A Monoclonal Antibody That Recognizes the GPIIb/IIIa Antagonist DMP 728: Reversal of the Effects of DMP 728 on Platelet Aggregation and Bleeding Time in the Dog

Since hemorrhagic events represent a major safety concern associated with the use of new antithrombotic therapies such as glycoprotein (GP) IIb/IIIa receptor blockade, we evaluated the ability of a monoclonal antibody recognizing DMP 728 (cyclic [D-2-aminobutyryl-N2-methyl-L-argininyl-glycyl-L-aspar...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 1995-12, Vol.15 (12), p.2195-2199
Hauptverfasser:	Reilly, Thomas M, Mousa, Shaker A, Racanelli, Adrienne L, Thoolen, Martin J, Flint, Sandra K, Bozarth, Jeffrey M, Mu, Dun X, Walton, Harry L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - immunology Bleeding Time Dogs Female Humans In Vitro Techniques Male Mesylates - antagonists & inhibitors Mesylates - immunology Peptides, Cyclic - antagonists & inhibitors Peptides, Cyclic - immunology Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - immunology Platelet Glycoprotein GPIIb-IIIa Complex - antagonists & inhibitors
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