Proline, ascorbic acid, or thioredoxin affect jaundice and mortality in long evans cinnamon rats
The Long Evans Cinnamon (LEC) rat spontaneously develops fulminant hepatitis, which is usually lethal due to excess copper accumulation in the liver and is considered an animal model of Wilson's disease. LEC rats show a strong appetite for proline solution. Daily oral (p.o.) administration of p...
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| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 1995-11, Vol.52 (3), p.509-515 |
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| creator | Hawkins, Richard L. Mori, M. Inoue, M. Torii, K. |
| description | The Long Evans Cinnamon (LEC) rat spontaneously develops fulminant hepatitis, which is usually lethal due to excess copper accumulation in the liver and is considered an animal model of Wilson's disease. LEC rats show a strong appetite for proline solution. Daily oral (p.o.) administration of proline resulted in significant delay of mortality. Feeding a copper-deficient diet greatly delayed the onset of jaundice and mortality and voluntary consumption or p.o. administration of proline further delayed jaundice and prevented mortality. LEC rats also consume ascorbic acid solutions, and p.o. administration of ascorbate also results in a significant delay in the appearance of jaundice and mortality. Combined treatment with ascorbic acid and proline is additive to delay further jaundice and mortality. An endogenous antioxidant protein, thioredoxin, when infused by minipump IP, could also inhibit the incidence of jaundice. These results indicate that antioxidant treatment combined with proline may be of benefit in Wilson's disease and possibly other forms of hepatic dysfunction. |
| doi_str_mv | 10.1016/0091-3057(95)00118-G |
| format | Article |
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LEC rats show a strong appetite for proline solution. Daily oral (p.o.) administration of proline resulted in significant delay of mortality. Feeding a copper-deficient diet greatly delayed the onset of jaundice and mortality and voluntary consumption or p.o. administration of proline further delayed jaundice and prevented mortality. LEC rats also consume ascorbic acid solutions, and p.o. administration of ascorbate also results in a significant delay in the appearance of jaundice and mortality. Combined treatment with ascorbic acid and proline is additive to delay further jaundice and mortality. An endogenous antioxidant protein, thioredoxin, when infused by minipump IP, could also inhibit the incidence of jaundice. These results indicate that antioxidant treatment combined with proline may be of benefit in Wilson's disease and possibly other forms of hepatic dysfunction.</description><identifier>ISSN: 0091-3057</identifier><identifier>EISSN: 1873-5177</identifier><identifier>DOI: 10.1016/0091-3057(95)00118-G</identifier><identifier>PMID: 8545467</identifier><identifier>CODEN: PBBHAU</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Aging - physiology ; Animals ; Antioxidants ; Antioxidants - administration & dosage ; Antioxidants - therapeutic use ; Ascorbic acid ; Ascorbic Acid - administration & dosage ; Ascorbic Acid - therapeutic use ; Biological and medical sciences ; Branched chain amino acids ; Copper ; Copper - deficiency ; Diet ; General and cellular metabolism. Vitamins ; Hepatitis ; Infusion Pumps, Implantable ; Jaundice ; Jaundice - drug therapy ; Jaundice - genetics ; Jaundice - mortality ; Long Evans Cinnamon rat ; Male ; Medical sciences ; Pharmacology. Drug treatments ; Proline ; Proline - administration & dosage ; Proline - therapeutic use ; Rats ; Rats, Inbred Strains ; Thioredoxin ; Thioredoxins - administration & dosage ; Thioredoxins - therapeutic use ; Wilson's disease ; α-Tocopherol ; β-Carotene</subject><ispartof>Pharmacology, biochemistry and behavior, 1995-11, Vol.52 (3), p.509-515</ispartof><rights>1995</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-bb5131ffc5e04da2442ebd3deaf0f042a7c95a7d9afa04b9510a68f057ffc9393</citedby><cites>FETCH-LOGICAL-c478t-bb5131ffc5e04da2442ebd3deaf0f042a7c95a7d9afa04b9510a68f057ffc9393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0091-3057(95)00118-G$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2894493$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8545467$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hawkins, Richard L.