Localization and quantification of the dopamine transporter: comparison of [ 3H]WIN 35,428 and [ 125I]RTI-55

Transport into the presynaptic terminal by the dopamine transporter is the primary mechanism for removing dopamine from the synaptic cleft. This transporter is a specific marker for dopamine terminals and is a primary site for CNS actions of cocaine. Several radioligands have been developed for anal...

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Veröffentlicht in:	Brain research 1995-09, Vol.690 (2), p.217-224
Hauptverfasser:	Coulter, Cynthia L., Kevin Happe, H., Bergman, Debra A., Charles Murrin, L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoradiography Biochemistry and metabolism Biological and medical sciences Brain Chemistry - physiology Carrier Proteins - analysis Central nervous system Cocaine - analogs & derivatives Cocaine - metabolism Cocaine receptor Dopamine - metabolism Dopamine Plasma Membrane Transport Proteins Dopamine transporter Dopamine uptake Fundamental and applied biological sciences. Psychology Iodine Radioisotopes Membrane Glycoproteins Membrane Transport Proteins Nerve Tissue Proteins - analysis Quantitative autoradiography Radioligand Assay Rats Rats, Sprague-Dawley RTI-55 Tritium Vertebrates: nervous system and sense organs WIN 35,428
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