CEPACIDINE A, A NOVEL ANTIFUNGAL ANTIBIOTIC PRODUCED BY Pseudomonas cepacia: I. TAXONOMY, PRODUCTION, ISOLATION AND BIOLOGICAL ACTIVITY
Cepacidine A is a potent antifungal antibiotic produced by Pseudomonas cepacia AF 2001. The compound was isolated from the fermentation broth with 1 vol isopropyl alcohol, followed by the collection of the precipitation formed upon concentration of the extract. Purification was effected by chromatog...
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| Veröffentlicht in: | Journal of antibiotics 1994/12/25, Vol.47(12), pp.1402-1405 |
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| container_title | Journal of antibiotics |
| container_volume | 47 |
| creator | LEE, CHUL-HOON KIM, SUNGHO HYUN, BONGCHUL SUH, JUNG-WOO YON, CHANGSUEK KIM, CHANGONE LIM, YOONGHO KIM, CHOONGSUP |
| description | Cepacidine A is a potent antifungal antibiotic produced by Pseudomonas cepacia AF 2001. The compound was isolated from the fermentation broth with 1 vol isopropyl alcohol, followed by the collection of the precipitation formed upon concentration of the extract. Purification was effected by chromatography on Diaion HP-20, alumina and reversed phase C18 followed by TLC on silica gel. These techniques afforded the two closely related compounds, cepacidine A1 and cepacidine A2. A mixture of these two compounds called cepacidine A, showed high in vitro antifungal activity against the various animal and plant pathogenic fungi. The activity was diminished by the presence of serum. No antibacterial activity was demonstrable. |
| doi_str_mv | 10.7164/antibiotics.47.1402 |
| format | Article |
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TAXONOMY, PRODUCTION, ISOLATION AND BIOLOGICAL ACTIVITY</title><source>MEDLINE</source><source>J-STAGE</source><creator>LEE, CHUL-HOON ; KIM, SUNGHO ; HYUN, BONGCHUL ; SUH, JUNG-WOO ; YON, CHANGSUEK ; KIM, CHANGONE ; LIM, YOONGHO ; KIM, CHOONGSUP</creator><creatorcontrib>LEE, CHUL-HOON ; KIM, SUNGHO ; HYUN, BONGCHUL ; SUH, JUNG-WOO ; YON, CHANGSUEK ; KIM, CHANGONE ; LIM, YOONGHO ; KIM, CHOONGSUP</creatorcontrib><description>Cepacidine A is a potent antifungal antibiotic produced by Pseudomonas cepacia AF 2001. The compound was isolated from the fermentation broth with 1 vol isopropyl alcohol, followed by the collection of the precipitation formed upon concentration of the extract. Purification was effected by chromatography on Diaion HP-20, alumina and reversed phase C18 followed by TLC on silica gel. These techniques afforded the two closely related compounds, cepacidine A1 and cepacidine A2. A mixture of these two compounds called cepacidine A, showed high in vitro antifungal activity against the various animal and plant pathogenic fungi. The activity was diminished by the presence of serum. No antibacterial activity was demonstrable.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.7164/antibiotics.47.1402</identifier><identifier>PMID: 7531193</identifier><identifier>CODEN: JANTAJ</identifier><language>eng</language><publisher>Tokyo: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</publisher><subject>Anti-Bacterial Agents - biosynthesis ; Anti-Bacterial Agents - isolation & purification ; Anti-Bacterial Agents - pharmacology ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antifungal agents ; Antifungal Agents - biosynthesis ; Antifungal Agents - isolation & purification ; Antifungal Agents - pharmacology ; Biological and medical sciences ; Blood ; Burkholderia cepacia - classification ; Burkholderia cepacia - metabolism ; Chromatography, High Pressure Liquid ; Chromatography, Ion Exchange ; Chromatography, Thin Layer ; Humans ; Medical sciences ; Peptides ; Pharmacology. Drug treatments ; Pseudomonas cepacia</subject><ispartof>The Journal of Antibiotics, 1994/12/25, Vol.47(12), pp.1402-1405</ispartof><rights>Japan Antibiotics Research Association</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4932-9f99a2ef375c8a211eae316b1fd89b4be2e5c792f3fd5562b35fc2dbb8ec616b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,1877,4010,27904,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3413969$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7531193$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LEE, CHUL-HOON</creatorcontrib><creatorcontrib>KIM, SUNGHO</creatorcontrib><creatorcontrib>HYUN, BONGCHUL</creatorcontrib><creatorcontrib>SUH, JUNG-WOO</creatorcontrib><creatorcontrib>YON, CHANGSUEK</creatorcontrib><creatorcontrib>KIM, CHANGONE</creatorcontrib><creatorcontrib>LIM, YOONGHO</creatorcontrib><creatorcontrib>KIM, CHOONGSUP</creatorcontrib><title>CEPACIDINE A, A NOVEL ANTIFUNGAL ANTIBIOTIC PRODUCED BY Pseudomonas cepacia: I. TAXONOMY, PRODUCTION, ISOLATION AND BIOLOGICAL ACTIVITY</title><title>Journal of antibiotics</title><addtitle>J. Antibiot.