Mapping the biodistribution and catabolism of 5-fluorouracil in tumor-bearing rats by chemical-shift selective 19F MR imaging

A chemical‐shift selective (CHESS) 19F MR imaging technique was used to map selectively the antineoplastic drug 5‐fluorouracil (5‐FU) and its major catabolite α‐fluoro‐β‐alanine (FBAL) in tumor‐bearing rats. The pulse sequence employed a CHESS RF saturation pulse to suppress either the 5‐FU or the F...

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