Basal forebrain control of cortical blood flow and tissue gases in conscious aged rats

Cholinergic projections from the basal forebrain are capable of influencing local cortical blood flow (CoBF). The effect of age on this influence was investigated by measuring CoBF and tissue gas partial pressures (PtO 2, PtCO 2) by mass spectrometry in conscious young adult (2–4 months) and aged (2...

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Veröffentlicht in:	Brain research 1994-10, Vol.662 (1), p.155-164
Hauptverfasser:	Sercombe, R., Lacombe, P., Springhetti, V., MacKenzie, E.T., Seylaz, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - metabolism Alzheimer's disease, Fischer 344 rat Animals Basal forebrain Biological and medical sciences Blood Gas Analysis Blood Pressure - drug effects Carbon Dioxide - metabolism Cerebral blood flow regulation Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Cerebral Cortex - blood supply Cerebral Cortex - metabolism Cerebral Cortex - physiology Cerebrovascular Circulation - drug effects Cerebrovascular Circulation - physiology Cortical blood flow Cortical PCO 2 Cortical PO 2 Electric Stimulation Fundamental and applied biological sciences. Psychology Gases - metabolism Helium clearance Intrinsic cholinergic innervation Male Oxygen Consumption - drug effects Physostigmine Physostigmine - pharmacology Prosencephalon - physiology Rats Rats, Inbred F344 Substantia innominata Substantia Innominata - drug effects Substantia Innominata - physiology Vertebrates: nervous system and sense organs
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