Pressure-induced mechanical stress in the carotid artery bifurcation: A possible correlation to atherosclerosis
A possible correlation between regions of high intramural wall stress and the development of atherosclerotic lesions in the carotid artery bifurcation is investigated. The bifurcation geometry is determined through in vivo studies, as well as the analysis of cadaver specimens. Having compiled accura...
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| Veröffentlicht in: | Journal of biomechanics 1995-11, Vol.28 (11), p.1333-1340 |
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| container_title | Journal of biomechanics |
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| creator | Salzar, Robert S. Thubrikar, Mano J. Eppink, Richard T. |
| description | A possible correlation between regions of high intramural wall stress and the development of atherosclerotic lesions in the carotid artery bifurcation is investigated. The bifurcation geometry is determined through
in vivo studies, as well as the analysis of cadaver specimens. Having compiled accurate geometric data, two representative finite element models were created in order to determine the areas of localized stress concentrations that occur in the bifurcation. The artery is assumed isotropic and is mechanically loaded with an incremental pressure of 40 mmHg. A highly localized stress concentration of approximately 9 to 14 times the proximal circumferential wall stress occurs at the point of bifurcation. A lower stress concentration of approximately 3 to 4 times the proximal cirumferential stress occurs over a large area of the sinus bulb. Acknowledging that these two regions of the carotid bifurcation are highly susceptible to atherosclerotic lesions, it appears possible that a correlation between wall stress and atherosclerosis may exist. |
| doi_str_mv | 10.1016/0021-9290(95)00005-3 |
| format | Article |
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in vivo studies, as well as the analysis of cadaver specimens. Having compiled accurate geometric data, two representative finite element models were created in order to determine the areas of localized stress concentrations that occur in the bifurcation. The artery is assumed isotropic and is mechanically loaded with an incremental pressure of 40 mmHg. A highly localized stress concentration of approximately 9 to 14 times the proximal circumferential wall stress occurs at the point of bifurcation. A lower stress concentration of approximately 3 to 4 times the proximal cirumferential stress occurs over a large area of the sinus bulb. Acknowledging that these two regions of the carotid bifurcation are highly susceptible to atherosclerotic lesions, it appears possible that a correlation between wall stress and atherosclerosis may exist.</description><identifier>ISSN: 0021-9290</identifier><identifier>EISSN: 1873-2380</identifier><identifier>DOI: 10.1016/0021-9290(95)00005-3</identifier><identifier>PMID: 8522546</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>Angiography ; Arteriosclerosis - etiology ; Arteriosclerosis - pathology ; Artery ; Atherosclerosis ; Bifurcation ; Blood Pressure ; Calcinosis - pathology ; Carotid Artery Diseases - etiology ; Carotid Artery Diseases - pathology ; Carotid Artery, Common - anatomy & histology ; Carotid Artery, Common - physiology ; Carotid Artery, External - anatomy & histology ; Carotid Artery, External - physiology ; Carotid Artery, Internal - anatomy & histology ; Carotid Artery, Internal - physiology ; Disease Susceptibility ; Endothelium, Vascular - pathology ; Foam Cells - pathology ; Hemorheology ; Humans ; Magnetic Resonance Imaging ; Models, Biological ; Photography ; Replica Techniques ; Stress, Mechanical ; Tunica Intima - pathology ; Wall stress</subject><ispartof>Journal of biomechanics, 1995-11, Vol.28 (11), p.1333-1340</ispartof><rights>1995</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-1c5b9afb9b2ab3321d6c55c8763a05abe2b5af6f0fbdd3ebdb35e8055fe33db03</citedby><cites>FETCH-LOGICAL-c454t-1c5b9afb9b2ab3321d6c55c8763a05abe2b5af6f0fbdd3ebdb35e8055fe33db03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0021929095000053$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8522546$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Salzar, Robert S.</creatorcontrib><creatorcontrib>Thubrikar, Mano J.</creatorcontrib><creatorcontrib>Eppink, Richard T.</creatorcontrib><title>Pressure-induced mechanical stress in the carotid artery bifurcation: A possible correlation to atherosclerosis</title><title>Journal of biomechanics</title><addtitle>J Biomech</addtitle><description>A possible correlation between regions of high intramural wall stress and the development of atherosclerotic lesions in the carotid artery bifurcation is investigated. The bifurcation geometry is determined through
in vivo studies, as well as the analysis of cadaver specimens. Having compiled accurate geometric data, two representative finite element models were created in order to determine the areas of localized stress concentrations that occur in the bifurcation. The artery is assumed isotropic and is mechanically loaded with an incremental pressure of 40 mmHg. A highly localized stress concentration of approximately 9 to 14 times the proximal circumferential wall stress occurs at the point of bifurcation. A lower stress concentration of approximately 3 to 4 times the proximal cirumferential stress occurs over a large area of the sinus bulb. Acknowledging that these two regions of the carotid bifurcation are highly susceptible to atherosclerotic lesions, it appears possible that a correlation between wall stress and atherosclerosis may exist.