Antiproliferative effects of sodium butyrate in adriamycin-sensitive and -resistant human cancer cell lines
The proliferation of the MCF7 and MCF7-A (adrlamyclnresistant) and KB-3-1 and KB-A (adrlamycln-resistant) cell lines was arrested by sodium butyrate (NaBut) at 1 mM or higher concentrations. In the MCF7 and MCF7-A cell lines, an accumulation In the d phase was observed, whereas the KB-3-1 and KB-A c...
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| Veröffentlicht in: | Anti-cancer drugs 1994-10, Vol.5 (5), p.548-556 |
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| creator | Fagot, Dominique Buquet-Fagot, Christine Lallemand, François Mester, Jan |
| description | The proliferation of the MCF7 and MCF7-A (adrlamyclnresistant) and KB-3-1 and KB-A (adrlamycln-resistant) cell lines was arrested by sodium butyrate (NaBut) at 1 mM or higher concentrations. In the MCF7 and MCF7-A cell lines, an accumulation In the d phase was observed, whereas the KB-3-1 and KB-A cell lines accumulated In both G1 and G2/M phases. The level of the mRNA coded by the ʼearly G1ʼ/gene c-myc was high In all these cell lines, and was only transiently decreased by NaBut treatment. The ʼlateʼ mRNA coding for the proliferating cell nuclear antigen (PCNA) was also strongly expressed In all the cell lines studied; Incubation with NaBut caused a decrease of the PCNA mRNA In the MCF7 and MCF7-A cells but not In the KB-3-1 and KB-A cells. The antl-oncoproteln p105RB was undetectable In the MCF7 and MCF7-A cells, while the KB-3-1 as well as KB-A cells contained a high level of this protein. Neither the content nor the apparent state of phosphorylatlon of the RB protein were affected by incubation (up to 48 h) with NaBut. |
| doi_str_mv | 10.1097/00001813-199410000-00006 |
| format | Article |
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In the MCF7 and MCF7-A cell lines, an accumulation In the d phase was observed, whereas the KB-3-1 and KB-A cell lines accumulated In both G1 and G2/M phases. The level of the mRNA coded by the ʼearly G1ʼ/gene c-myc was high In all these cell lines, and was only transiently decreased by NaBut treatment. The ʼlateʼ mRNA coding for the proliferating cell nuclear antigen (PCNA) was also strongly expressed In all the cell lines studied; Incubation with NaBut caused a decrease of the PCNA mRNA In the MCF7 and MCF7-A cells but not In the KB-3-1 and KB-A cells. The antl-oncoproteln p105RB was undetectable In the MCF7 and MCF7-A cells, while the KB-3-1 as well as KB-A cells contained a high level of this protein. Neither the content nor the apparent state of phosphorylatlon of the RB protein were affected by incubation (up to 48 h) with NaBut.</description><identifier>ISSN: 0959-4973</identifier><identifier>EISSN: 1473-5741</identifier><identifier>DOI: 10.1097/00001813-199410000-00006</identifier><identifier>PMID: 7858287</identifier><language>eng</language><publisher>England: Lippincott-Raven Publishers</publisher><subject>Butyrates - pharmacology ; Butyric Acid ; Cell Division - drug effects ; Cycloheximide - pharmacology ; Dactinomycin - pharmacology ; Doxorubicin - pharmacology ; Drug Resistance ; Gene Expression Regulation, Neoplastic - drug effects ; Humans ; Neoplasm Proteins - analysis ; Neoplasm Proteins - biosynthesis ; Proliferating Cell Nuclear Antigen - biosynthesis ; Retinoblastoma Protein - biosynthesis ; RNA, Neoplasm - biosynthesis ; Tumor Cells, Cultured</subject><ispartof>Anti-cancer drugs, 1994-10, Vol.5 (5), p.548-556</ispartof><rights>Lippincott-Raven Publishers.