A novel pathway of peptide biosynthesis found in methanogenic Archaea
The peptide subunits of the pseudomurein, the cell-wall peptidoglycan of some methanogens, are usually composed of glutamic acid, alanine and lysine. In order to get a more detailed picture of the biosynthetic pathway of the peptide subunit, we performed in vitro assays. Starting from glutamic acid...
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| Veröffentlicht in: | Archives of microbiology 1994-12, Vol.162 (6), p.430-432 |
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| creator | HARTMANN, E KÖNIG, H |
| description | The peptide subunits of the pseudomurein, the cell-wall peptidoglycan of some methanogens, are usually composed of glutamic acid, alanine and lysine. In order to get a more detailed picture of the biosynthetic pathway of the peptide subunit, we performed in vitro assays. Starting from glutamic acid a pentapeptide was obtained in seven steps: [formula: see text] The pentapeptide structure was identical to that of the peptide subunit of the intact pseudomurein except one additional alanine residue, which is split off during further processing. The pentapeptide synthesis starts with glutamic acid, which is phosphorylated at the N alpha-amino group. N alpha-phosphoryl-glutamic acid is transferred to a nucleotide-carrier, forming N alpha-UDP-glutamic acid. The further pentapeptide biosynthesis is achieved via a di-, tri- and tetrapeptide by stepwise addition of the corresponding amino acids. |
| doi_str_mv | 10.1007/BF00282108 |
| format | Article |
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In order to get a more detailed picture of the biosynthetic pathway of the peptide subunit, we performed in vitro assays. Starting from glutamic acid a pentapeptide was obtained in seven steps: [formula: see text] The pentapeptide structure was identical to that of the peptide subunit of the intact pseudomurein except one additional alanine residue, which is split off during further processing. The pentapeptide synthesis starts with glutamic acid, which is phosphorylated at the N alpha-amino group. N alpha-phosphoryl-glutamic acid is transferred to a nucleotide-carrier, forming N alpha-UDP-glutamic acid. The further pentapeptide biosynthesis is achieved via a di-, tri- and tetrapeptide by stepwise addition of the corresponding amino acids.</description><identifier>ISSN: 0302-8933</identifier><identifier>EISSN: 1432-072X</identifier><identifier>DOI: 10.1007/BF00282108</identifier><identifier>PMID: 7872839</identifier><identifier>CODEN: AMICCW</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Biological and medical sciences ; Biology of microorganisms of confirmed or potential industrial interest ; Biotechnology ; Cell Wall - metabolism ; Fundamental and applied biological sciences. 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In order to get a more detailed picture of the biosynthetic pathway of the peptide subunit, we performed in vitro assays. Starting from glutamic acid a pentapeptide was obtained in seven steps: [formula: see text] The pentapeptide structure was identical to that of the peptide subunit of the intact pseudomurein except one additional alanine residue, which is split off during further processing. The pentapeptide synthesis starts with glutamic acid, which is phosphorylated at the N alpha-amino group. N alpha-phosphoryl-glutamic acid is transferred to a nucleotide-carrier, forming N alpha-UDP-glutamic acid. The further pentapeptide biosynthesis is achieved via a di-, tri- and tetrapeptide by stepwise addition of the corresponding amino acids.</description><subject>Biological and medical sciences</subject><subject>Biology of microorganisms of confirmed or potential industrial interest</subject><subject>Biotechnology</subject><subject>Cell Wall - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glutamic Acid - metabolism</subject><subject>Methanobacterium - metabolism</subject><subject>Mission oriented research</subject><subject>Peptidoglycan - biosynthesis</subject><subject>Peptidoglycan - chemistry</subject><subject>Physiology and metabolism</subject><issn>0302-8933</issn><issn>1432-072X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMFLwzAYxYMoc04v3oUcxINQ_ZJ0JjnOsakw8KLgrXxJU1vpktq0yv57K5Z5eof34_H4EXLO4IYByNv7NQBXnIE6IFOWCp6A5G-HZAoCeKK0EMfkJMYPAMaVUhMykUpyJfSUrBbUhy9X0wa78ht3NBS0cU1X5Y6aKsSd70oXq0iL0PucVp5uXVeiD-_OV5YuWluiw1NyVGAd3dmYM_K6Xr0sH5PN88PTcrFJrGCsS7gC1JjmGtAUhgkhjAKuBZi5tjJ1DhVDpQw4O9zUKp1bzQ1aY9NCAWgxI1d_u00bPnsXu2xbRevqGr0LfcyklClTAgbw-g-0bYixdUXWtNUW213GIPt1lv07G-CLcbU3W5fv0VHS0F-OPUaLddGit1XcY0LM0_ROix_hRnJ0</recordid><startdate>19941201</startdate><enddate>19941201</enddate><creator>HARTMANN, E</creator><creator>KÖNIG, H</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19941201</creationdate><title>A novel pathway of peptide biosynthesis found in methanogenic Archaea</title><author>HARTMANN, E ; KÖNIG, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-280a9a4d90abfb1333b802930b59c74eea81a88b0ec8889845c92bacbc4f80093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Biological and medical sciences</topic><topic>Biology of microorganisms of confirmed or potential industrial interest</topic><topic>Biotechnology</topic><topic>Cell Wall - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glutamic Acid - metabolism</topic><topic>Methanobacterium - metabolism</topic><topic>Mission oriented research</topic><topic>Peptidoglycan - biosynthesis</topic><topic>Peptidoglycan - chemistry</topic><topic>Physiology and metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HARTMANN, E</creatorcontrib><creatorcontrib>KÖNIG, H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HARTMANN, E</au><au>KÖNIG, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A novel pathway of peptide biosynthesis found in methanogenic Archaea</atitle><jtitle>Archives of microbiology</jtitle><addtitle>Arch Microbiol</addtitle><date>1994-12-01</date><risdate>1994</risdate><volume>162</volume><issue>6</issue><spage>430</spage><epage>432</epage><pages>430-432</pages><issn>0302-8933</issn><eissn>1432-072X</eissn><coden>AMICCW</coden><abstract>The peptide subunits of the pseudomurein, the cell-wall peptidoglycan of some methanogens, are usually composed of glutamic acid, alanine and lysine. In order to get a more detailed picture of the biosynthetic pathway of the peptide subunit, we performed in vitro assays. Starting from glutamic acid a pentapeptide was obtained in seven steps: [formula: see text] The pentapeptide structure was identical to that of the peptide subunit of the intact pseudomurein except one additional alanine residue, which is split off during further processing. The pentapeptide synthesis starts with glutamic acid, which is phosphorylated at the N alpha-amino group. N alpha-phosphoryl-glutamic acid is transferred to a nucleotide-carrier, forming N alpha-UDP-glutamic acid. The further pentapeptide biosynthesis is achieved via a di-, tri- and tetrapeptide by stepwise addition of the corresponding amino acids.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><pub>Springer</pub><pmid>7872839</pmid><doi>10.1007/BF00282108</doi><tpages>3</tpages></addata></record> |
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| ispartof | Archives of microbiology, 1994-12, Vol.162 (6), p.430-432 |
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| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Biological and medical sciences Biology of microorganisms of confirmed or potential industrial interest Biotechnology Cell Wall - metabolism Fundamental and applied biological sciences. Psychology Glutamic Acid - metabolism Methanobacterium - metabolism Mission oriented research Peptidoglycan - biosynthesis Peptidoglycan - chemistry Physiology and metabolism |
| title | A novel pathway of peptide biosynthesis found in methanogenic Archaea |
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