The liver regenerative response elicited by antisecretory agents in partially hepatectomized rats : a comparison between omeprazole and famotidine
Liver regeneration after omeprazole (OMP) or famotidine (FAM) administration was examined in 66% hepatectomized rats. The regeneration was evaluated by the liver weight as a percentage of body weight (LRR) and the proportion of hepatocytes in mitosis per 1,000 counts (MI). Administration of OMP 0.4...
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| Veröffentlicht in: | Surgery today (Print) 1995-09, Vol.25 (9), p.816-821 |
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| description | Liver regeneration after omeprazole (OMP) or famotidine (FAM) administration was examined in 66% hepatectomized rats. The regeneration was evaluated by the liver weight as a percentage of body weight (LRR) and the proportion of hepatocytes in mitosis per 1,000 counts (MI). Administration of OMP 0.4 mg/kg per day for 3 or 7 days suppressed LRR and MI 3 and 7 days after hepatectomy. However, the administration of FAM 0.8 mg/kg per day for 3 or 7 days did not change either LRR or MI. Increased gastrin levels in the blood were seen only after OMP administration. The food intake was unchanged by OMP or FAM, but FAM increased water intake. The liver functional score, glutamic pyruvic transaminase and alkaline phosphatase in the blood all increased with OMP, but FAM had no apparent effect on the hepatic or renal function. These observations suggest that a large dosage of OMP suppresses liver regeneration, while FAM appears to have no meaningful effect on regeneration. |
| doi_str_mv | 10.1007/BF00311459 |
| format | Article |
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The regeneration was evaluated by the liver weight as a percentage of body weight (LRR) and the proportion of hepatocytes in mitosis per 1,000 counts (MI). Administration of OMP 0.4 mg/kg per day for 3 or 7 days suppressed LRR and MI 3 and 7 days after hepatectomy. However, the administration of FAM 0.8 mg/kg per day for 3 or 7 days did not change either LRR or MI. Increased gastrin levels in the blood were seen only after OMP administration. The food intake was unchanged by OMP or FAM, but FAM increased water intake. The liver functional score, glutamic pyruvic transaminase and alkaline phosphatase in the blood all increased with OMP, but FAM had no apparent effect on the hepatic or renal function. These observations suggest that a large dosage of OMP suppresses liver regeneration, while FAM appears to have no meaningful effect on regeneration.</description><identifier>ISSN: 0941-1291</identifier><identifier>EISSN: 1436-2813</identifier><identifier>DOI: 10.1007/BF00311459</identifier><identifier>PMID: 8555701</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Animals ; Anti-Ulcer Agents - pharmacology ; Biological and medical sciences ; Famotidine - pharmacology ; Gastrins - secretion ; Gastroenterology. Liver. Pancreas. Abdomen ; Hepatectomy ; Kidney Function Tests ; Liver Function Tests ; Liver Regeneration - drug effects ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Mitotic Index - drug effects ; Omeprazole - pharmacology ; Organ Size - drug effects ; Other diseases. 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The regeneration was evaluated by the liver weight as a percentage of body weight (LRR) and the proportion of hepatocytes in mitosis per 1,000 counts (MI). Administration of OMP 0.4 mg/kg per day for 3 or 7 days suppressed LRR and MI 3 and 7 days after hepatectomy. However, the administration of FAM 0.8 mg/kg per day for 3 or 7 days did not change either LRR or MI. Increased gastrin levels in the blood were seen only after OMP administration. The food intake was unchanged by OMP or FAM, but FAM increased water intake. The liver functional score, glutamic pyruvic transaminase and alkaline phosphatase in the blood all increased with OMP, but FAM had no apparent effect on the hepatic or renal function. These observations suggest that a large dosage of OMP suppresses liver regeneration, while FAM appears to have no meaningful effect on regeneration.