The composition of individual molecular species of plasma phosphatidylcholine in human pregnancy
The molecular species composition of plasma phosphatidylcholine (PC) was measured in sequential blood samples from 13 pregnant women from 16 weeks of gestation to delivery at term. The increased total plasma PC concentration at term was due solely to increased concentrations of individual species co...
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| Veröffentlicht in: | Early human development 1995-08, Vol.43 (1), p.47-58 |
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| creator | Postle, Anthony D. Al, Monique D.M. Burdge, Graham C. Hornstra, Gerard |
| description | The molecular species composition of plasma phosphatidylcholine (PC) was measured in sequential blood samples from 13 pregnant women from 16 weeks of gestation to delivery at term. The increased total plasma PC concentration at term was due solely to increased concentrations of individual species containing palmitate (16:0) rather than stearate (18:0) at the
sn-1 position. The specific increase of
PC16:0
22:6
concentration in mid-gestation suggests that adaptations to maternal hepatic PC metabolism may provide a mechanism to ensure adequate supply of 22:6(
n-3) to the fetus. While cord plasma PC was comparable to liver PC composition from three stillborn term infants, the compositions of these tissues differed from maternal plasma PC, which contained significantly more
PC16:0
18:2
and
PC18:0
18:2
. These results suggest that, although fetal acquisition of polyunsaturated fatty acids (PUFA) is dependent on the maternal lipid supply, the detailed composition of fetal plasma PC may be regulated largely by intrinsic fetal mechanisms such as placental and liver PC metabolism. Similarly, the specific alterations to maternal plasma PC composition in pregnancy, which we postulate are associated with the supply of PUFA to the fetus, were substantially independent of variations in maternal dietary lipid nutrition. |
| doi_str_mv | 10.1016/0378-3782(95)01663-N |
| format | Article |
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sn-1 position. The specific increase of
PC16:0
22:6
concentration in mid-gestation suggests that adaptations to maternal hepatic PC metabolism may provide a mechanism to ensure adequate supply of 22:6(
n-3) to the fetus. While cord plasma PC was comparable to liver PC composition from three stillborn term infants, the compositions of these tissues differed from maternal plasma PC, which contained significantly more
PC16:0
18:2
and
PC18:0
18:2
. These results suggest that, although fetal acquisition of polyunsaturated fatty acids (PUFA) is dependent on the maternal lipid supply, the detailed composition of fetal plasma PC may be regulated largely by intrinsic fetal mechanisms such as placental and liver PC metabolism. Similarly, the specific alterations to maternal plasma PC composition in pregnancy, which we postulate are associated with the supply of PUFA to the fetus, were substantially independent of variations in maternal dietary lipid nutrition.</description><identifier>ISSN: 0378-3782</identifier><identifier>EISSN: 1872-6232</identifier><identifier>DOI: 10.1016/0378-3782(95)01663-N</identifier><identifier>PMID: 8575351</identifier><identifier>CODEN: EHDEDN</identifier><language>eng</language><publisher>Lausanne: Elsevier Ireland Ltd</publisher><subject>Biological and medical sciences ; Chromatography, High Pressure Liquid ; Docosahexaenoic acid ; Fatty Acids, Omega-3 - metabolism ; Fatty Acids, Unsaturated - analysis ; Fatty Acids, Unsaturated - metabolism ; Female ; Fetal Blood - chemistry ; Fetus - metabolism ; Fundamental and applied biological sciences. Psychology ; Human pregnancy ; Humans ; Infant, Newborn ; Liver - embryology ; Liver - metabolism ; Longitudinal Studies ; Male ; Mammalian female genital system ; Maternal-Fetal Exchange ; Morphology. Physiology ; Neonatal liver ; Palmitates - analysis ; Palmitates - metabolism ; Phosphatidylcholine molecular species ; Phosphatidylcholines - blood ; Phosphatidylcholines - chemistry ; Phosphatidylcholines - metabolism ; Placenta - metabolism ; Plasma phosphatidylcholine ; Pregnancy - blood ; Prospective Studies ; Stearates - analysis ; Stearates - metabolism ; Vertebrates: reproduction</subject><ispartof>Early human development, 1995-08, Vol.43 (1), p.47-58</ispartof><rights>1995</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-c4835b8d4a610ec49cf30c46743505592a2adab45ef3aa30aaceecf1ce2802f3</citedby><cites>FETCH-LOGICAL-c386t-c4835b8d4a610ec49cf30c46743505592a2adab45ef3aa30aaceecf1ce2802f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0378-3782(95)01663-N$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,3548,23928,23929,25138,27922,27923,45993</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3690951$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8575351$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Postle, Anthony D.