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2706-a293b4c5028189de44faf97bf0b0d56e896210628284d8fa70c4c5a1ce796e293</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7858287$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fagot, Dominique</creatorcontrib><creatorcontrib>Buquet-Fagot, Christine</creatorcontrib><creatorcontrib>Lallemand, François</creatorcontrib><creatorcontrib>Mester, Jan</creatorcontrib><title>Antiproliferative effects of sodium butyrate in adriamycin-sensitive and -resistant human cancer cell lines</title><title>Anti-cancer drugs</title><addtitle>Anticancer Drugs</addtitle><description>The proliferation of the MCF7 and MCF7-A (adrlamyclnresistant) and KB-3-1 and KB-A (adrlamycln-resistant) cell lines was arrested by sodium butyrate (NaBut) at 1 mM or higher concentrations. In the MCF7 and MCF7-A cell lines, an accumulation In the d phase was observed, whereas the KB-3-1 and KB-A cell lines accumulated In both G1 and G2/M phases. The level of the mRNA coded by the ʼearly G1ʼ/gene c-myc was high In all these cell lines, and was only transiently decreased by NaBut treatment. The ʼlateʼ mRNA coding for the proliferating cell nuclear antigen (PCNA) was also strongly expressed In all the cell lines studied; Incubation with NaBut caused a decrease of the PCNA mRNA In the MCF7 and MCF7-A cells but not In the KB-3-1 and KB-A cells. The antl-oncoproteln p105RB was undetectable In the MCF7 and MCF7-A cells, while the KB-3-1 as well as KB-A cells contained a high level of this protein. Neither the content nor the apparent state of phosphorylatlon of the RB protein were affected by incubation (up to 48 h) with NaBut.</description><subject>Butyrates - pharmacology</subject><subject>Butyric Acid</subject><subject>Cell Division - drug effects</subject><subject>Cycloheximide - pharmacology</subject><subject>Dactinomycin - pharmacology</subject><subject>Doxorubicin - pharmacology</subject><subject>Drug Resistance</subject><subject>Gene Expression Regulation, Neoplastic - drug effects</subject><subject>Humans</subject><subject>Neoplasm Proteins - analysis</subject><subject>Neoplasm Proteins - biosynthesis</subject><subject>Proliferating Cell Nuclear Antigen - biosynthesis</subject><subject>Retinoblastoma Protein - biosynthesis</subject><subject>RNA, Neoplasm - biosynthesis</subject><subject>Tumor Cells, Cultured</subject><issn>0959-4973</issn><issn>1473-5741</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UU1PxCAQJUaj6-pPMOHkDYWWFjga41di4kXPhNIhi7ZUgWr238u6qzc5DGHee8zMG4QwoxeMKnFJy2GS1YQpxdnmRTah3UMLxkVNGsHZPlpQ1SjClaiP0HFKr4VR8vUhOhSykZUUC_R2FbJ_j9PgHUST_SdgcA5sTnhyOE29n0fczXldQMA-YNNHb8a19YEkCMn_SEzoMYmQfMomZLyaRxOwNcFCxBaGAQ8-QDpBB84MCU539xK93N48X9-Tx6e7h-urR2IrQVtiKlV33Da0kkyqHjh3xinROdrRvmlBqrZitK3KALyXzghqC9swC0K1UMRLdL79t8z1MUPKevRp04YJMM1JCyGqhrVNIcot0cYppQhOv0c_mrjWjOqNz_rXZ_3n80-qLdKzXY25G6H_E-6MLTjf4l_TkCGmt2H-gqhXYIa80v-tr_4Gl8OJcA</recordid><startdate>199410</startdate><enddate>199410</enddate><creator>Fagot, Dominique</creator><creator>Buquet-Fagot, Christine</creator><creator>Lallemand, François</creator><creator>Mester, Jan</creator><general>Lippincott-Raven Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199410</creationdate><title>Antiproliferative effects of sodium butyrate in adriamycin-sensitive and -resistant human cancer cell lines</title><author>Fagot, Dominique ; Buquet-Fagot, Christine ; Lallemand, François ; Mester, Jan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2706-a293b4c5028189de44faf97bf0b0d56e896210628284d8fa70c4c5a1ce796e293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Butyrates - pharmacology</topic><topic>Butyric Acid</topic><topic>Cell Division - drug effects</topic><topic>Cycloheximide - pharmacology</topic><topic>Dactinomycin - pharmacology</topic><topic>Doxorubicin - pharmacology</topic><topic>Drug Resistance</topic><topic>Gene Expression Regulation, Neoplastic - drug effects</topic><topic>Humans</topic><topic>Neoplasm Proteins - analysis</topic><topic>Neoplasm Proteins - biosynthesis</topic><topic>Proliferating Cell Nuclear Antigen - biosynthesis</topic><topic>Retinoblastoma Protein - biosynthesis</topic><topic>RNA, Neoplasm - biosynthesis</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fagot, Dominique</creatorcontrib><creatorcontrib>Buquet-Fagot, Christine</creatorcontrib><creatorcontrib>Lallemand, François</creatorcontrib><creatorcontrib>Mester, Jan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Anti-cancer drugs</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fagot, Dominique</au><au>Buquet-Fagot, Christine</au><au>Lallemand, François</au><au>Mester, Jan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antiproliferative effects of sodium butyrate in adriamycin-sensitive and -resistant human cancer cell lines</atitle><jtitle>Anti-cancer drugs</jtitle><addtitle>Anticancer Drugs</addtitle><date>1994-10</date><risdate>1994</risdate><volume>5</volume><issue>5</issue><spage>548</spage><epage>556</epage><pages>548-556</pages><issn>0959-4973</issn><eissn>1473-5741</eissn><abstract>The proliferation of the MCF7 and MCF7-A (adrlamyclnresistant) and KB-3-1 and KB-A (adrlamycln-resistant) cell lines was arrested by sodium butyrate (NaBut) at 1 mM or higher concentrations. In the MCF7 and MCF7-A cell lines, an accumulation In the d phase was observed, whereas the KB-3-1 and KB-A cell lines accumulated In both G1 and G2/M phases. The level of the mRNA coded by the ʼearly G1ʼ/gene c-myc was high In all these cell lines, and was only transiently decreased by NaBut treatment. The ʼlateʼ mRNA coding for the proliferating cell nuclear antigen (PCNA) was also strongly expressed In all the cell lines studied; Incubation with NaBut caused a decrease of the PCNA mRNA In the MCF7 and MCF7-A cells but not In the KB-3-1 and KB-A cells. The antl-oncoproteln p105RB was undetectable In the MCF7 and MCF7-A cells, while the KB-3-1 as well as KB-A cells contained a high level of this protein. Neither the content nor the apparent state of phosphorylatlon of the RB protein were affected by incubation (up to 48 h) with NaBut.</abstract><cop>England</cop><pub>Lippincott-Raven Publishers</pub><pmid>7858287</pmid><doi>10.1097/00001813-199410000-00006</doi><tpages>9</tpages></addata></record> |
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| ispartof | Anti-cancer drugs, 1994-10, Vol.5 (5), p.548-556 |
| issn | 0959-4973 1473-5741 |
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| source | MEDLINE; Journals@Ovid Ovid Autoload |
| subjects | Butyrates - pharmacology Butyric Acid Cell Division - drug effects Cycloheximide - pharmacology Dactinomycin - pharmacology Doxorubicin - pharmacology Drug Resistance Gene Expression Regulation, Neoplastic - drug effects Humans Neoplasm Proteins - analysis Neoplasm Proteins - biosynthesis Proliferating Cell Nuclear Antigen - biosynthesis Retinoblastoma Protein - biosynthesis RNA, Neoplasm - biosynthesis Tumor Cells, Cultured |
| title | Antiproliferative effects of sodium butyrate in adriamycin-sensitive and -resistant human cancer cell lines |
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