</addtitle><description>Cepacidine A is a potent antifungal antibiotic produced by Pseudomonas cepacia AF 2001. The compound was isolated from the fermentation broth with 1 vol isopropyl alcohol, followed by the collection of the precipitation formed upon concentration of the extract. Purification was effected by chromatography on Diaion HP-20, alumina and reversed phase C18 followed by TLC on silica gel. These techniques afforded the two closely related compounds, cepacidine A1 and cepacidine A2. A mixture of these two compounds called cepacidine A, showed high in vitro antifungal activity against the various animal and plant pathogenic fungi. The activity was diminished by the presence of serum. No antibacterial activity was demonstrable.</description><subject>Anti-Bacterial Agents - biosynthesis</subject><subject>Anti-Bacterial Agents - isolation & purification</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antifungal agents</subject><subject>Antifungal Agents - biosynthesis</subject><subject>Antifungal Agents - isolation & purification</subject><subject>Antifungal Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Burkholderia cepacia - classification</subject><subject>Burkholderia cepacia - metabolism</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Chromatography, Ion Exchange</subject><subject>Chromatography, Thin Layer</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Peptides</subject><subject>Pharmacology. Drug treatments</subject><subject>Pseudomonas cepacia</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEGP0zAQha0VaCnL_gKElAPiRIrHTmL7mE2zS0SVVqhdaU-W44whqzTpxu2Bf09Ko2pvXMYjvW_mjR8hH4HOBSTRN9MdmqrpD43180jMIaLsisxASgghStQbMqOUQSglo-_Ie--fKeWCC3lNrkXMARSfkR9Zvk6zYlGUeZB-DdKgXD3myyAtN8X9tnxIz-1dsdoUWbD-uVpss3wR3D0Fa4_Hut_1nfGBxb2xjflA3jrTeryd3huyvc832fdwuXoosnQZ2khxFiqnlGHouIitNAwADXJIKnC1VFVUIcPYCsUcd3UcJ6zisbOsriqJNhk5fkO-nPfuh_7liP6gd4232Lamw_7otRCCU5XI_4KQCC6pikeQn0E79N4P6PR-aHZm-KOB6lPW-lXWOhL6lPU49Wlaf6x2WF9mpnBH_fOkG29N6wbT2cZfMB4BV4kasfKMPfuD-YUX3QyjW4uvrWH81T97NtXTHRfQ_jaDxo7_BWT8oQM</recordid><startdate>1994</startdate><enddate>1994</enddate><creator>LEE, CHUL-HOON</creator><creator>KIM, SUNGHO</creator><creator>HYUN, BONGCHUL</creator><creator>SUH, JUNG-WOO</creator><creator>YON, CHANGSUEK</creator><creator>KIM, CHANGONE</creator><creator>LIM, YOONGHO</creator><creator>KIM, CHOONGSUP</creator><general>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</general><general>Japan Antibiotics Research Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>1994</creationdate><title>CEPACIDINE A, A NOVEL ANTIFUNGAL ANTIBIOTIC PRODUCED BY Pseudomonas cepacia</title><author>LEE, CHUL-HOON ; KIM, SUNGHO ; HYUN, BONGCHUL ; SUH, JUNG-WOO ; YON, CHANGSUEK ; KIM, CHANGONE ; LIM, YOONGHO ; KIM, CHOONGSUP</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4932-9f99a2ef375c8a211eae316b1fd89b4be2e5c792f3fd5562b35fc2dbb8ec616b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Anti-Bacterial Agents - biosynthesis</topic><topic>Anti-Bacterial Agents - isolation & purification</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibiotics. 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TAXONOMY, PRODUCTION, ISOLATION AND BIOLOGICAL ACTIVITY</atitle><jtitle>Journal of antibiotics</jtitle><addtitle>J. Antibiot.</addtitle><date>1994</date><risdate>1994</risdate><volume>47</volume><issue>12</issue><spage>1402</spage><epage>1405</epage><pages>1402-1405</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><coden>JANTAJ</coden><abstract>Cepacidine A is a potent antifungal antibiotic produced by Pseudomonas cepacia AF 2001. The compound was isolated from the fermentation broth with 1 vol isopropyl alcohol, followed by the collection of the precipitation formed upon concentration of the extract. Purification was effected by chromatography on Diaion HP-20, alumina and reversed phase C18 followed by TLC on silica gel. These techniques afforded the two closely related compounds, cepacidine A1 and cepacidine A2. A mixture of these two compounds called cepacidine A, showed high in vitro antifungal activity against the various animal and plant pathogenic fungi. 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| identifier | ISSN: 0021-8820 |
| ispartof | The Journal of Antibiotics, 1994/12/25, Vol.47(12), pp.1402-1405 |
| issn | 0021-8820 1881-1469 |
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| subjects | Anti-Bacterial Agents - biosynthesis Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - biosynthesis Antifungal Agents - isolation & purification Antifungal Agents - pharmacology Biological and medical sciences Blood Burkholderia cepacia - classification Burkholderia cepacia - metabolism Chromatography, High Pressure Liquid Chromatography, Ion Exchange Chromatography, Thin Layer Humans Medical sciences Peptides Pharmacology. Drug treatments Pseudomonas cepacia |
| title | CEPACIDINE A, A NOVEL ANTIFUNGAL ANTIBIOTIC PRODUCED BY Pseudomonas cepacia: I. TAXONOMY, PRODUCTION, ISOLATION AND BIOLOGICAL ACTIVITY |
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