The effects of morphine in the consummatory contrast paradigm
Rats shifted from 32% to 4% sucrose show a negative contrast effect, licking significantly less than animals that receive only 4% sucrose. The effects of morphine sulfate (0.5, 1.0, 2.0, 4.0, 8.0, and 16.0 mg/kg) on negative contrast were investigated in four experiments. Contrast was reduced on bot...
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| Veröffentlicht in: | Psychopharmacologia 1987-09, Vol.93 (1), p.51-58 |
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| creator | ROWAN, G. A FLAHERTY, C. F |
| description | Rats shifted from 32% to 4% sucrose show a negative contrast effect, licking significantly less than animals that receive only 4% sucrose. The effects of morphine sulfate (0.5, 1.0, 2.0, 4.0, 8.0, and 16.0 mg/kg) on negative contrast were investigated in four experiments. Contrast was reduced on both the 1st and 2nd postshift day by the 4.0 and 8.0 mg/kg doses, but the effects were less robust than those seen with the benzodiazepines. The effects of morphine on contrast were dissociable from simple increases in sucrose consumption. Naloxone (0.25, 0.5, and 1.0 mg/kg) had no effect on contrast or sucrose intake. However, the contrast-reducing effect of morphine (4.0 mg/kg) was blocked by pretreatment with naloxone (0.50 mg/kg). The results are discussed in terms of other anxiolytic screening paradigms that have obtained "partial anxiolytic effects" using morphine. |
| doi_str_mv | 10.1007/bf02439586 |
| format | Article |
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The results are discussed in terms of other anxiolytic screening paradigms that have obtained "partial anxiolytic effects" using morphine.</description><identifier>ISSN: 0033-3158</identifier><identifier>EISSN: 1432-2072</identifier><identifier>DOI: 10.1007/bf02439586</identifier><identifier>PMID: 2819925</identifier><identifier>CODEN: PSYPAG</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Analgesics ; Animals ; Arousal - drug effects ; Biological and medical sciences ; Consummatory Behavior - drug effects ; Dose-Response Relationship, Drug ; Drinking - drug effects ; Male ; Medical sciences ; Morphine - pharmacology ; Naloxone - pharmacology ; Neuropharmacology ; Pharmacology. 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A</creatorcontrib><creatorcontrib>FLAHERTY, C. F</creatorcontrib><title>The effects of morphine in the consummatory contrast paradigm</title><title>Psychopharmacologia</title><addtitle>Psychopharmacology (Berl)</addtitle><description>Rats shifted from 32% to 4% sucrose show a negative contrast effect, licking significantly less than animals that receive only 4% sucrose. The effects of morphine sulfate (0.5, 1.0, 2.0, 4.0, 8.0, and 16.0 mg/kg) on negative contrast were investigated in four experiments. Contrast was reduced on both the 1st and 2nd postshift day by the 4.0 and 8.0 mg/kg doses, but the effects were less robust than those seen with the benzodiazepines. The effects of morphine on contrast were dissociable from simple increases in sucrose consumption. Naloxone (0.25, 0.5, and 1.0 mg/kg) had no effect on contrast or sucrose intake. However, the contrast-reducing effect of morphine (4.0 mg/kg) was blocked by pretreatment with naloxone (0.50 mg/kg). The results are discussed in terms of other anxiolytic screening paradigms that have obtained "partial anxiolytic effects" using morphine.</description><subject>Analgesics</subject><subject>Animals</subject><subject>Arousal - drug effects</subject><subject>Biological and medical sciences</subject><subject>Consummatory Behavior - drug effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drinking - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Morphine - pharmacology</subject><subject>Naloxone - pharmacology</subject><subject>Neuropharmacology</subject><subject>Pharmacology. 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Drug treatments</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Receptors, Opioid - drug effects</topic><topic>Reflex, Startle - drug effects</topic><topic>Taste - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ROWAN, G. A</creatorcontrib><creatorcontrib>FLAHERTY, C. F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Psychopharmacologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ROWAN, G. A</au><au>FLAHERTY, C. F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of morphine in the consummatory contrast paradigm</atitle><jtitle>Psychopharmacologia</jtitle><addtitle>Psychopharmacology (Berl)</addtitle><date>1987-09</date><risdate>1987</risdate><volume>93</volume><issue>1</issue><spage>51</spage><epage>58</epage><pages>51-58</pages><issn>0033-3158</issn><eissn>1432-2072</eissn><coden>PSYPAG</coden><abstract>Rats shifted from 32% to 4% sucrose show a negative contrast effect, licking significantly less than animals that receive only 4% sucrose. The effects of morphine sulfate (0.5, 1.0, 2.0, 4.0, 8.0, and 16.0 mg/kg) on negative contrast were investigated in four experiments. Contrast was reduced on both the 1st and 2nd postshift day by the 4.0 and 8.0 mg/kg doses, but the effects were less robust than those seen with the benzodiazepines. The effects of morphine on contrast were dissociable from simple increases in sucrose consumption. Naloxone (0.25, 0.5, and 1.0 mg/kg) had no effect on contrast or sucrose intake. However, the contrast-reducing effect of morphine (4.0 mg/kg) was blocked by pretreatment with naloxone (0.50 mg/kg). The results are discussed in terms of other anxiolytic screening paradigms that have obtained "partial anxiolytic effects" using morphine.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>2819925</pmid><doi>10.1007/bf02439586</doi><tpages>8</tpages></addata></record> |
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| subjects | Analgesics Animals Arousal - drug effects Biological and medical sciences Consummatory Behavior - drug effects Dose-Response Relationship, Drug Drinking - drug effects Male Medical sciences Morphine - pharmacology Naloxone - pharmacology Neuropharmacology Pharmacology. Drug treatments Rats Rats, Inbred Strains Receptors, Opioid - drug effects Reflex, Startle - drug effects Taste - drug effects |
| title | The effects of morphine in the consummatory contrast paradigm |
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