Baroreflex sensitivity in men with recent myocardial infarction; impact of age
We investigated the effect of age on baroreflex sensitivity (BRS) in 39 male patients, who had survived their first myocardial infarction (MI) and in 15 age-matched controls. BRS was inversely related to age in both MI patients (r= −0.632, P
Gespeichert in:
| Veröffentlicht in: | European heart journal 1994-11, Vol.15 (11), p.1512-1519 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1519 |
|---|---|
| container_issue | 11 |
| container_start_page | 1512 |
| container_title | European heart journal |
| container_volume | 15 |
| creator | HARTIKAINEN, J. MÄNTYSAARI, M. MUSSALO, H. TAHVANAINEN, K. LÄNSIMIES, E. PYÖRÄLÄ, K. |
| description | We investigated the effect of age on baroreflex sensitivity (BRS) in 39 male patients, who had survived their first myocardial infarction (MI) and in 15 age-matched controls. BRS was inversely related to age in both MI patients (r= −0.632, P |
| doi_str_mv | 10.1093/oxfordjournals.eurheartj.a060423 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_77725445</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>77725445</sourcerecordid><originalsourceid>FETCH-LOGICAL-c393t-d50e17bfb95dc5b2ee78d1aa4e44f588b609770329cf20881f55b0d96dea04103</originalsourceid><addsrcrecordid>eNpVkMuO1DAQRS0EGpqBT0DKAiE2aew4fkRsGIbHgEYgxEOj3lgVp8y4SeLGdqD77wnqqCVWtbhHt6oOIc8YXTPa8Odh70LstmGKI_RpjVO8RYh5uwYqaV3xO2TFRFWVjazFXbKirBGllPrmPnmQ0pZSqiWTZ-RMaS64VCvy8RXEENH1uC8Sjsln_9vnQ-HHYsCx-OPzbRHR4piL4RAsxM5DP6cOos0-jC8KP-zA5iK4An7gQ3LPzYfho2Wek29v33y9vCqvP717f3lxXVre8Fx2giJTrWsb0VnRVohKdwygxrp2QutW0kYpyqvGuopqzZwQLe0a2SHQmlF-Tp4ee3cx_JowZTP4ZLHvYcQwJaOUqkRdixl8eQRtDCnNj5pd9APEg2HU_FNq_ldqTkrNonSueLzsmtoBu1PB4nDOnyw5JAu9izBan04Y51xWVM5YecR8yrg_xRB_mrlECXN1szEfXm82XH_-Yr7zv8ZZmS4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>77725445</pqid></control><display><type>article</type><title>Baroreflex sensitivity in men with recent myocardial infarction; impact of age</title><source>MEDLINE</source><source>Oxford University Press Journals Digital Archive Legacy</source><creator>HARTIKAINEN, J. ; MÄNTYSAARI, M. ; MUSSALO, H. ; TAHVANAINEN, K. ; LÄNSIMIES, E. ; PYÖRÄLÄ, K.</creator><creatorcontrib>HARTIKAINEN, J. ; MÄNTYSAARI, M. ; MUSSALO, H. ; TAHVANAINEN, K. ; LÄNSIMIES, E. ; PYÖRÄLÄ, K.</creatorcontrib><description><![CDATA[We investigated the effect of age on baroreflex sensitivity (BRS) in 39 male patients, who had survived their first myocardial infarction (MI) and in 15 age-matched controls. BRS was inversely related to age in both MI patients (r= −0.632, P<0.0001) and controls (r= − 0.706, P<0.0001). The relationship between BRS and age, however, was significantly different in MI patients as compared with healthy controls: BRS was markedly higher and the BRS-age regression slope was significantly steeper in controls than in MI patients. As a consequence, the decrease in BRS caused by MI (ΔBRS=age-specific expected BRS—measured BRS) was related inversely to age (r=−0.66, P<0.05) i.e. ΔBRS was greatest among young MI patients. However, the relative BRS (BRS%= measured BRS divided by the age-specific expected BRS) did not correlate with age. The average BRS% of MI patients was 37% lower than that of controls. MI size and left ventricular (LV) systolic function did not correlate with BRS. BRS correlated with variables related to cardiac diastolic function (peak late LV filling rate r=− 0.43, P<0.01, ratio of peak early to peak late LV filling rate r= −0.35, P<0.05), LV wall thickness (r=−0.34, P<0.05), exercise capacity (r=0.31, P<0.05) and the extent of ST-depression during exercise (r=−0.40, P<0.05), but all these correlations lost their significance after the adjustment for age. In conclusion, age is a factor that should be taken into consideration when evaluating the mechanisms of BRS impairment associated with different diseases. We suggest that, in addition to BRS, variables expressing the impairment of BRS (such as ΔBRS and BRS%) might be useful for the risk stratification of MI patients.]]