Growth-inhibitory properties of novel anthracyclines in human leukemic cell lines expressing either Pgp-MDR or at-MDR

The objective of the experiments reported in this paper was the identification of promising anthracycline analogs on the basis of lack of cross-resistance against tumor cells presenting either P-glycoprotein multidrug resistance (Pgp-MDR) or the altered topoisomerase multidrug resistant (at-MDR) phe...

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Veröffentlicht in:	Investigational new drugs 1994-01, Vol.12 (2), p.93-97
Hauptverfasser:	MARIANI, M, CAPOLONGO, L, SUARATO, A, BARGIOTTI, A, MONGELLI, N, GRANDI, M, BECK, W. T
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, Antineoplastic - chemistry Antibiotics, Antineoplastic - pharmacology Antineoplastic agents ATP-Binding Cassette, Sub-Family B, Member 1 - biosynthesis Biological and medical sciences Cell Division - drug effects Chemotherapy DNA Topoisomerases, Type II - metabolism Drug Resistance, Multiple - physiology Humans Leukemia - drug therapy Medical sciences Pharmacology. Drug treatments Structure-Activity Relationship Tumor Cells, Cultured
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