</creatorcontrib><creatorcontrib>Mori, M.</creatorcontrib><creatorcontrib>Inoue, M.</creatorcontrib><creatorcontrib>Torii, K.</creatorcontrib><title>Proline, ascorbic acid, or thioredoxin affect jaundice and mortality in long evans cinnamon rats</title><title>Pharmacology, biochemistry and behavior</title><addtitle>Pharmacol Biochem Behav</addtitle><description>The Long Evans Cinnamon (LEC) rat spontaneously develops fulminant hepatitis, which is usually lethal due to excess copper accumulation in the liver and is considered an animal model of Wilson's disease. LEC rats show a strong appetite for proline solution. Daily oral (p.o.) administration of proline resulted in significant delay of mortality. Feeding a copper-deficient diet greatly delayed the onset of jaundice and mortality and voluntary consumption or p.o. administration of proline further delayed jaundice and prevented mortality. LEC rats also consume ascorbic acid solutions, and p.o. administration of ascorbate also results in a significant delay in the appearance of jaundice and mortality. Combined treatment with ascorbic acid and proline is additive to delay further jaundice and mortality. An endogenous antioxidant protein, thioredoxin, when infused by minipump IP, could also inhibit the incidence of jaundice. These results indicate that antioxidant treatment combined with proline may be of benefit in Wilson's disease and possibly other forms of hepatic dysfunction.</description><subject>Aging - physiology</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Antioxidants - administration & dosage</subject><subject>Antioxidants - therapeutic use</subject><subject>Ascorbic acid</subject><subject>Ascorbic Acid - administration & dosage</subject><subject>Ascorbic Acid - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Branched chain amino acids</subject><subject>Copper</subject><subject>Copper - deficiency</subject><subject>Diet</subject><subject>General and cellular metabolism. Vitamins</subject><subject>Hepatitis</subject><subject>Infusion Pumps, Implantable</subject><subject>Jaundice</subject><subject>Jaundice - drug therapy</subject><subject>Jaundice - genetics</subject><subject>Jaundice - mortality</subject><subject>Long Evans Cinnamon rat</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Proline</subject><subject>Proline - administration & dosage</subject><subject>Proline - therapeutic use</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Thioredoxin</subject><subject>Thioredoxins - administration & dosage</subject><subject>Thioredoxins - therapeutic use</subject><subject>Wilson's disease</subject><subject>α-Tocopherol</subject><subject>β-Carotene</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFLHDEUx0Ox2K31G1jIQUoLjk1mks3kIhRp14Kgh_Yc3yQvNjKT2GRW9Ns321326Okd3u__570fISecnXPGl18Z07zpmFSftfzCGOd9s3pDFrxXXSO5UgdksUfekfelPDDGRLtUh-Swl0KKpVqQu9ucxhDxjEKxKQ_BUrDBndGU6fwnpIwuPYdIwXu0M32AdXTBIoXo6JTyDGOYX2gFxhTvKT5BLNSGGGFKkWaYywfy1sNY8Hg3j8jvH99_XV411zern5ffrhsrVD83wyB5x723Eplw0ArR4uA6h-CZr1eDslqCcho8MDFoyRkse19fqxnd6e6IfNr2Pub0d41lNlMoFscRIqZ1MUqpVtWfKyi2oM2plIzePOYwQX4xnJmNWLOxZjbWjJbmv1izqrGPu_71MKHbh3Ym6_50t68iYfQZog1lj7W9FkJ3FbvYYlhdPAXMptiA0aILuQo2LoXX7_gHqE-Vdw</recordid><startdate>19951101</startdate><enddate>19951101</enddate><creator>Hawkins, Richard L.</creator><creator>Mori, M.</creator><creator>Inoue, M.</creator><creator>Torii, K.