Basal forebrain control of cortical blood flow and tissue gases in conscious aged rats
Cholinergic projections from the basal forebrain are capable of influencing local cortical blood flow (CoBF). The effect of age on this influence was investigated by measuring CoBF and tissue gas partial pressures (PtO 2, PtCO 2) by mass spectrometry in conscious young adult (2–4 months) and aged (2...
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| Veröffentlicht in: | Brain research 1994-10, Vol.662 (1), p.155-164 |
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| creator | Sercombe, R. Lacombe, P. Springhetti, V. MacKenzie, E.T. Seylaz, J. |
| description | Cholinergic projections from the basal forebrain are capable of influencing local cortical blood flow (CoBF). The effect of age on this influence was investigated by measuring CoBF and tissue gas partial pressures (PtO
2, PtCO
2) by mass spectrometry in conscious young adult (2–4 months) and aged (22–28 months) Fischer 344 rats. Electrical stimulation (50 μA) of the substantia innominata (SI) increased frontal (+100.9%) and parietal (+28.4%) CoBF in young rats, but the effects were less in aged rats (frontal, +48.6%,
P < 0.05; parietal, +18.9%, difference N.S.). Frontal PtO
2 was increased in young but not aged rats (
P < 0.01.). During standard hypercapnia, changes in CoBF, PtO
2 and PtCO
2 did not differ between young and aged rats. Under physostigmine infusion (0.15 mg/kg/h, i.v.), the CoBF increases to SI stimulation were approximately doubled in both cortices, in young and aged rats, and PtO
2 increases were also significantly greater. However, frontal PtO
2 increases were significantly smaller in aged (+7.6%) than in young (32.7%) rats, as were frontal PtCO
2 reductions. We conclude: (i) the influence of the SI on frontal CoBF and PtO
2 is substantially reduced with age; (ii) although physostigmine treatment potentiates this influence in both groups, the beneficial effects are relatively limited for aged rats. |
| doi_str_mv | 10.1016/0006-8993(94)90808-7 |
| format | Article |
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2, PtCO
2) by mass spectrometry in conscious young adult (2–4 months) and aged (22–28 months) Fischer 344 rats. Electrical stimulation (50 μA) of the substantia innominata (SI) increased frontal (+100.9%) and parietal (+28.4%) CoBF in young rats, but the effects were less in aged rats (frontal, +48.6%,
P < 0.05; parietal, +18.9%, difference N.S.). Frontal PtO
2 was increased in young but not aged rats (
P < 0.01.). During standard hypercapnia, changes in CoBF, PtO
2 and PtCO
2 did not differ between young and aged rats. Under physostigmine infusion (0.15 mg/kg/h, i.v.), the CoBF increases to SI stimulation were approximately doubled in both cortices, in young and aged rats, and PtO
2 increases were also significantly greater. However, frontal PtO
2 increases were significantly smaller in aged (+7.6%) than in young (32.7%) rats, as were frontal PtCO
2 reductions. We conclude: (i) the influence of the SI on frontal CoBF and PtO
2 is substantially reduced with age; (ii) although physostigmine treatment potentiates this influence in both groups, the beneficial effects are relatively limited for aged rats.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(94)90808-7</identifier><identifier>PMID: 7859069</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Aging ; Aging - metabolism ; Alzheimer's disease, Fischer 344 rat ; Animals ; Basal forebrain ; Biological and medical sciences ; Blood Gas Analysis ; Blood Pressure - drug effects ; Carbon Dioxide - metabolism ; Cerebral blood flow regulation ; Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges ; Cerebral Cortex - blood supply ; Cerebral Cortex - metabolism ; Cerebral Cortex - physiology ; Cerebrovascular Circulation - drug effects ; Cerebrovascular Circulation - physiology ; Cortical blood flow ; Cortical PCO 2 ; Cortical PO 2 ; Electric Stimulation ; Fundamental and applied biological sciences. Psychology ; Gases - metabolism ; Helium clearance ; Intrinsic cholinergic innervation ; Male ; Oxygen Consumption - drug effects ; Physostigmine ; Physostigmine - pharmacology ; Prosencephalon - physiology ; Rats ; Rats, Inbred F344 ; Substantia innominata ; Substantia Innominata - drug effects ; Substantia Innominata - physiology ; Vertebrates: nervous system and sense organs</subject><ispartof>Brain research, 1994-10, Vol.662 (1), p.155-164</ispartof><rights>1994</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-6a3a6933bb74df938572d908a7013073d582f529673d8c6d74934eb5bf561ba73</citedby><cites>FETCH-LOGICAL-c417t-6a3a6933bb74df938572d908a7013073d582f529673d8c6d74934eb5bf561ba73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-8993(94)90808-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3298210$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7859069$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sercombe, R.