject>Collagenases - biosynthesis</subject><subject>Collagenases - genetics</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>Extracellular Matrix - metabolism</subject><subject>Female</subject><subject>Fetal membranes</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects. Development. Fetal membranes</subject><subject>Labor, Obstetric - physiology</subject><subject>Matrix Metalloproteinase 9</subject><subject>Molecular Sequence Data</subject><subject>Molecular Weight</subject><subject>Placenta - enzymology</subject><subject>Pregnancy</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>RNA, Messenger - analysis</subject><subject>Time Factors</subject><subject>Yolk Sac - enzymology</subject><issn>0006-3363</issn><issn>1529-7268</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kV1LwzAUhoMoc07_gCDkQkUvOtOcNlkvZX7CwBu9Lml7skXTdiYpc__e4IZX5-J9eHl4DyHnKZumrMjvKtNbh2vXNzlM-RSgOCDjNOdFIrmYHZIxY0wkAAKOyYn3n4ylGXAYkZHMikjkY7IqePL1oOgSrQqmUx7pTauCMz-0xaCs7WN9wL8kKW6p8dR0zVBjEy91KlDVdqbvqGlbbIwKaLd07UzvaOjpWrkwOBMicEqOtLIez_Z3Qj6eHt_nL8ni7fl1fr9IVlzkIZEZm-USCi1q4EoyrSvImJ41FdYFi9opzhArVkNUECwFxlPUqLXUNQgUMCHXu97o_T2gD2VrfI3Wqg77wZdSyiznnEXwYg8OVVQvo3Sr3LbcTxPzy32ufK2sdqqrjf_HQEiIZhG72mErs1xtjMPSt3G2WArlZrPJoeRlfAz8As5XgxI</recordid><startdate>19950801</startdate><enddate>19950801</enddate><creator>H Lei</creator><creator>F Vadillo-Ortega</creator><creator>L G Paavola</creator><creator>J F Strauss, 3rd</creator><general>Society for the Study of Reproduction</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19950801</creationdate><title>92-kDa gelatinase (matrix metalloproteinase-9) is induced in rat amnion immediately prior to parturition</title><author>H Lei ; F Vadillo-Ortega ; L G Paavola ; J F Strauss, 3rd</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h265t-74085739f6c32a70ffb340f8dbec907491e8eeb0c3ced6013021efeff7fc36e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Amnion - enzymology</topic><topic>Amniotic Fluid - enzymology</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Blotting, Western</topic><topic>Collagenases - biosynthesis</topic><topic>Collagenases - genetics</topic><topic>Embryology: invertebrates and vertebrates. Teratology</topic><topic>Extracellular Matrix - metabolism</topic><topic>Female</topic><topic>Fetal membranes</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects. Development. Fetal membranes</topic><topic>Labor, Obstetric - physiology</topic><topic>Matrix Metalloproteinase 9</topic><topic>Molecular Sequence Data</topic><topic>Molecular Weight</topic><topic>Placenta - enzymology</topic><topic>Pregnancy</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>RNA, Messenger - analysis</topic><topic>Time Factors</topic><topic>Yolk Sac - enzymology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>H Lei</creatorcontrib><creatorcontrib>F Vadillo-Ortega</creatorcontrib><creatorcontrib>L G Paavola</creatorcontrib><creatorcontrib>J F Strauss, 3rd</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Biology of reproduction</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>H Lei</au><au>F Vadillo-Ortega</au><au>L G Paavola</au><au>J F Strauss, 3rd</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>92-kDa gelatinase (matrix metalloproteinase-9) is induced in rat amnion immediately prior to parturition</atitle><jtitle>Biology of reproduction</jtitle><addtitle>Biol Reprod</addtitle><date>1995-08-01</date><risdate>1995</risdate><volume>53</volume><issue>2</issue><spage>339</spage><epage>344</epage><pages>339-344</pages><issn>0006-3363</issn><eissn>1529-7268</eissn><coden>BIREBV</coden><abstract>The fetal membranes undergo striking changes in structure before delivery that involve catabolism of the extracellular matrix.
To investigate the role of specific enzymes in this process, we examined gelatinase activities in rat amnion, visceral yolk
sac placenta, and placenta and amniotic fluid between Days 18-21 of pregnancy. Matrix metalloproteinase (MMP)-2 was present
in amnion on all days, and its activity increased slightly on Day 21. The 92-kDa gelatinase, MMP-9, was not detected on Days
18-20 but appeared by the morning of Day 21. There was a marked increase in MMP-9 mRNA in the amnion on Day 20, preceding
the appearance of MMP-9 activity. Western blotting confirmed an increase in MMP-9 protein in amnion on Day 21. MMP-2 and MMP-9
activities were detected in extracts of whole yolk sac placenta, placenta, and amniotic fluid, but there were no striking
changes in these gelatinases between Days 18 and 21. However, the capsular regions of the visceral yolk sac placentae, which
thin and rupture during labor, did show higher MMP-9 activity on Day 21 than on Days 18 and 20. We suggest that the striking
increase in MMP-9 expression in amnion and possibly the capsular region of the visceral yolk sac placenta approximately 12
h prior to delivery is responsible, in part, for the alterations in the structure of these fetal membranes before parturition.</abstract><cop>Madison, WI</cop><pub>Society for the Study of Reproduction</pub><pmid>7492685</pmid><doi>10.1095/biolreprod53.2.339</doi><tpages>6</tpages></addata></record> |
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| ispartof | Biology of reproduction, 1995-08, Vol.53 (2), p.339-344 |
| issn | 0006-3363 1529-7268 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77745220 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Amnion - enzymology Amniotic Fluid - enzymology Animals Base Sequence Biological and medical sciences Blotting, Western Collagenases - biosynthesis Collagenases - genetics Embryology: invertebrates and vertebrates. Teratology Extracellular Matrix - metabolism Female Fetal membranes Fundamental and applied biological sciences. Psychology General aspects. Development. Fetal membranes Labor, Obstetric - physiology Matrix Metalloproteinase 9 Molecular Sequence Data Molecular Weight Placenta - enzymology Pregnancy Rats Rats, Sprague-Dawley RNA, Messenger - analysis Time Factors Yolk Sac - enzymology |
| title | 92-kDa gelatinase (matrix metalloproteinase-9) is induced in rat amnion immediately prior to parturition |
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