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19951101</creationdate><title>Proline, ascorbic acid, or thioredoxin affect jaundice and mortality in long evans cinnamon rats</title><author>Hawkins, Richard L. ; Mori, M. ; Inoue, M. ; Torii, K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-bb5131ffc5e04da2442ebd3deaf0f042a7c95a7d9afa04b9510a68f057ffc9393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Aging - physiology</topic><topic>Animals</topic><topic>Antioxidants</topic><topic>Antioxidants - administration & dosage</topic><topic>Antioxidants - therapeutic use</topic><topic>Ascorbic acid</topic><topic>Ascorbic Acid - administration & dosage</topic><topic>Ascorbic Acid - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Branched chain amino acids</topic><topic>Copper</topic><topic>Copper - deficiency</topic><topic>Diet</topic><topic>General and cellular metabolism. Vitamins</topic><topic>Hepatitis</topic><topic>Infusion Pumps, Implantable</topic><topic>Jaundice</topic><topic>Jaundice - drug therapy</topic><topic>Jaundice - genetics</topic><topic>Jaundice - mortality</topic><topic>Long Evans Cinnamon rat</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Proline</topic><topic>Proline - administration & dosage</topic><topic>Proline - therapeutic use</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Thioredoxin</topic><topic>Thioredoxins - administration & dosage</topic><topic>Thioredoxins - therapeutic use</topic><topic>Wilson's disease</topic><topic>α-Tocopherol</topic><topic>β-Carotene</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hawkins, Richard L.</creatorcontrib><creatorcontrib>Mori, M.</creatorcontrib><creatorcontrib>Inoue, M.</creatorcontrib><creatorcontrib>Torii, K.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hawkins, Richard L.</au><au>Mori, M.</au><au>Inoue, M.</au><au>Torii, K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Proline, ascorbic acid, or thioredoxin affect jaundice and mortality in long evans cinnamon rats</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>1995-11-01</date><risdate>1995</risdate><volume>52</volume><issue>3</issue><spage>509</spage><epage>515</epage><pages>509-515</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><coden>PBBHAU</coden><abstract>The Long Evans Cinnamon (LEC) rat spontaneously develops fulminant hepatitis, which is usually lethal due to excess copper accumulation in the liver and is considered an animal model of Wilson's disease. LEC rats show a strong appetite for proline solution. Daily oral (p.o.) administration of proline resulted in significant delay of mortality. Feeding a copper-deficient diet greatly delayed the onset of jaundice and mortality and voluntary consumption or p.o. administration of proline further delayed jaundice and prevented mortality. LEC rats also consume ascorbic acid solutions, and p.o. administration of ascorbate also results in a significant delay in the appearance of jaundice and mortality. Combined treatment with ascorbic acid and proline is additive to delay further jaundice and mortality. An endogenous antioxidant protein, thioredoxin, when infused by minipump IP, could also inhibit the incidence of jaundice. These results indicate that antioxidant treatment combined with proline may be of benefit in Wilson's disease and possibly other forms of hepatic dysfunction.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8545467</pmid><doi>10.1016/0091-3057(95)00118-G</doi><tpages>7</tpages></addata></record> |
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| subjects | Aging - physiology Animals Antioxidants Antioxidants - administration & dosage Antioxidants - therapeutic use Ascorbic acid Ascorbic Acid - administration & dosage Ascorbic Acid - therapeutic use Biological and medical sciences Branched chain amino acids Copper Copper - deficiency Diet General and cellular metabolism. Vitamins Hepatitis Infusion Pumps, Implantable Jaundice Jaundice - drug therapy Jaundice - genetics Jaundice - mortality Long Evans Cinnamon rat Male Medical sciences Pharmacology. Drug treatments Proline Proline - administration & dosage Proline - therapeutic use Rats Rats, Inbred Strains Thioredoxin Thioredoxins - administration & dosage Thioredoxins - therapeutic use Wilson's disease α-Tocopherol β-Carotene |
| title | Proline, ascorbic acid, or thioredoxin affect jaundice and mortality in long evans cinnamon rats |
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