Activation of Protein Kinase C by Oxidized Diacylglycerols
The effects of 1,2-diacylglycerol hydroperoxide (DAG-OOH), its alcohol (DAG-OH), "unoxidized" 1,2-diacylglycerol (DAG), 1,2-dioleoylglycerol (DOG), and phorbol 12-myristate acetate (PMA) on the activity of protein kinase C (PKC) isolated from rat brain were examined in the presence and abs...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1995-12, Vol.217 (2), p.654-660 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Takekoshi, S. Kambayashi, Y. Nagata, H. Takagi, T. Yamamoto, Y. Watanabe, K. |
| description | The effects of 1,2-diacylglycerol hydroperoxide (DAG-OOH), its alcohol (DAG-OH), "unoxidized" 1,2-diacylglycerol (DAG), 1,2-dioleoylglycerol (DOG), and phorbol 12-myristate acetate (PMA) on the activity of protein kinase C (PKC) isolated from rat brain were examined in the presence and absence of phosphatidylserine (PS) and calcium ion. Both DAG-OOH and DAG-OH stimulated the activity of PKC dose- and time-dependently, The ability of additives for PKC activation increased in the order of DOG, DAG ⪡ DAG-OOH, DAG-OH < PMA. DAG-OOH and DAG-OH activated PKC even in the absence of PS and calcium ion as PMA does. If DAG-OOH and DAG-OH are released from the oxidized biomembranes by the action of phospholipase C, these components may act like PMA and serve to activate the PKC-dependent signal transduction system. |
| doi_str_mv | 10.1006/bbrc.1995.2824 |
| format | Article |
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Both DAG-OOH and DAG-OH stimulated the activity of PKC dose- and time-dependently, The ability of additives for PKC activation increased in the order of DOG, DAG ⪡ DAG-OOH, DAG-OH < PMA. DAG-OOH and DAG-OH activated PKC even in the absence of PS and calcium ion as PMA does. If DAG-OOH and DAG-OH are released from the oxidized biomembranes by the action of phospholipase C, these components may act like PMA and serve to activate the PKC-dependent signal transduction system.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1006/bbrc.1995.2824</identifier><identifier>PMID: 7503748</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Brain - enzymology ; Calcium - physiology ; Diglycerides - chemistry ; Diglycerides - pharmacology ; Enzyme Activation ; Kinetics ; Lipid Peroxides - pharmacology ; Oxidation-Reduction ; Phosphatidylserines - physiology ; Protein Kinase C - metabolism ; Rats ; Reactive Oxygen Species - chemistry ; Receptor, Epidermal Growth Factor - metabolism ; Signal Transduction ; Structure-Activity Relationship</subject><ispartof>Biochemical and biophysical research communications, 1995-12, Vol.217 (2), p.654-660</ispartof><rights>1995 Academic Press</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-3f61710597959394619a64482b6f20a56e73b713bff592b3455fe295a0d5d02a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1006/bbrc.1995.2824$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7503748$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takekoshi, S.</creatorcontrib><creatorcontrib>Kambayashi, Y.</creatorcontrib><creatorcontrib>Nagata, H.</creatorcontrib><creatorcontrib>Takagi, T.</creatorcontrib><creatorcontrib>Yamamoto, Y.</creatorcontrib><creatorcontrib>Watanabe, K.</creatorcontrib><title>Activation of Protein Kinase C by Oxidized Diacylglycerols</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>The effects of 1,2-diacylglycerol hydroperoxide (DAG-OOH), its alcohol (DAG-OH), "unoxidized" 1,2-diacylglycerol (DAG), 1,2-dioleoylglycerol (DOG), and phorbol 12-myristate acetate (PMA) on the activity of protein kinase C (PKC) isolated from rat brain were examined in the presence and absence of phosphatidylserine (PS) and calcium ion. Both DAG-OOH and DAG-OH stimulated the activity of PKC dose- and time-dependently, The ability of additives for PKC activation increased in the order of DOG, DAG ⪡ DAG-OOH, DAG-OH < PMA. DAG-OOH and DAG-OH activated PKC even in the absence of PS and calcium ion as PMA does. If DAG-OOH and DAG-OH are released from the oxidized biomembranes by the action of phospholipase C, these components may act like PMA and serve to activate the PKC-dependent signal transduction system.