></description><identifier>ISSN: 0195-668X</identifier><identifier>EISSN: 1522-9645</identifier><identifier>DOI: 10.1093/oxfordjournals.eurheartj.a060423</identifier><identifier>PMID: 7835367</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Age ; Age Factors ; Aged ; autonomic nervous function ; Autonomic Nervous System - physiology ; Autonomic Nervous System - physiopathology ; baroreceptor reflex ; Baroreflex - physiology ; Biological and medical sciences ; Cardiology. Vascular system ; Case-Control Studies ; Coronary heart disease ; Diastole - physiology ; Exercise Test ; Heart ; Humans ; Male ; Medical sciences ; Middle Aged ; myocardial infarction ; Myocardial Infarction - physiopathology ; Prognosis ; Regression Analysis ; Risk Factors ; Systole - physiology</subject><ispartof>European heart journal, 1994-11, Vol.15 (11), p.1512-1519</ispartof><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-d50e17bfb95dc5b2ee78d1aa4e44f588b609770329cf20881f55b0d96dea04103</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3336206$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7835367$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HARTIKAINEN, J.</creatorcontrib><creatorcontrib>MÄNTYSAARI, M.</creatorcontrib><creatorcontrib>MUSSALO, H.</creatorcontrib><creatorcontrib>TAHVANAINEN, K.</creatorcontrib><creatorcontrib>LÄNSIMIES, E.</creatorcontrib><creatorcontrib>PYÖRÄLÄ, K.</creatorcontrib><title>Baroreflex sensitivity in men with recent myocardial infarction; impact of age</title><title>European heart journal</title><addtitle>Eur Heart J</addtitle><description><![CDATA[We investigated the effect of age on baroreflex sensitivity (BRS) in 39 male patients, who had survived their first myocardial infarction (MI) and in 15 age-matched controls. BRS was inversely related to age in both MI patients (r= −0.632, P<0.0001) and controls (r= − 0.706, P<0.0001). The relationship between BRS and age, however, was significantly different in MI patients as compared with healthy controls: BRS was markedly higher and the BRS-age regression slope was significantly steeper in controls than in MI patients. As a consequence, the decrease in BRS caused by MI (ΔBRS=age-specific expected BRS—measured BRS) was related inversely to age (r=−0.66, P<0.05) i.e. ΔBRS was greatest among young MI patients. However, the relative BRS (BRS%= measured BRS divided by the age-specific expected BRS) did not correlate with age. The average BRS% of MI patients was 37% lower than that of controls. MI size and left ventricular (LV) systolic function did not correlate with BRS. BRS correlated with variables related to cardiac diastolic function (peak late LV filling rate r=− 0.43, P<0.01, ratio of peak early to peak late LV filling rate r= −0.35, P<0.05), LV wall thickness (r=−0.34, P<0.05), exercise capacity (r=0.31, P<0.05) and the extent of ST-depression during exercise (r=−0.40, P<0.05), but all these correlations lost their significance after the adjustment for age. In conclusion, age is a factor that should be taken into consideration when evaluating the mechanisms of BRS impairment associated with different diseases. We suggest that, in addition to BRS, variables expressing the impairment of BRS (such as ΔBRS and BRS%) might be useful for the risk stratification of MI patients.]]