Simultaneous Increases of Extracellular Monoamines in Microdialysates from Hypothalamus of Conscious Rats by Duloxetine, a Dual Serotonin and Norepinephrine Uptake Inhibitor

Duloxetine (LY248686, [+]-N-methyl-3-(1-napthalenyloxy)-2-thiophene-propanamine) is a potent dual inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE) uptake in hypothalamus and cerebral cortex of rat brain (Wong et al. 1993; Fuller et al. 1994). Consistent with the dual mechan...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 1995-07, Vol.12 (4), p.287-295
Hauptverfasser:	ENGLEMAN, E. A, PERRY, K. W, MAYLE, D. A, WONG, D. T
Format:	Artikel
Sprache:	eng
Schlagworte:	3,4-Dihydroxyphenylacetic Acid - metabolism Adrenergic Uptake Inhibitors - pharmacology Animals Biogenic Monoamines - metabolism Biological and medical sciences Blood Platelets - drug effects Blood Platelets - metabolism Dopamine - metabolism Dose-Response Relationship, Drug Duloxetine Hydrochloride Hypothalamus - drug effects Hypothalamus - metabolism In Vitro Techniques Male Medical sciences Microdialysis Neuropharmacology Norepinephrine - metabolism Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Sprague-Dawley Serotonin - metabolism Serotonin Uptake Inhibitors - pharmacology Synaptosomes - drug effects Synaptosomes - metabolism Thiophenes - pharmacology
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