Sucrase-isomaltase is an independent prognostic marker for colorectal carcinoma
Expression of disaccharidase sucrase-isomaltase (SI) is significantly enhanced during neoplastic transformation of colonic epithelium. Our study was designed to determine whether expression of SI within primary tumors was significantly associated with survival in patients with colorectal carcinoma (...
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| Veröffentlicht in: | Diseases of the colon & rectum 1995-12, Vol.38 (12), p.1257-1264 |
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| container_title | Diseases of the colon & rectum |
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| creator | JESSUP, J. M LAVIN, P. T ANDREWS, C. W LODA, M MERCURIO, A MINSKY, B. D MIES, C CUKOR, B BLEDAY, R STEELE, G. JR |
| description | Expression of disaccharidase sucrase-isomaltase (SI) is significantly enhanced during neoplastic transformation of colonic epithelium. Our study was designed to determine whether expression of SI within primary tumors was significantly associated with survival in patients with colorectal carcinoma (CRC).
SI expression was analyzed by immunohistochemistry in paraffin sections from 182 Stage I to III CRC that had been resected for cure at the New England Deaconess Hospital between 1965 and 1977. Expression was scored as absent or present in 1 to 50 percent or more than 50 percent of tumor cells. Associations were explored among SI expression, other clinical or pathologic variables, and overall survival. The data set is mature, with 91 (56 percent) patients who had died of CRC at a median follow-up of 96 months.
Fifty-five percent of primary CRC expressed SI. When the multivariate Cox analysis was performed, nodal status, T stage, primary site, grade, and SI expression were independent covariates. SI expression was not associated with the expression of other clinicopathologic variables but increased the risk of death from colorectal carcinoma by 1.83-fold.
These results indicate that SI is a prognostic marker for CRC that is independent of stage-related variables in patients who have undergone potentially curative resections. |
| doi_str_mv | 10.1007/bf02049149 |
| format | Article |
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SI expression was analyzed by immunohistochemistry in paraffin sections from 182 Stage I to III CRC that had been resected for cure at the New England Deaconess Hospital between 1965 and 1977. Expression was scored as absent or present in 1 to 50 percent or more than 50 percent of tumor cells. Associations were explored among SI expression, other clinical or pathologic variables, and overall survival. The data set is mature, with 91 (56 percent) patients who had died of CRC at a median follow-up of 96 months.
Fifty-five percent of primary CRC expressed SI. When the multivariate Cox analysis was performed, nodal status, T stage, primary site, grade, and SI expression were independent covariates. SI expression was not associated with the expression of other clinicopathologic variables but increased the risk of death from colorectal carcinoma by 1.83-fold.
These results indicate that SI is a prognostic marker for CRC that is independent of stage-related variables in patients who have undergone potentially curative resections.</description><identifier>ISSN: 0012-3706</identifier><identifier>EISSN: 1530-0358</identifier><identifier>DOI: 10.1007/bf02049149</identifier><identifier>PMID: 7497836</identifier><identifier>CODEN: DICRAG</identifier><language>eng</language><publisher>Secaucus, NJ: Springer</publisher><subject>Aged ; Biological and medical sciences ; Biomarkers, Tumor - analysis ; Biomarkers, Tumor - genetics ; Carcinoma - enzymology ; Carcinoma - genetics ; Carcinoma - pathology ; Carcinoma - surgery ; Cell Transformation, Neoplastic - genetics ; Cell Transformation, Neoplastic - metabolism ; Cell Transformation, Neoplastic - pathology ; Colon - enzymology ; Colon - pathology ; Colonic Neoplasms - enzymology ; Colonic Neoplasms - genetics ; Colonic Neoplasms - pathology ; Colonic Neoplasms - surgery ; Female ; Follow-Up Studies ; Gastroenterology. Liver. Pancreas. Abdomen ; Gene Expression Regulation, Enzymologic ; Gene Expression Regulation, Neoplastic ; Humans ; Immunohistochemistry ; Male ; Medical sciences ; Multivariate Analysis ; Neoplasm Staging ; Oligo-1,6-Glucosidase - analysis ; Oligo-1,6-Glucosidase - genetics ; Prognosis ; Proportional Hazards Models ; Rectal Neoplasms - enzymology ; Rectal Neoplasms - genetics ; Rectal Neoplasms - pathology ; Rectal Neoplasms - surgery ; Retrospective Studies ; Risk Factors ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Sucrase - analysis ; Sucrase - genetics ; Survival Rate ; Tumors</subject><ispartof>Diseases of the colon & rectum, 1995-12, Vol.38 (12), p.1257-1264</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c340t-3e715283df4d4776e7347f4232d621e55ac60d46860d6134cf2abafd288a82133</citedby><cites>FETCH-LOGICAL-c340t-3e715283df4d4776e7347f4232d621e55ac60d46860d6134cf2abafd288a82133</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,780,784,789,790,23930,23931,25140,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2934711$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7497836$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>JESSUP, J. M</creatorcontrib><creatorcontrib>LAVIN, P. T</creatorcontrib><creatorcontrib>ANDREWS, C. W</creatorcontrib><creatorcontrib>LODA, M</creatorcontrib><creatorcontrib>MERCURIO, A</creatorcontrib><creatorcontrib>MINSKY, B. D</creatorcontrib><creatorcontrib>MIES, C</creatorcontrib><creatorcontrib>CUKOR, B</creatorcontrib><creatorcontrib>BLEDAY, R</creatorcontrib><creatorcontrib>STEELE, G. JR</creatorcontrib><title>Sucrase-isomaltase is an independent prognostic marker for colorectal carcinoma</title><title>Diseases of the colon & rectum</title><addtitle>Dis Colon Rectum</addtitle><description>Expression of disaccharidase sucrase-isomaltase (SI) is significantly enhanced during neoplastic transformation of colonic epithelium. Our study was designed to determine whether expression of SI within primary tumors was significantly associated with survival in patients with colorectal carcinoma (CRC).