></description><subject>Adult</subject><subject>Age</subject><subject>Age Factors</subject><subject>Aged</subject><subject>autonomic nervous function</subject><subject>Autonomic Nervous System - physiology</subject><subject>Autonomic Nervous System - physiopathology</subject><subject>baroreceptor reflex</subject><subject>Baroreflex - physiology</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Case-Control Studies</subject><subject>Coronary heart disease</subject><subject>Diastole - physiology</subject><subject>Exercise Test</subject><subject>Heart</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>myocardial infarction</subject><subject>Myocardial Infarction - physiopathology</subject><subject>Prognosis</subject><subject>Regression Analysis</subject><subject>Risk Factors</subject><subject>Systole - physiology</subject><issn>0195-668X</issn><issn>1522-9645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkMuO1DAQRS0EGpqBT0DKAiE2aew4fkRsGIbHgEYgxEOj3lgVp8y4SeLGdqD77wnqqCVWtbhHt6oOIc8YXTPa8Odh70LstmGKI_RpjVO8RYh5uwYqaV3xO2TFRFWVjazFXbKirBGllPrmPnmQ0pZSqiWTZ-RMaS64VCvy8RXEENH1uC8Sjsln_9vnQ-HHYsCx-OPzbRHR4piL4RAsxM5DP6cOos0-jC8KP-zA5iK4An7gQ3LPzYfho2Wek29v33y9vCqvP717f3lxXVre8Fx2giJTrWsb0VnRVohKdwygxrp2QutW0kYpyqvGuopqzZwQLe0a2SHQmlF-Tp4ee3cx_JowZTP4ZLHvYcQwJaOUqkRdixl8eQRtDCnNj5pd9APEg2HU_FNq_ldqTkrNonSueLzsmtoBu1PB4nDOnyw5JAu9izBan04Y51xWVM5YecR8yrg_xRB_mrlECXN1szEfXm82XH_-Yr7zv8ZZmS4</recordid><startdate>19941101</startdate><enddate>19941101</enddate><creator>HARTIKAINEN, J.</creator><creator>MÄNTYSAARI, M.</creator><creator>MUSSALO, H.</creator><creator>TAHVANAINEN, K.</creator><creator>LÄNSIMIES, E.</creator><creator>PYÖRÄLÄ, K.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19941101</creationdate><title>Baroreflex sensitivity in men with recent myocardial infarction; impact of age</title><author>HARTIKAINEN, J. ; MÄNTYSAARI, M. ; MUSSALO, H. ; TAHVANAINEN, K. ; LÄNSIMIES, E. ; PYÖRÄLÄ, K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-d50e17bfb95dc5b2ee78d1aa4e44f588b609770329cf20881f55b0d96dea04103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adult</topic><topic>Age</topic><topic>Age Factors</topic><topic>Aged</topic><topic>autonomic nervous function</topic><topic>Autonomic Nervous System - physiology</topic><topic>Autonomic Nervous System - physiopathology</topic><topic>baroreceptor reflex</topic><topic>Baroreflex - physiology</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Case-Control Studies</topic><topic>Coronary heart disease</topic><topic>Diastole - physiology</topic><topic>Exercise Test</topic><topic>Heart</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>myocardial infarction</topic><topic>Myocardial Infarction - physiopathology</topic><topic>Prognosis</topic><topic>Regression Analysis</topic><topic>Risk Factors</topic><topic>Systole - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HARTIKAINEN, J.</creatorcontrib><creatorcontrib>MÄNTYSAARI, M.</creatorcontrib><creatorcontrib>MUSSALO, H.</creatorcontrib><creatorcontrib>TAHVANAINEN, K.</creatorcontrib><creatorcontrib>LÄNSIMIES, E.</creatorcontrib><creatorcontrib>PYÖRÄLÄ, K.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HARTIKAINEN, J.</au><au>MÄNTYSAARI, M.</au><au>MUSSALO, H.</au><au>TAHVANAINEN, K.</au><au>LÄNSIMIES, E.