Sensitivity of the hypothalamic-pituitary-adrenal system of pigeons (Columbia livia domestica) to suppression by dexamethasone, cortisol, and prednisolone
The sensitivity of the hypothalamic-pituitary-adrenal system in pigeons (Columba livia domestica) to glucocorticoid feedback was studied after single intravenous administration of dexamethasone (500, 100, 50, 10, 5, 1, 0.5, and 0.1 microgram/kg), cortisol (15,000, 3000, 1500, 300, 150, 30, 15, and 3...
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| Veröffentlicht in: | Avian diseases 1994-07, Vol.38 (3), p.435-445 |
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| creator | Westerhof, I. (Utrecht University, Utrecht, The Netherlands) Brom, W.E. van den Mol, J.A Lumeij, J.T Rijnberk, A |
| description | The sensitivity of the hypothalamic-pituitary-adrenal system in pigeons (Columba livia domestica) to glucocorticoid feedback was studied after single intravenous administration of dexamethasone (500, 100, 50, 10, 5, 1, 0.5, and 0.1 microgram/kg), cortisol (15,000, 3000, 1500, 300, 150, 30, 15, and 3 microgram/kg), and prednisolone (3500, 700, 350, 70, 35, 7, 3.5, 0.7, and 0.35 microgram/kg). Dose responses, the threshold doses, and the onset of maximum suppression were determined by measuring plasma corticosterone concentrations around the expected peak of plasma corticosterone in pigeons kept on a shifted-light regimen. At 52 hr following the highest dose of dexamethasone, and at 48 hr following the highest doses of cortisol and prednisolone, plasma corticosterone concentrations were similar to the initial values and to the control values. Following the minimum doses that resulted in suppression of the normal diurnal variation in plasma corticosterone concentration (0.5 microgram dexamethasone/kg, 15 microgram cortisol/kg, and 0.7 microgram prednisolone/kg), plasma corticosterone concentrations were similar to values of the control group and to initial values within 24 hr. The onset of suppression of plasma corticosterone concentrations was between 30 and 60 min following 1 microgram dexamethasone/kg, 7 microgram prednisolone/kg, or 30 microgram cortisol/kg. Suppression was greatest at 60 min following prednisolone and cortisol administration, and at 90 min following dexamethasone administration. It is concluded that the hypothalamic-pituitary-adrenal system of pigeons reacts to exogenous glucocorticoids by early delayed feedback, is more sensitive to suppression by glucocorticoids than that of mammals, and is suppressed for the longest time by dexamethasone. These observations indicate that some of the side effects of glucocorticoid therapy are likely to be at least as frequent and as severe in birds as in mammals |
| doi_str_mv | 10.2307/1592063 |
| format | Article |
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(Utrecht University, Utrecht, The Netherlands) ; Brom, W.E. van den ; Mol, J.A ; Lumeij, J.T ; Rijnberk, A</creator><creatorcontrib>Westerhof, I. (Utrecht University, Utrecht, The Netherlands) ; Brom, W.E. van den ; Mol, J.A ; Lumeij, J.T ; Rijnberk, A</creatorcontrib><description>The sensitivity of the hypothalamic-pituitary-adrenal system in pigeons (Columba livia domestica) to glucocorticoid feedback was studied after single intravenous administration of dexamethasone (500, 100, 50, 10, 5, 1, 0.5, and 0.1 microgram/kg), cortisol (15,000, 3000, 1500, 300, 150, 30, 15, and 3 microgram/kg), and prednisolone (3500, 700, 350, 70, 35, 7, 3.5, 0.7, and 0.35 microgram/kg). Dose responses, the threshold doses, and the onset of maximum suppression were determined by measuring plasma corticosterone concentrations around the expected peak of plasma corticosterone in pigeons kept on a shifted-light regimen. At 52 hr following the highest dose of dexamethasone, and at 48 hr following the highest doses of cortisol and prednisolone, plasma corticosterone concentrations were similar to the initial values and to the control values. Following the minimum doses that resulted in suppression of the normal diurnal variation in plasma corticosterone concentration (0.5 microgram dexamethasone/kg, 15 microgram cortisol/kg, and 0.7 microgram prednisolone/kg), plasma corticosterone concentrations were similar to values of the control group and to initial values within 24 hr. The onset of suppression of plasma corticosterone concentrations was between 30 and 60 min