SI expression was analyzed by immunohistochemistry in paraffin sections from 182 Stage I to III CRC that had been resected for cure at the New England Deaconess Hospital between 1965 and 1977. Expression was scored as absent or present in 1 to 50 percent or more than 50 percent of tumor cells. Associations were explored among SI expression, other clinical or pathologic variables, and overall survival. The data set is mature, with 91 (56 percent) patients who had died of CRC at a median follow-up of 96 months.
Fifty-five percent of primary CRC expressed SI. When the multivariate Cox analysis was performed, nodal status, T stage, primary site, grade, and SI expression were independent covariates. SI expression was not associated with the expression of other clinicopathologic variables but increased the risk of death from colorectal carcinoma by 1.83-fold.
These results indicate that SI is a prognostic marker for CRC that is independent of stage-related variables in patients who have undergone potentially curative resections.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Carcinoma - enzymology</subject><subject>Carcinoma - genetics</subject><subject>Carcinoma - pathology</subject><subject>Carcinoma - surgery</subject><subject>Cell Transformation, Neoplastic - genetics</subject><subject>Cell Transformation, Neoplastic - metabolism</subject><subject>Cell Transformation, Neoplastic - pathology</subject><subject>Colon - enzymology</subject><subject>Colon - pathology</subject><subject>Colonic Neoplasms - enzymology</subject><subject>Colonic Neoplasms - genetics</subject><subject>Colonic Neoplasms - pathology</subject><subject>Colonic Neoplasms - surgery</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Gene Expression Regulation, Enzymologic</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Multivariate Analysis</subject><subject>Neoplasm Staging</subject><subject>Oligo-1,6-Glucosidase - analysis</subject><subject>Oligo-1,6-Glucosidase - genetics</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Rectal Neoplasms - enzymology</subject><subject>Rectal Neoplasms - genetics</subject><subject>Rectal Neoplasms - pathology</subject><subject>Rectal Neoplasms - surgery</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Sucrase - analysis</subject><subject>Sucrase - genetics</subject><subject>Survival Rate</subject><subject>Tumors</subject><issn>0012-3706</issn><issn>1530-0358</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kDtPwzAUhS0EKqWwsCN5QAxIAb9iJyNUFJAqdQDm6NYPZEjiYicD_x6jBpb70P10dM9B6JySG0qIut06woioqagP0JyWnBSEl9UhmhNCWcEVkcfoJKWPvGZQzdBMiVpVXM7R5mXUEZItfAodtEMesU8Yeux7Y3c2l37Auxje-5AGr3EH8dNG7ELEOrQhWj1AizVE7fuscIqOHLTJnk19gd5WD6_Lp2K9eXxe3q0LzQUZCm4VLVnFjRNGKCWt4kI5wTgzklFblqAlMUJWuUrKhXYMtuAMqyqoGOV8ga72uvm1r9Gmoel80rZtobdhTI1SiudMaAav96COIaVoXbOLPpv4bihpftNr7ld_6WX4YlIdt501_-gUV75fTndIGloXodc-_WOszi4o5T-agXYp</recordid><startdate>19951201</startdate><enddate>19951201</enddate><creator>JESSUP, J. M</creator><creator>LAVIN, P. T</creator><creator>ANDREWS, C. W</creator><creator>LODA, M</creator><creator>MERCURIO, A</creator><creator>MINSKY, B. 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JR</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c340t-3e715283df4d4776e7347f4232d621e55ac60d46860d6134cf2abafd288a82133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Carcinoma - enzymology</topic><topic>Carcinoma - genetics</topic><topic>Carcinoma - pathology</topic><topic>Carcinoma - surgery</topic><topic>Cell Transformation, Neoplastic - genetics</topic><topic>Cell Transformation, Neoplastic - metabolism</topic><topic>Cell Transformation, Neoplastic - pathology</topic><topic>Colon - enzymology</topic><topic>Colon - pathology</topic><topic>Colonic Neoplasms - enzymology</topic><topic>Colonic Neoplasms - genetics</topic><topic>Colonic Neoplasms - pathology</topic><topic>Colonic Neoplasms - surgery</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Gene Expression Regulation, Enzymologic</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Multivariate Analysis</topic><topic>Neoplasm Staging</topic><topic>Oligo-1,6-Glucosidase - analysis</topic><topic>Oligo-1,6-Glucosidase - genetics</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Rectal Neoplasms - enzymology</topic><topic>Rectal Neoplasms - genetics</topic><topic>Rectal Neoplasms - pathology</topic><topic>Rectal Neoplasms - surgery</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Sucrase - analysis</topic><topic>Sucrase - genetics</topic><topic>Survival Rate</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>JESSUP, J. M</creatorcontrib><creatorcontrib>LAVIN, P. T</creatorcontrib><creatorcontrib>ANDREWS, C. W</creatorcontrib><creatorcontrib>LODA, M</creatorcontrib><creatorcontrib>MERCURIO, A</creatorcontrib><creatorcontrib>MINSKY, B. D</creatorcontrib><creatorcontrib>MIES, C</creatorcontrib><creatorcontrib>CUKOR, B</creatorcontrib><creatorcontrib>BLEDAY, R</creatorcontrib><creatorcontrib>STEELE, G. JR</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diseases of the colon & rectum</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>JESSUP, J. M</au><au>LAVIN, P. T</au><au>ANDREWS, C. W</au><au>LODA, M</au><au>MERCURIO, A</au><au>MINSKY, B. D</au><au>MIES, C</au><au>CUKOR, B</au><au>BLEDAY, R</au><au>STEELE, G. JR</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sucrase-isomaltase is an independent prognostic marker for colorectal carcinoma</atitle><jtitle>Diseases of the colon & rectum</jtitle><addtitle>Dis Colon Rectum</addtitle><date>1995-12-01</date><risdate>1995</risdate><volume>38</volume><issue>12</issue><spage>1257</spage><epage>1264</epage><pages>1257-1264</pages><issn>0012-3706</issn><eissn>1530-0358</eissn><coden>DICRAG</coden><abstract>Expression of disaccharidase sucrase-isomaltase (SI) is significantly enhanced during neoplastic transformation of colonic epithelium. Our study was designed to determine whether expression of SI within primary tumors was significantly associated with survival in patients with colorectal carcinoma (CRC).
SI expression was analyzed by immunohistochemistry in paraffin sections from 182 Stage I to III CRC that had been resected for cure at the New England Deaconess Hospital between 1965 and 1977. Expression was scored as absent or present in 1 to 50 percent or more than 50 percent of tumor cells. Associations were explored among SI expression, other clinical or pathologic variables, and overall survival. The data set is mature, with 91 (56 percent) patients who had died of CRC at a median follow-up of 96 months.
Fifty-five percent of primary CRC expressed SI. When the multivariate Cox analysis was performed, nodal status, T stage, primary site, grade, and SI expression were independent covariates. SI expression was not associated with the expression of other clinicopathologic variables but increased the risk of death from colorectal carcinoma by 1.83-fold.
These results indicate that SI is a prognostic marker for CRC that is independent of stage-related variables in patients who have undergone potentially curative resections.</abstract><cop>Secaucus, NJ</cop><pub>Springer</pub><pmid>7497836</pmid><doi>10.1007/bf02049149</doi><tpages>8</tpages></addata></record> |
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| ispartof | Diseases of the colon & rectum, 1995-12, Vol.38 (12), p.1257-1264 |
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| subjects | Aged Biological and medical sciences Biomarkers, Tumor - analysis Biomarkers, Tumor - genetics Carcinoma - enzymology Carcinoma - genetics Carcinoma - pathology Carcinoma - surgery Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology Colon - enzymology Colon - pathology Colonic Neoplasms - enzymology Colonic Neoplasms - genetics Colonic Neoplasms - pathology Colonic Neoplasms - surgery Female Follow-Up Studies Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Humans Immunohistochemistry Male Medical sciences Multivariate Analysis Neoplasm Staging Oligo-1,6-Glucosidase - analysis Oligo-1,6-Glucosidase - genetics Prognosis Proportional Hazards Models Rectal Neoplasms - enzymology Rectal Neoplasms - genetics Rectal Neoplasms - pathology Rectal Neoplasms - surgery Retrospective Studies Risk Factors Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Sucrase - analysis Sucrase - genetics Survival Rate Tumors |
| title | Sucrase-isomaltase is an independent prognostic marker for colorectal carcinoma |
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