</au><au>PYÖRÄLÄ, K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Baroreflex sensitivity in men with recent myocardial infarction; impact of age</atitle><jtitle>European heart journal</jtitle><addtitle>Eur Heart J</addtitle><date>1994-11-01</date><risdate>1994</risdate><volume>15</volume><issue>11</issue><spage>1512</spage><epage>1519</epage><pages>1512-1519</pages><issn>0195-668X</issn><eissn>1522-9645</eissn><abstract><![CDATA[We investigated the effect of age on baroreflex sensitivity (BRS) in 39 male patients, who had survived their first myocardial infarction (MI) and in 15 age-matched controls. BRS was inversely related to age in both MI patients (r= −0.632, P<0.0001) and controls (r= − 0.706, P<0.0001). The relationship between BRS and age, however, was significantly different in MI patients as compared with healthy controls: BRS was markedly higher and the BRS-age regression slope was significantly steeper in controls than in MI patients. As a consequence, the decrease in BRS caused by MI (ΔBRS=age-specific expected BRS—measured BRS) was related inversely to age (r=−0.66, P<0.05) i.e. ΔBRS was greatest among young MI patients. However, the relative BRS (BRS%= measured BRS divided by the age-specific expected BRS) did not correlate with age. The average BRS% of MI patients was 37% lower than that of controls. MI size and left ventricular (LV) systolic function did not correlate with BRS. BRS correlated with variables related to cardiac diastolic function (peak late LV filling rate r=− 0.43, P<0.01, ratio of peak early to peak late LV filling rate r= −0.35, P<0.05), LV wall thickness (r=−0.34, P<0.05), exercise capacity (r=0.31, P<0.05) and the extent of ST-depression during exercise (r=−0.40, P<0.05), but all these correlations lost their significance after the adjustment for age. In conclusion, age is a factor that should be taken into consideration when evaluating the mechanisms of BRS impairment associated with different diseases. We suggest that, in addition to BRS, variables expressing the impairment of BRS (such as ΔBRS and BRS%) might be useful for the risk stratification of MI patients.]]></abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>7835367</pmid><doi>10.1093/oxfordjournals.eurheartj.a060423</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0195-668X |
| ispartof | European heart journal, 1994-11, Vol.15 (11), p.1512-1519 |
| issn | 0195-668X 1522-9645 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77725445 |
| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | Adult Age Age Factors Aged autonomic nervous function Autonomic Nervous System - physiology Autonomic Nervous System - physiopathology baroreceptor reflex Baroreflex - physiology Biological and medical sciences Cardiology. Vascular system Case-Control Studies Coronary heart disease Diastole - physiology Exercise Test Heart Humans Male Medical sciences Middle Aged myocardial infarction Myocardial Infarction - physiopathology Prognosis Regression Analysis Risk Factors Systole - physiology |
| title | Baroreflex sensitivity in men with recent myocardial infarction; impact of age |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T19%3A47%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Baroreflex%20sensitivity%20in%20men%20with%20recent%20myocardial%20infarction;%20impact%20of%20age&rft.jtitle=European%20heart%20journal&rft.au=HARTIKAINEN,%20J.&rft.date=1994-11-01&rft.volume=15&rft.issue=11&rft.spage=1512&rft.epage=1519&rft.pages=1512-1519&rft.issn=0195-668X&rft.eissn=1522-9645&rft_id=info:doi/10.1093/oxfordjournals.eurheartj.a060423&rft_dat=%3Cproquest_cross%3E77725445%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=77725445&rft_id=info:pmid/7835367&rfr_iscdi=true |