Carbamylation of proteins and atherogenesis in renal failure
The incidence of atherosclerosis is greatly increased in patients with chronic renal failure, and this increased risk is only partly explained by conventional risk factors. Carbamylation of proteins occurs in renal failure as a result of reactions between urea-derived cyanate and protein amino group...
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| Veröffentlicht in: | Medical hypotheses 1995-08, Vol.45 (2), p.125-128 |
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| container_end_page | 128 |
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| container_title | Medical hypotheses |
| container_volume | 45 |
| creator | Roxborough, H.E. Young, I.S. |
| description | The incidence of atherosclerosis is greatly increased in patients with chronic renal failure, and this increased risk is only partly explained by conventional risk factors. Carbamylation of proteins occurs in renal failure as a result of reactions between urea-derived cyanate and protein amino groups. A mechanism is proposed whereby oxidation of LDL cholesterol within the arterial wall may be enhanced as a result of carbamylation. This may be accentuated as a result of inhibition of antioxidant enzymes by carbamylation. The combination of these processes may lead to increased atherogenesis. |
| doi_str_mv | 10.1016/0306-9877(95)90059-4 |
| format | Article |
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Vascular system</subject><subject>Cholesterol, LDL - metabolism</subject><subject>Cyanates - metabolism</subject><subject>Humans</subject><subject>Kidney Failure, Chronic - metabolism</subject><subject>Kidney Failure, Chronic - physiopathology</subject><subject>Medical sciences</subject><subject>Models, Biological</subject><subject>Oxidation-Reduction</subject><subject>Risk Factors</subject><issn>0306-9877</issn><issn>1532-2777</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMotVb_gcIeRPSwmmySTQIiSPELBC96DtPsRCPbbE22gv_erS09eprD-8zwzkPIMaOXjLL6inJal0YrdW7khaFUmlLskDGTvCorpdQuGW-RfXKQ8yel1AiuR2SkJWea8zG5nkKawfynhT50seh8sUhdjyHmAmJTQP-BqXvHiDnkIsQiYYS28BDaZcJDsuehzXi0mRPydn_3On0sn18enqa3z6UTsupLT03NHTrU3IBRzs80Slp7zirTVJUGUQGTqEDOvOdGYa0qIXitQUunjOYTcra-O3T7WmLu7Txkh20LEbtltsOzvJaaDaBYgy51OSf0dpHCHNKPZdSupNmVEbsyYo20f9KsGNZONveXszk226WNpSE_3eSQHbQ-QXQhbzFeK6WFGrCbNYaDi--AyWYXMDpsQkLX26YL__f4BbYNh4Y</recordid><startdate>19950801</startdate><enddate>19950801</enddate><creator>Roxborough, H.E.</creator><creator>Young, I.S.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19950801</creationdate><title>Carbamylation of proteins and atherogenesis in renal failure</title><author>Roxborough, H.E. ; Young, I.S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-f0963cece839a97cfb8e506f3129d228a42a15e7a5bff397e67244368a85c7983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Arteriosclerosis - epidemiology</topic><topic>Arteriosclerosis - metabolism</topic><topic>Arteriosclerosis - physiopathology</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. 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| fulltext | fulltext |
| identifier | ISSN: 0306-9877 |
| ispartof | Medical hypotheses, 1995-08, Vol.45 (2), p.125-128 |
| issn | 0306-9877 1532-2777 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Arteriosclerosis - epidemiology Arteriosclerosis - metabolism Arteriosclerosis - physiopathology Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cholesterol, LDL - metabolism Cyanates - metabolism Humans Kidney Failure, Chronic - metabolism Kidney Failure, Chronic - physiopathology Medical sciences Models, Biological Oxidation-Reduction Risk Factors |
| title | Carbamylation of proteins and atherogenesis in renal failure |
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