</description><subject>Angiography</subject><subject>Arteriosclerosis - etiology</subject><subject>Arteriosclerosis - pathology</subject><subject>Artery</subject><subject>Atherosclerosis</subject><subject>Bifurcation</subject><subject>Blood Pressure</subject><subject>Calcinosis - pathology</subject><subject>Carotid Artery Diseases - etiology</subject><subject>Carotid Artery Diseases - pathology</subject><subject>Carotid Artery, Common - anatomy & histology</subject><subject>Carotid Artery, Common - physiology</subject><subject>Carotid Artery, External - anatomy & histology</subject><subject>Carotid Artery, External - physiology</subject><subject>Carotid Artery, Internal - anatomy & histology</subject><subject>Carotid Artery, Internal - physiology</subject><subject>Disease Susceptibility</subject><subject>Endothelium, Vascular - pathology</subject><subject>Foam Cells - pathology</subject><subject>Hemorheology</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Models, Biological</subject><subject>Photography</subject><subject>Replica Techniques</subject><subject>Stress, Mechanical</subject><subject>Tunica Intima - pathology</subject><subject>Wall stress</subject><issn>0021-9290</issn><issn>1873-2380</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtLxDAUhYMoOj7-gUJWootq0jR9uBBk8AUDutB1yOMWI20zJqkw_950ZnCpWSSQ850bcg5Cp5RcUULLa0JymjV5Qy4afknS4hnbQTNaVyzLWU120ewXOUCHIXwmpiqqZh_t1zzPeVHOkHv1EMLoIbODGTUY3IP-kIPVssMhTiK2A44fgLX0LlqDpY_gV1jZdvRaRuuGG3yHly4Eq7qEOe-hW9_j6LBMVu-C7qbdhmO018ouwMn2PELvD_dv86ds8fL4PL9bZLrgRcyo5qqRrWpULhVjOTWl5lzXVckk4VJBrrhsy5a0yhgGyijGoSact8CYUYQdofPN3KV3XyOEKHobNHSdHMCNQVRVVRDelP-ClJd1mdJKYLEBdfpI8NCKpbe99CtBiZgKEVPaYkpbNFysCxEs2c6280fVg_k1bRtI-u1Gh5TGtwUvgrYwpCasBx2FcfbvB34A3TudLw</recordid><startdate>19951101</startdate><enddate>19951101</enddate><creator>Salzar, Robert S.</creator><creator>Thubrikar, Mano J.</creator><creator>Eppink, Richard T.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19951101</creationdate><title>Pressure-induced mechanical stress in the carotid artery bifurcation: A possible correlation to atherosclerosis</title><author>Salzar, Robert S. ; Thubrikar, Mano J. ; Eppink, Richard T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-1c5b9afb9b2ab3321d6c55c8763a05abe2b5af6f0fbdd3ebdb35e8055fe33db03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Angiography</topic><topic>Arteriosclerosis - etiology</topic><topic>Arteriosclerosis - pathology</topic><topic>Artery</topic><topic>Atherosclerosis</topic><topic>Bifurcation</topic><topic>Blood Pressure</topic><topic>Calcinosis - pathology</topic><topic>Carotid Artery Diseases - etiology</topic><topic>Carotid Artery Diseases - pathology</topic><topic>Carotid Artery, Common - anatomy & histology</topic><topic>Carotid Artery, Common - physiology</topic><topic>Carotid Artery, External - anatomy & histology</topic><topic>Carotid Artery, External - physiology</topic><topic>Carotid Artery, Internal - anatomy & histology</topic><topic>Carotid Artery, Internal - physiology</topic><topic>Disease Susceptibility</topic><topic>Endothelium, Vascular - pathology</topic><topic>Foam Cells - pathology</topic><topic>Hemorheology</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Models, Biological</topic><topic>Photography</topic><topic>Replica Techniques</topic><topic>Stress, Mechanical</topic><topic>Tunica Intima - pathology</topic><topic>Wall stress</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Salzar, Robert S.</creatorcontrib><creatorcontrib>Thubrikar, Mano J.</creatorcontrib><creatorcontrib>Eppink, Richard T.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of biomechanics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Salzar, Robert S.</au><au>Thubrikar, Mano J.</au><au>Eppink, Richard T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pressure-induced mechanical stress in the carotid artery bifurcation: A possible correlation to atherosclerosis</atitle><jtitle>Journal of biomechanics</jtitle><addtitle>J Biomech</addtitle><date>1995-11-01</date><risdate>1995</risdate><volume>28</volume><issue>11</issue><spage>1333</spage><epage>1340</epage><pages>1333-1340</pages><issn>0021-9290</issn><eissn>1873-2380</eissn><abstract>A possible correlation between regions of high intramural wall stress and the development of atherosclerotic lesions in the carotid artery bifurcation is investigated. The bifurcation geometry is determined through
in vivo studies, as well as the analysis of cadaver specimens. Having compiled accurate geometric data, two representative finite element models were created in order to determine the areas of localized stress concentrations that occur in the bifurcation. The artery is assumed isotropic and is mechanically loaded with an incremental pressure of 40 mmHg. A highly localized stress concentration of approximately 9 to 14 times the proximal circumferential wall stress occurs at the point of bifurcation. A lower stress concentration of approximately 3 to 4 times the proximal cirumferential stress occurs over a large area of the sinus bulb. Acknowledging that these two regions of the carotid bifurcation are highly susceptible to atherosclerotic lesions, it appears possible that a correlation between wall stress and atherosclerosis may exist.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>8522546</pmid><doi>10.1016/0021-9290(95)00005-3</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Angiography Arteriosclerosis - etiology Arteriosclerosis - pathology Artery Atherosclerosis Bifurcation Blood Pressure Calcinosis - pathology Carotid Artery Diseases - etiology Carotid Artery Diseases - pathology Carotid Artery, Common - anatomy & histology Carotid Artery, Common - physiology Carotid Artery, External - anatomy & histology Carotid Artery, External - physiology Carotid Artery, Internal - anatomy & histology Carotid Artery, Internal - physiology Disease Susceptibility Endothelium, Vascular - pathology Foam Cells - pathology Hemorheology Humans Magnetic Resonance Imaging Models, Biological Photography Replica Techniques Stress, Mechanical Tunica Intima - pathology Wall stress |
| title | Pressure-induced mechanical stress in the carotid artery bifurcation: A possible correlation to atherosclerosis |
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