</creatorcontrib><creatorcontrib>Al, Monique D.M.</creatorcontrib><creatorcontrib>Burdge, Graham C.</creatorcontrib><creatorcontrib>Hornstra, Gerard</creatorcontrib><title>The composition of individual molecular species of plasma phosphatidylcholine in human pregnancy</title><title>Early human development</title><addtitle>Early Hum Dev</addtitle><description>The molecular species composition of plasma phosphatidylcholine (PC) was measured in sequential blood samples from 13 pregnant women from 16 weeks of gestation to delivery at term. The increased total plasma PC concentration at term was due solely to increased concentrations of individual species containing palmitate (16:0) rather than stearate (18:0) at the
sn-1 position. The specific increase of
PC16:0
22:6
concentration in mid-gestation suggests that adaptations to maternal hepatic PC metabolism may provide a mechanism to ensure adequate supply of 22:6(
n-3) to the fetus. While cord plasma PC was comparable to liver PC composition from three stillborn term infants, the compositions of these tissues differed from maternal plasma PC, which contained significantly more
PC16:0
18:2
and
PC18:0
18:2
. These results suggest that, although fetal acquisition of polyunsaturated fatty acids (PUFA) is dependent on the maternal lipid supply, the detailed composition of fetal plasma PC may be regulated largely by intrinsic fetal mechanisms such as placental and liver PC metabolism. Similarly, the specific alterations to maternal plasma PC composition in pregnancy, which we postulate are associated with the supply of PUFA to the fetus, were substantially independent of variations in maternal dietary lipid nutrition.</description><subject>Biological and medical sciences</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Docosahexaenoic acid</subject><subject>Fatty Acids, Omega-3 - metabolism</subject><subject>Fatty Acids, Unsaturated - analysis</subject><subject>Fatty Acids, Unsaturated - metabolism</subject><subject>Female</subject><subject>Fetal Blood - chemistry</subject><subject>Fetus - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Human pregnancy</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Liver - embryology</subject><subject>Liver - metabolism</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Mammalian female genital system</subject><subject>Maternal-Fetal Exchange</subject><subject>Morphology. Physiology</subject><subject>Neonatal liver</subject><subject>Palmitates - analysis</subject><subject>Palmitates - metabolism</subject><subject>Phosphatidylcholine molecular species</subject><subject>Phosphatidylcholines - blood</subject><subject>Phosphatidylcholines - chemistry</subject><subject>Phosphatidylcholines - metabolism</subject><subject>Placenta - metabolism</subject><subject>Plasma phosphatidylcholine</subject><subject>Pregnancy - blood</subject><subject>Prospective Studies</subject><subject>Stearates - analysis</subject><subject>Stearates - metabolism</subject><subject>Vertebrates: reproduction</subject><issn>0378-3782</issn><issn>1872-6232</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1q3DAURkVJSCfTvkELXpSSLJzKkuWfTaAMbRMIyWb26p3r61hBtlzJDszbV84Ms8xCCPSd70o6jH3J-E3Gs-IHl2WVxiWuanUdDwqZPn5gq6wqRVoIKc7Y6oR8ZJchvHDOVVXzC3ZRqVJJla3Y321HCbp-dMFMxg2JaxMzNObVNDPYpHeWcLbgkzASGgpLPloIPSRj58LYwWSavcXOWTNQrCbd3MOQjJ6eBxhw_4mdt2ADfT7ua7b9_Wu7uUsfnv7cb34-pCirYkoxr6TaVU0ORcYJ8xpbyTEvylwqrlQtQEADu1xRKwEkB0AibDMkUXHRyjX7fhg7evdvpjDp3gQka2EgNwddlmW8R4gI5gcQvQvBU6tHb3rwe51xvXjVizS9SNO10m9e9WOsfT3On3c9NafSUWTMvx1zCAi29fHvJpwwWdS8fsNuDxhFFa-GvA7R6oDUGE846caZ99_xH-tLln8</recordid><startdate>19950830</startdate><enddate>19950830</enddate><creator>Postle, Anthony D.</creator><creator>Al, Monique D.M.</creator><creator>Burdge, Graham C.