Functional and biochemical evidence for altered serotonergic function in the Fawn-Hooded rat strain
Administration of various doses of DOI (a 5-HT 2A/5-HT 2C agonist) produced hyperthermia that was significantly less in the FH rat strain relative to the Wiatar rat strain. Similarly, administration of various doses of ipsapirone (a 5-HT 1A agonist) produced hypothermia that was significantly less i...
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| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 1994-11, Vol.49 (3), p.615-620 |
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| creator | Aulakh, C.S. Tolliver, T. Wozniak, K.M. Hill, J.L. Murphy, D.L. |
| description | Administration of various doses of DOI (a 5-HT
2A/5-HT
2C agonist) produced hyperthermia that was significantly less in the FH rat strain relative to the Wiatar rat strain. Similarly, administration of various doses of ipsapirone (a 5-HT
1A agonist) produced hypothermia that was significantly less in the FH rat strain relative to the Wistar rat strain. Furthermore, m-CPP (a 5-HT agonist)-induced increases in growth hormone levels were also significantly less in the FH rat strain relative to the Wistar rat strain. There was no significant difference in the levels of either 5-HT or 5-HIAA between the two rat strains in the frontal cortex, hippocampus, hypothalamus, and striatum. In the brain stem, however, both 5-HT and 5-HIAA levels were significantly lower in the FH rat strain relative to the Wistar rat strain. On the other hand, 5-HT turnover rate was significantly higher in the hypothalamus and striatum and significantly lower in the hippocampus in the FH rat strain relative to the Wistar rat strain. These findings provide further evidence for altered serotonergic function in the FH rat strain and, in addition, suggest that the FH rat strain may prove to be a useful genetic model for some neuropsychiatric disorders with possible abnormalities in serotonergic function such as depression, obsessive-compulsive disorder, and the eating disorders. |
| doi_str_mv | 10.1016/0091-3057(94)90077-9 |
| format | Article |
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2A/5-HT
2C agonist) produced hyperthermia that was significantly less in the FH rat strain relative to the Wiatar rat strain. Similarly, administration of various doses of ipsapirone (a 5-HT
1A agonist) produced hypothermia that was significantly less in the FH rat strain relative to the Wistar rat strain. Furthermore, m-CPP (a 5-HT agonist)-induced increases in growth hormone levels were also significantly less in the FH rat strain relative to the Wistar rat strain. There was no significant difference in the levels of either 5-HT or 5-HIAA between the two rat strains in the frontal cortex, hippocampus, hypothalamus, and striatum. In the brain stem, however, both 5-HT and 5-HIAA levels were significantly lower in the FH rat strain relative to the Wistar rat strain. On the other hand, 5-HT turnover rate was significantly higher in the hypothalamus and striatum and significantly lower in the hippocampus in the FH rat strain relative to the Wistar rat strain. These findings provide further evidence for altered serotonergic function in the FH rat strain and, in addition, suggest that the FH rat strain may prove to be a useful genetic model for some neuropsychiatric disorders with possible abnormalities in serotonergic function such as depression, obsessive-compulsive disorder, and the eating disorders.</description><identifier>ISSN: 0091-3057</identifier><identifier>EISSN: 1873-5177</identifier><identifier>DOI: 10.1016/0091-3057(94)90077-9</identifier><identifier>PMID: 7532310</identifier><identifier>CODEN: PBBHAU</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Amphetamines - pharmacology ; Animals ; Biological and medical sciences ; Body Temperature - drug effects ; Brain Chemistry - drug effects ; Brain Chemistry - physiology ; Depression, Subsensitive ; Growth Hormone - blood ; Hematologic and hematopoietic diseases ; Hydroxyindoleacetic Acid - metabolism ; m-CPP, DOI, Ipsapirone, Rectal temperature, Growth hormone, Genetic model ; Male ; Medical sciences ; Piperazines - pharmacology ; Platelet diseases and coagulopathies ; Pyrimidines - pharmacology ; Rats ; Rats, Inbred Strains ; Rats, Wistar ; Serotonin - metabolism ; Serotonin - physiology ; Serotonin Receptor Agonists - pharmacology ; Species Specificity</subject><ispartof>Pharmacology, biochemistry and behavior, 1994-11, Vol.49 (3), p.615-620</ispartof><rights>1994</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-f4191f76989e18a373dc9c83bf3c22c215a3ea7fa1835530ecbd8c437cef306c3</citedby><cites>FETCH-LOGICAL-c417t-f4191f76989e18a373dc9c83bf3c22c215a3ea7fa1835530ecbd8c437cef306c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0091-3057(94)90077-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3317580$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7532310$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aulakh, C.S.</creatorcontrib><creatorcontrib>Tolliver, T.</creatorcontrib><creatorcontrib>Wozniak, K.M.</creatorcontrib><creatorcontrib>Hill, J.L.</creatorcontrib><creatorcontrib>Murphy, D.L.</creatorcontrib><title>Functional and biochemical evidence for altered serotonergic function in the Fawn-Hooded rat strain</title><title>Pharmacology, biochemistry and behavior</title><addtitle>Pharmacol Biochem Behav</addtitle><description>Administration of various doses of DOI (a 5-HT
2A/5-HT
2C agonist) produced hyperthermia that was significantly less in the FH rat strain relative to the Wiatar rat strain. Similarly, administration of various doses of ipsapirone (a 5-HT
1A agonist) produced hypothermia that was significantly less in the FH rat strain relative to the Wistar rat strain. Furthermore, m-CPP (a 5-HT agonist)-induced increases in growth hormone levels were also significantly less in the FH rat strain relative to the Wistar rat strain. There was no significant difference in the levels of either 5-HT or 5-HIAA between the two rat strains in the frontal cortex, hippocampus, hypothalamus, and striatum. In the brain stem, however, both 5-HT and 5-HIAA levels were significantly lower in the FH rat strain relative to the Wistar rat strain. On the other hand, 5-HT turnover rate was significantly higher in the hypothalamus and striatum and significantly lower in the hippocampus in the FH rat strain relative to the Wistar rat strain. These findings provide further evidence for altered serotonergic function in the FH rat strain and, in addition, suggest that the FH rat strain may prove to be a useful genetic model for some neuropsychiatric disorders with possible abnormalities in serotonergic function such as depression, obsessive-compulsive disorder, and the eating disorders.</description><subject>Amphetamines - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body Temperature - drug effects</subject><subject>Brain Chemistry - drug effects</subject><subject>Brain Chemistry - physiology</subject><subject>Depression, Subsensitive</subject><subject>Growth Hormone - blood</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hydroxyindoleacetic Acid - metabolism</subject><subject>m-CPP, DOI, Ipsapirone, Rectal temperature, Growth hormone, Genetic model</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Piperazines - pharmacology</subject><subject>Platelet diseases and coagulopathies</subject><subject>Pyrimidines - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Rats, Wistar</subject><subject>Serotonin - metabolism</subject><subject>Serotonin - physiology</subject><subject>Serotonin Receptor Agonists - pharmacology</subject><subject>Species Specificity</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcGKFDEQhoMo6-zoGyjkIKKH1qTT3dW5CLI4u8KCFz2HTKXiRnqSNcms-PZ2O80c9RSK-v4ifD9jL6R4J4Uc3guhZaNED29091YLAdDoR2wjR1BNLwEes80ZecouS_khhOjaAS7YBfSqVVJsGO6OEWtI0U7cRsf3IeEdHQLOMz0ERxGJ-5S5nSplcrxQTjVFyt8Dcr-GeYi83hHf2V-xuUnJzWC2lZeabYjP2BNvp0LP13fLvu0-fb26aW6_XH---njbYCehNr6TWnoY9KhJjlaBcqhxVHuvsG2xlb1VZMFbOaq-V4Jw70bsFCB5JQZUW_b6dPc-p59HKtUcQkGaJhspHYsBANW3Qv4XlMMwCpgNbVl3AjGnUjJ5c5_DwebfRgqzlGAWw2YxbHRn_pZg9Bx7ud4_7g_kzqHV-rx_te5tmUX7bCOGcsaUktCPC_bhhNEs7SFQNgXDUogLmbAal8K___EHEiKjQg</recordid><startdate>19941101</startdate><enddate>19941101</enddate><creator>Aulakh, C.S.</creator><creator>Tolliver, T.</creator><creator>Wozniak, K.M.</creator><creator>Hill, J.L.</creator><creator>Murphy, D.L.