</creatorcontrib><creatorcontrib>Lacombe, P.</creatorcontrib><creatorcontrib>Springhetti, V.</creatorcontrib><creatorcontrib>MacKenzie, E.T.</creatorcontrib><creatorcontrib>Seylaz, J.</creatorcontrib><title>Basal forebrain control of cortical blood flow and tissue gases in conscious aged rats</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Cholinergic projections from the basal forebrain are capable of influencing local cortical blood flow (CoBF). The effect of age on this influence was investigated by measuring CoBF and tissue gas partial pressures (PtO
2, PtCO
2) by mass spectrometry in conscious young adult (2–4 months) and aged (22–28 months) Fischer 344 rats. Electrical stimulation (50 μA) of the substantia innominata (SI) increased frontal (+100.9%) and parietal (+28.4%) CoBF in young rats, but the effects were less in aged rats (frontal, +48.6%,
P < 0.05; parietal, +18.9%, difference N.S.). Frontal PtO
2 was increased in young but not aged rats (
P < 0.01.). During standard hypercapnia, changes in CoBF, PtO
2 and PtCO
2 did not differ between young and aged rats. Under physostigmine infusion (0.15 mg/kg/h, i.v.), the CoBF increases to SI stimulation were approximately doubled in both cortices, in young and aged rats, and PtO
2 increases were also significantly greater. However, frontal PtO
2 increases were significantly smaller in aged (+7.6%) than in young (32.7%) rats, as were frontal PtCO
2 reductions. We conclude: (i) the influence of the SI on frontal CoBF and PtO
2 is substantially reduced with age; (ii) although physostigmine treatment potentiates this influence in both groups, the beneficial effects are relatively limited for aged rats.</description><subject>Aging</subject><subject>Aging - metabolism</subject><subject>Alzheimer's disease, Fischer 344 rat</subject><subject>Animals</subject><subject>Basal forebrain</subject><subject>Biological and medical sciences</subject><subject>Blood Gas Analysis</subject><subject>Blood Pressure - drug effects</subject><subject>Carbon Dioxide - metabolism</subject><subject>Cerebral blood flow regulation</subject><subject>Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges</subject><subject>Cerebral Cortex - blood supply</subject><subject>Cerebral Cortex - metabolism</subject><subject>Cerebral Cortex - physiology</subject><subject>Cerebrovascular Circulation - drug effects</subject><subject>Cerebrovascular Circulation - physiology</subject><subject>Cortical blood flow</subject><subject>Cortical PCO 2</subject><subject>Cortical PO 2</subject><subject>Electric Stimulation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gases - metabolism</subject><subject>Helium clearance</subject><subject>Intrinsic cholinergic innervation</subject><subject>Male</subject><subject>Oxygen Consumption - drug effects</subject><subject>Physostigmine</subject><subject>Physostigmine - pharmacology</subject><subject>Prosencephalon - physiology</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Substantia innominata</subject><subject>Substantia Innominata - drug effects</subject><subject>Substantia Innominata - physiology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1rGzEQhkVpcJy0_yABHUpIDttKK60-LoHE5KNgyKXtVWj1YRTWq1SzTum_j1wbH5uTRswzwzsPQmeUfKWEim-EENEordml5leaKKIa-QHNqZJtI1pOPqL5ATlGJwDP9cuYJjM0k6rTROg5-nVrwQ445hL6YtOIXR6nkgecYy3LlFzt9kPOHsch_8F29HhKAJuAVxYC4N0IuJQ3gO0qeFzsBJ_QUbQDhM_79xT9vL_7sXhslk8P3xc3y8ZxKqdGWGaFZqzvJfdRM9XJ1tdTrCSUEcl8p9rYtVrUUjnhJdeMh77rYydobyU7RRe7vS8l_94EmMw6gQvDYMdQAxkpJWN16F2Qik4JLtsK8h3oSgYoIZqXkta2_DWUmK13s5VqtlKN5uafd7MNcr7fv-nXwR-G9qJr_8u-b6EqjcWOLsEBY61WLSUVu95hoUp7TaGYajaMLvhUgpuMz-n_Od4ADGKdbQ</recordid><startdate>19941031</startdate><enddate>19941031</enddate><creator>Sercombe, R.</creator><creator>Lacombe, P.</creator><creator>Springhetti, V.</creator><creator>MacKenzie, E.T.</creator><creator>Seylaz, J.