</creator><creator>Hornstra, Gerard</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19950830</creationdate><title>The composition of individual molecular species of plasma phosphatidylcholine in human pregnancy</title><author>Postle, Anthony D. ; Al, Monique D.M. ; Burdge, Graham C. ; Hornstra, Gerard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-c4835b8d4a610ec49cf30c46743505592a2adab45ef3aa30aaceecf1ce2802f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Biological and medical sciences</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Docosahexaenoic acid</topic><topic>Fatty Acids, Omega-3 - metabolism</topic><topic>Fatty Acids, Unsaturated - analysis</topic><topic>Fatty Acids, Unsaturated - metabolism</topic><topic>Female</topic><topic>Fetal Blood - chemistry</topic><topic>Fetus - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Human pregnancy</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Liver - embryology</topic><topic>Liver - metabolism</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Mammalian female genital system</topic><topic>Maternal-Fetal Exchange</topic><topic>Morphology. Physiology</topic><topic>Neonatal liver</topic><topic>Palmitates - analysis</topic><topic>Palmitates - metabolism</topic><topic>Phosphatidylcholine molecular species</topic><topic>Phosphatidylcholines - blood</topic><topic>Phosphatidylcholines - chemistry</topic><topic>Phosphatidylcholines - metabolism</topic><topic>Placenta - metabolism</topic><topic>Plasma phosphatidylcholine</topic><topic>Pregnancy - blood</topic><topic>Prospective Studies</topic><topic>Stearates - analysis</topic><topic>Stearates - metabolism</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Postle, Anthony D.</creatorcontrib><creatorcontrib>Al, Monique D.M.</creatorcontrib><creatorcontrib>Burdge, Graham C.</creatorcontrib><creatorcontrib>Hornstra, Gerard</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Early human development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Postle, Anthony D.</au><au>Al, Monique D.M.</au><au>Burdge, Graham C.</au><au>Hornstra, Gerard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The composition of individual molecular species of plasma phosphatidylcholine in human pregnancy</atitle><jtitle>Early human development</jtitle><addtitle>Early Hum Dev</addtitle><date>1995-08-30</date><risdate>1995</risdate><volume>43</volume><issue>1</issue><spage>47</spage><epage>58</epage><pages>47-58</pages><issn>0378-3782</issn><eissn>1872-6232</eissn><coden>EHDEDN</coden><abstract>The molecular species composition of plasma phosphatidylcholine (PC) was measured in sequential blood samples from 13 pregnant women from 16 weeks of gestation to delivery at term. The increased total plasma PC concentration at term was due solely to increased concentrations of individual species containing palmitate (16:0) rather than stearate (18:0) at the
sn-1 position. The specific increase of
PC16:0
22:6
concentration in mid-gestation suggests that adaptations to maternal hepatic PC metabolism may provide a mechanism to ensure adequate supply of 22:6(
n-3) to the fetus. While cord plasma PC was comparable to liver PC composition from three stillborn term infants, the compositions of these tissues differed from maternal plasma PC, which contained significantly more
PC16:0
18:2
and
PC18:0
18:2
. These results suggest that, although fetal acquisition of polyunsaturated fatty acids (PUFA) is dependent on the maternal lipid supply, the detailed composition of fetal plasma PC may be regulated largely by intrinsic fetal mechanisms such as placental and liver PC metabolism. Similarly, the specific alterations to maternal plasma PC composition in pregnancy, which we postulate are associated with the supply of PUFA to the fetus, were substantially independent of variations in maternal dietary lipid nutrition.</abstract><cop>Lausanne</cop><cop>New York,NY</cop><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>8575351</pmid><doi>10.1016/0378-3782(95)01663-N</doi><tpages>12</tpages></addata></record> |
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| ispartof | Early human development, 1995-08, Vol.43 (1), p.47-58 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Biological and medical sciences Chromatography, High Pressure Liquid Docosahexaenoic acid Fatty Acids, Omega-3 - metabolism Fatty Acids, Unsaturated - analysis Fatty Acids, Unsaturated - metabolism Female Fetal Blood - chemistry Fetus - metabolism Fundamental and applied biological sciences. Psychology Human pregnancy Humans Infant, Newborn Liver - embryology Liver - metabolism Longitudinal Studies Male Mammalian female genital system Maternal-Fetal Exchange Morphology. Physiology Neonatal liver Palmitates - analysis Palmitates - metabolism Phosphatidylcholine molecular species Phosphatidylcholines - blood Phosphatidylcholines - chemistry Phosphatidylcholines - metabolism Placenta - metabolism Plasma phosphatidylcholine Pregnancy - blood Prospective Studies Stearates - analysis Stearates - metabolism Vertebrates: reproduction |
| title | The composition of individual molecular species of plasma phosphatidylcholine in human pregnancy |
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