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19941101</creationdate><title>Functional and biochemical evidence for altered serotonergic function in the Fawn-Hooded rat strain</title><author>Aulakh, C.S. ; Tolliver, T. ; Wozniak, K.M. ; Hill, J.L. ; Murphy, D.L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-f4191f76989e18a373dc9c83bf3c22c215a3ea7fa1835530ecbd8c437cef306c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Amphetamines - pharmacology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Body Temperature - drug effects</topic><topic>Brain Chemistry - drug effects</topic><topic>Brain Chemistry - physiology</topic><topic>Depression, Subsensitive</topic><topic>Growth Hormone - blood</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hydroxyindoleacetic Acid - metabolism</topic><topic>m-CPP, DOI, Ipsapirone, Rectal temperature, Growth hormone, Genetic model</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Piperazines - pharmacology</topic><topic>Platelet diseases and coagulopathies</topic><topic>Pyrimidines - pharmacology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Rats, Wistar</topic><topic>Serotonin - metabolism</topic><topic>Serotonin - physiology</topic><topic>Serotonin Receptor Agonists - pharmacology</topic><topic>Species Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aulakh, C.S.</creatorcontrib><creatorcontrib>Tolliver, T.</creatorcontrib><creatorcontrib>Wozniak, K.M.</creatorcontrib><creatorcontrib>Hill, J.L.</creatorcontrib><creatorcontrib>Murphy, D.L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aulakh, C.S.</au><au>Tolliver, T.</au><au>Wozniak, K.M.</au><au>Hill, J.L.</au><au>Murphy, D.L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functional and biochemical evidence for altered serotonergic function in the Fawn-Hooded rat strain</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>1994-11-01</date><risdate>1994</risdate><volume>49</volume><issue>3</issue><spage>615</spage><epage>620</epage><pages>615-620</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><coden>PBBHAU</coden><abstract>Administration of various doses of DOI (a 5-HT
2A/5-HT
2C agonist) produced hyperthermia that was significantly less in the FH rat strain relative to the Wiatar rat strain. Similarly, administration of various doses of ipsapirone (a 5-HT
1A agonist) produced hypothermia that was significantly less in the FH rat strain relative to the Wistar rat strain. Furthermore, m-CPP (a 5-HT agonist)-induced increases in growth hormone levels were also significantly less in the FH rat strain relative to the Wistar rat strain. There was no significant difference in the levels of either 5-HT or 5-HIAA between the two rat strains in the frontal cortex, hippocampus, hypothalamus, and striatum. In the brain stem, however, both 5-HT and 5-HIAA levels were significantly lower in the FH rat strain relative to the Wistar rat strain. On the other hand, 5-HT turnover rate was significantly higher in the hypothalamus and striatum and significantly lower in the hippocampus in the FH rat strain relative to the Wistar rat strain. These findings provide further evidence for altered serotonergic function in the FH rat strain and, in addition, suggest that the FH rat strain may prove to be a useful genetic model for some neuropsychiatric disorders with possible abnormalities in serotonergic function such as depression, obsessive-compulsive disorder, and the eating disorders.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>7532310</pmid><doi>10.1016/0091-3057(94)90077-9</doi><tpages>6</tpages></addata></record> |
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| ispartof | Pharmacology, biochemistry and behavior, 1994-11, Vol.49 (3), p.615-620 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Amphetamines - pharmacology Animals Biological and medical sciences Body Temperature - drug effects Brain Chemistry - drug effects Brain Chemistry - physiology Depression, Subsensitive Growth Hormone - blood Hematologic and hematopoietic diseases Hydroxyindoleacetic Acid - metabolism m-CPP, DOI, Ipsapirone, Rectal temperature, Growth hormone, Genetic model Male Medical sciences Piperazines - pharmacology Platelet diseases and coagulopathies Pyrimidines - pharmacology Rats Rats, Inbred Strains Rats, Wistar Serotonin - metabolism Serotonin - physiology Serotonin Receptor Agonists - pharmacology Species Specificity |
| title | Functional and biochemical evidence for altered serotonergic function in the Fawn-Hooded rat strain |
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