</description><subject>Animals</subject><subject>Anti-Ulcer Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Famotidine - pharmacology</subject><subject>Gastrins - secretion</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hepatectomy</subject><subject>Kidney Function Tests</subject><subject>Liver Function Tests</subject><subject>Liver Regeneration - drug effects</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mitotic Index - drug effects</subject><subject>Omeprazole - pharmacology</subject><subject>Organ Size - drug effects</subject><subject>Other diseases. Semiology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>0941-1291</issn><issn>1436-2813</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkU9v1DAQxS0EKkvhwh3JB8QBKTD-FyfcoKKAVIlLOUcT74QaOXawvaDtx-ATY9RVOY3evN-8wzzGngt4IwDs2w-XAEoIbcYHbCe06js5CPWQ7WDUohNyFI_Zk1J-AEg9AJyxs8EYY0Hs2J_rG-LB_6LMM32nSBlrU02ULcVCnIJ3vtKez0eOsfpCLlNNuamG18J95Bvm6jGEI7-hDSu5mlZ_225aWOHvOHKX1gb5kiKfqf4mijyttGW8TYFa7p4vuKbq9z7SU_ZowVDo2Wmes2-XH68vPndXXz99uXh_1TmloXbLIHCWDgehbS8kSGXNPBLCMDuYDchxkGpZtOnbchgXdNi7XvXWKjOOiOqcvbrL3XL6eaBSp9UXRyFgpHQok7VWS61MA1_fgS6nUjIt05b9ivk4CZj-FTD9L6DBL06ph3ml_T16-njzX558LA7DkjE6X-4xZWG0EtRfKJ6P2Q</recordid><startdate>199509</startdate><enddate>199509</enddate><creator>AONO, T</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199509</creationdate><title>The liver regenerative response elicited by antisecretory agents in partially hepatectomized rats : a comparison between omeprazole and famotidine</title><author>AONO, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c340t-f81ab2ca814761202375b9ea08bc0b5029823ff4569ea89faca6c636773599aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Anti-Ulcer Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Famotidine - pharmacology</topic><topic>Gastrins - secretion</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Hepatectomy</topic><topic>Kidney Function Tests</topic><topic>Liver Function Tests</topic><topic>Liver Regeneration - drug effects</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mitotic Index - drug effects</topic><topic>Omeprazole - pharmacology</topic><topic>Organ Size - drug effects</topic><topic>Other diseases. Semiology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>AONO, T</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Surgery today (Print)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>AONO, T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The liver regenerative response elicited by antisecretory agents in partially hepatectomized rats : a comparison between omeprazole and famotidine</atitle><jtitle>Surgery today (Print)</jtitle><addtitle>Surg Today</addtitle><date>1995-09</date><risdate>1995</risdate><volume>25</volume><issue>9</issue><spage>816</spage><epage>821</epage><pages>816-821</pages><issn>0941-1291</issn><eissn>1436-2813</eissn><abstract>Liver regeneration after omeprazole (OMP) or famotidine (FAM) administration was examined in 66% hepatectomized rats. The regeneration was evaluated by the liver weight as a percentage of body weight (LRR) and the proportion of hepatocytes in mitosis per 1,000 counts (MI). Administration of OMP 0.4 mg/kg per day for 3 or 7 days suppressed LRR and MI 3 and 7 days after hepatectomy. However, the administration of FAM 0.8 mg/kg per day for 3 or 7 days did not change either LRR or MI. Increased gastrin levels in the blood were seen only after OMP administration. The food intake was unchanged by OMP or FAM, but FAM increased water intake. The liver functional score, glutamic pyruvic transaminase and alkaline phosphatase in the blood all increased with OMP, but FAM had no apparent effect on the hepatic or renal function. These observations suggest that a large dosage of OMP suppresses liver regeneration, while FAM appears to have no meaningful effect on regeneration.</abstract><cop>Heidelberg</cop><cop>Tokyo</cop><pub>Springer</pub><pmid>8555701</pmid><doi>10.1007/BF00311459</doi><tpages>6</tpages></addata></record> |
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| ispartof | Surgery today (Print), 1995-09, Vol.25 (9), p.816-821 |
| issn | 0941-1291 1436-2813 |
| language | eng |
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| subjects | Animals Anti-Ulcer Agents - pharmacology Biological and medical sciences Famotidine - pharmacology Gastrins - secretion Gastroenterology. Liver. Pancreas. Abdomen Hepatectomy Kidney Function Tests Liver Function Tests Liver Regeneration - drug effects Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Mitotic Index - drug effects Omeprazole - pharmacology Organ Size - drug effects Other diseases. Semiology Rats Rats, Wistar |
| title | The liver regenerative response elicited by antisecretory agents in partially hepatectomized rats : a comparison between omeprazole and famotidine |
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