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19941031</creationdate><title>Basal forebrain control of cortical blood flow and tissue gases in conscious aged rats</title><author>Sercombe, R. ; Lacombe, P. ; Springhetti, V. ; MacKenzie, E.T. ; Seylaz, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-6a3a6933bb74df938572d908a7013073d582f529673d8c6d74934eb5bf561ba73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Aging</topic><topic>Aging - metabolism</topic><topic>Alzheimer's disease, Fischer 344 rat</topic><topic>Animals</topic><topic>Basal forebrain</topic><topic>Biological and medical sciences</topic><topic>Blood Gas Analysis</topic><topic>Blood Pressure - drug effects</topic><topic>Carbon Dioxide - metabolism</topic><topic>Cerebral blood flow regulation</topic><topic>Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges</topic><topic>Cerebral Cortex - blood supply</topic><topic>Cerebral Cortex - metabolism</topic><topic>Cerebral Cortex - physiology</topic><topic>Cerebrovascular Circulation - drug effects</topic><topic>Cerebrovascular Circulation - physiology</topic><topic>Cortical blood flow</topic><topic>Cortical PCO 2</topic><topic>Cortical PO 2</topic><topic>Electric Stimulation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gases - metabolism</topic><topic>Helium clearance</topic><topic>Intrinsic cholinergic innervation</topic><topic>Male</topic><topic>Oxygen Consumption - drug effects</topic><topic>Physostigmine</topic><topic>Physostigmine - pharmacology</topic><topic>Prosencephalon - physiology</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Substantia innominata</topic><topic>Substantia Innominata - drug effects</topic><topic>Substantia Innominata - physiology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sercombe, R.</creatorcontrib><creatorcontrib>Lacombe, P.</creatorcontrib><creatorcontrib>Springhetti, V.</creatorcontrib><creatorcontrib>MacKenzie, E.T.</creatorcontrib><creatorcontrib>Seylaz, J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sercombe, R.</au><au>Lacombe, P.</au><au>Springhetti, V.</au><au>MacKenzie, E.T.</au><au>Seylaz, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Basal forebrain control of cortical blood flow and tissue gases in conscious aged rats</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1994-10-31</date><risdate>1994</risdate><volume>662</volume><issue>1</issue><spage>155</spage><epage>164</epage><pages>155-164</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Cholinergic projections from the basal forebrain are capable of influencing local cortical blood flow (CoBF). The effect of age on this influence was investigated by measuring CoBF and tissue gas partial pressures (PtO
2, PtCO
2) by mass spectrometry in conscious young adult (2–4 months) and aged (22–28 months) Fischer 344 rats. Electrical stimulation (50 μA) of the substantia innominata (SI) increased frontal (+100.9%) and parietal (+28.4%) CoBF in young rats, but the effects were less in aged rats (frontal, +48.6%,
P < 0.05; parietal, +18.9%, difference N.S.). Frontal PtO
2 was increased in young but not aged rats (
P < 0.01.). During standard hypercapnia, changes in CoBF, PtO
2 and PtCO
2 did not differ between young and aged rats. Under physostigmine infusion (0.15 mg/kg/h, i.v.), the CoBF increases to SI stimulation were approximately doubled in both cortices, in young and aged rats, and PtO
2 increases were also significantly greater. However, frontal PtO
2 increases were significantly smaller in aged (+7.6%) than in young (32.7%) rats, as were frontal PtCO
2 reductions. We conclude: (i) the influence of the SI on frontal CoBF and PtO
2 is substantially reduced with age; (ii) although physostigmine treatment potentiates this influence in both groups, the beneficial effects are relatively limited for aged rats.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>7859069</pmid><doi>10.1016/0006-8993(94)90808-7</doi><tpages>10</tpages></addata></record> |
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| ispartof | Brain research, 1994-10, Vol.662 (1), p.155-164 |
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| subjects | Aging Aging - metabolism Alzheimer's disease, Fischer 344 rat Animals Basal forebrain Biological and medical sciences Blood Gas Analysis Blood Pressure - drug effects Carbon Dioxide - metabolism Cerebral blood flow regulation Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Cerebral Cortex - blood supply Cerebral Cortex - metabolism Cerebral Cortex - physiology Cerebrovascular Circulation - drug effects Cerebrovascular Circulation - physiology Cortical blood flow Cortical PCO 2 Cortical PO 2 Electric Stimulation Fundamental and applied biological sciences. Psychology Gases - metabolism Helium clearance Intrinsic cholinergic innervation Male Oxygen Consumption - drug effects Physostigmine Physostigmine - pharmacology Prosencephalon - physiology Rats Rats, Inbred F344 Substantia innominata Substantia Innominata - drug effects Substantia Innominata - physiology Vertebrates: nervous system and sense organs |
| title | Basal forebrain control of cortical blood flow and tissue gases in conscious aged rats |
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