</description><subject>Animals</subject><subject>Brain - enzymology</subject><subject>Calcium - physiology</subject><subject>Diglycerides - chemistry</subject><subject>Diglycerides - pharmacology</subject><subject>Enzyme Activation</subject><subject>Kinetics</subject><subject>Lipid Peroxides - pharmacology</subject><subject>Oxidation-Reduction</subject><subject>Phosphatidylserines - physiology</subject><subject>Protein Kinase C - metabolism</subject><subject>Rats</subject><subject>Reactive Oxygen Species - chemistry</subject><subject>Receptor, Epidermal Growth Factor - metabolism</subject><subject>Signal Transduction</subject><subject>Structure-Activity Relationship</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kD1PwzAURS0EKqWwsiFlYkt4duw4ZkPlU1QqA0hsluO8IKM0KXZaEX49iVqxMb3hnnuldwg5p5BQgOyqKLxNqFIiYTnjB2RKQUHMKPBDMoWBiJmi78fkJIRPAEp5piZkIgWkkudTcn1jO7c1nWubqK2iF9926Jro2TUmYDSPij5afrvS_WAZ3Tpj-_qj7i36tg6n5KgydcCz_Z2Rt_u71_ljvFg-PM1vFrHlILo4rTIqKQgllVCp4hlVJuM8Z0VWMTAiQ5kWkqZFVQnFipQLUSFTwkApSmAmnZHL3e7at18bDJ1euWCxrk2D7SZoKSUXwGEAkx1ofRuCx0qvvVsZ32sKepSlR1l6lKVHWUPhYr-8KVZY_uF7O0Oe73Ic3ts69DpYh43F0nm0nS5b99_0L-iGdno</recordid><startdate>19951214</startdate><enddate>19951214</enddate><creator>Takekoshi, S.</creator><creator>Kambayashi, Y.</creator><creator>Nagata, H.</creator><creator>Takagi, T.</creator><creator>Yamamoto, Y.</creator><creator>Watanabe, K.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19951214</creationdate><title>Activation of Protein Kinase C by Oxidized Diacylglycerols</title><author>Takekoshi, S. ; Kambayashi, Y. ; Nagata, H. ; Takagi, T. ; Yamamoto, Y. ; Watanabe, K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-3f61710597959394619a64482b6f20a56e73b713bff592b3455fe295a0d5d02a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Brain - enzymology</topic><topic>Calcium - physiology</topic><topic>Diglycerides - chemistry</topic><topic>Diglycerides - pharmacology</topic><topic>Enzyme Activation</topic><topic>Kinetics</topic><topic>Lipid Peroxides - pharmacology</topic><topic>Oxidation-Reduction</topic><topic>Phosphatidylserines - physiology</topic><topic>Protein Kinase C - metabolism</topic><topic>Rats</topic><topic>Reactive Oxygen Species - chemistry</topic><topic>Receptor, Epidermal Growth Factor - metabolism</topic><topic>Signal Transduction</topic><topic>Structure-Activity Relationship</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takekoshi, S.</creatorcontrib><creatorcontrib>Kambayashi, Y.</creatorcontrib><creatorcontrib>Nagata, H.</creatorcontrib><creatorcontrib>Takagi, T.</creatorcontrib><creatorcontrib>Yamamoto, Y.</creatorcontrib><creatorcontrib>Watanabe, K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takekoshi, S.</au><au>Kambayashi, Y.</au><au>Nagata, H.</au><au>Takagi, T.</au><au>Yamamoto, Y.</au><au>Watanabe, K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Activation of Protein Kinase C by Oxidized Diacylglycerols</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>1995-12-14</date><risdate>1995</risdate><volume>217</volume><issue>2</issue><spage>654</spage><epage>660</epage><pages>654-660</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>The effects of 1,2-diacylglycerol hydroperoxide (DAG-OOH), its alcohol (DAG-OH), "unoxidized" 1,2-diacylglycerol (DAG), 1,2-dioleoylglycerol (DOG), and phorbol 12-myristate acetate (PMA) on the activity of protein kinase C (PKC) isolated from rat brain were examined in the presence and absence of phosphatidylserine (PS) and calcium ion. Both DAG-OOH and DAG-OH stimulated the activity of PKC dose- and time-dependently, The ability of additives for PKC activation increased in the order of DOG, DAG ⪡ DAG-OOH, DAG-OH < PMA. DAG-OOH and DAG-OH activated PKC even in the absence of PS and calcium ion as PMA does. If DAG-OOH and DAG-OH are released from the oxidized biomembranes by the action of phospholipase C, these components may act like PMA and serve to activate the PKC-dependent signal transduction system.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>7503748</pmid><doi>10.1006/bbrc.1995.2824</doi><tpages>7</tpages></addata></record> |
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| ispartof | Biochemical and biophysical research communications, 1995-12, Vol.217 (2), p.654-660 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Brain - enzymology Calcium - physiology Diglycerides - chemistry Diglycerides - pharmacology Enzyme Activation Kinetics Lipid Peroxides - pharmacology Oxidation-Reduction Phosphatidylserines - physiology Protein Kinase C - metabolism Rats Reactive Oxygen Species - chemistry Receptor, Epidermal Growth Factor - metabolism Signal Transduction Structure-Activity Relationship |
| title | Activation of Protein Kinase C by Oxidized Diacylglycerols |
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