A structural role for hormone in the thyroid hormone receptor

The crystal structure of the rat aα thyroid hormone receptor ligand-binding domain bound with a thyroid hormone agonist reveals that ligand is completely buried within the domain as part of the hydrophobic core. In addition, the carboxy-terminal activation domain forms an amphi-pathic helix, with it...

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Veröffentlicht in:	Nature (London) 1995-12, Vol.378 (6558), p.690-697
Hauptverfasser:	Wagner, Richard L., Apriletti, James W., McGrath, Mary E., West, Brian L., Baxter, John D., Fletterick, Robert J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Regulation Amino Acid Sequence Amino acids Analytical, structural and metabolic biochemistry Animals Binding and carrier proteins Binding Sites Biological and medical sciences Biophysics Computer Graphics Crystal structure Crystallography, X-Ray Escherichia coli Fundamental and applied biological sciences. Psychology Gene expression Humanities and Social Sciences Humans Ligands Models, Molecular Molecular Sequence Data multidisciplinary Protein Conformation Proteins Rats Receptors, Thyroid Hormone - chemistry Receptors, Thyroid Hormone - physiology Recombinant Proteins - chemistry Science Science (multidisciplinary) Sequence Homology, Amino Acid Structure-Activity Relationship Thyroid Thyroid gland Thyroid Hormones - agonists Thyroid Hormones - chemistry Thyroid Hormones - physiology Transcriptional Activation
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