following 1 microgram dexamethasone/kg, 7 microgram prednisolone/kg, or 30 microgram cortisol/kg. Suppression was greatest at 60 min following prednisolone and cortisol administration, and at 90 min following dexamethasone administration. It is concluded that the hypothalamic-pituitary-adrenal system of pigeons reacts to exogenous glucocorticoids by early delayed feedback, is more sensitive to suppression by glucocorticoids than that of mammals, and is suppressed for the longest time by dexamethasone. These observations indicate that some of the side effects of glucocorticoid therapy are likely to be at least as frequent and as severe in birds as in mammals</description><identifier>ISSN: 0005-2086</identifier><identifier>EISSN: 1938-4351</identifier><identifier>DOI: 10.2307/1592063</identifier><identifier>PMID: 7832695</identifier><language>eng</language><publisher>United States: American Association of Avian Pathologists, Inc</publisher><subject>Animals ; Birds ; Blood plasma ; CEREBRO ; Circadian Rhythm - physiology ; Columbidae - physiology ; Control groups ; Corticosterone ; DEXAMETHASONE ; Dexamethasone - administration & dosage ; Dexamethasone - pharmacology ; Dose response relationship ; ENCEPHALE ; Environment, Controlled ; ESTEROIDES ; Feedback ; Female ; GLANDULA PITUITARIA ; GLANDULAS SUPRARRENALES ; GLUCOCORTICOIDE ; GLUCOCORTICOIDES ; Glucocorticoids ; Human resources ; Hydrocortisone - administration & dosage ; Hydrocortisone - pharmacology ; HYPOPHYSE ; Hypothalamo-Hypophyseal System - drug effects ; Hypothalamo-Hypophyseal System - physiology ; INJECTION ; Intravenous injections ; INYECCION ; Light ; Male ; Mammals ; PALOMA ; PIGEON ; Pigeons ; Pituitary-Adrenal System - drug effects ; Pituitary-Adrenal System - physiology ; Prednisolone - administration & dosage ; Prednisolone - pharmacology ; RITMOS BIOLOGICOS ; RYTHME BIOLOGIQUE ; STEROIDE ; SURRENALE</subject><ispartof>Avian diseases, 1994-07, Vol.38 (3), p.435-445</ispartof><rights>Copyright 1994 The American Association of Avian Pathologists, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c324t-8377f43d50f421b446e08071000e005199116ed5077826a140fa6902a175d6023</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1592063$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1592063$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>315,781,785,804,27929,27930,58022,58255</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7832695$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Westerhof, I. (Utrecht University, Utrecht, The Netherlands)</creatorcontrib><creatorcontrib>Brom, W.E. van den</creatorcontrib><creatorcontrib>Mol, J.A</creatorcontrib><creatorcontrib>Lumeij, J.T</creatorcontrib><creatorcontrib>Rijnberk, A</creatorcontrib><title>Sensitivity of the hypothalamic-pituitary-adrenal system of pigeons (Columbia livia domestica) to suppression by dexamethasone, cortisol, and prednisolone</title><title>Avian diseases</title><addtitle>Avian Dis</addtitle><description>The sensitivity of the hypothalamic-pituitary-adrenal system in pigeons (Columba livia domestica) to glucocorticoid feedback was studied after single intravenous administration of dexamethasone (500, 100, 50, 10, 5, 1, 0.5, and 0.1 microgram/kg), cortisol (15,000, 3000, 1500, 300, 150, 30, 15, and 3 microgram/kg), and prednisolone (3500, 700, 350, 70, 35, 7, 3.5, 0.7, and 0.35 microgram/kg). Dose responses, the threshold doses, and the onset of maximum suppression were determined by measuring plasma corticosterone concentrations around the expected peak of plasma corticosterone in pigeons kept on a shifted-light regimen. At 52 hr following the highest dose of dexamethasone, and at 48 hr following the highest doses of cortisol and prednisolone, plasma corticosterone concentrations were similar to the initial values and to the control values. Following the minimum doses that resulted in suppression of the normal diurnal variation in plasma corticosterone concentration (0.5 microgram dexamethasone/kg, 15 microgram cortisol/kg, and 0.7 microgram prednisolone/kg), plasma corticosterone concentrations were similar to values of the control group and to initial values within 24 hr. The onset of suppression of plasma corticosterone concentrations was between 30 and 60 min following 1 microgram dexamethasone/kg, 7 microgram prednisolone/kg, or 30 microgram cortisol/kg. Suppression was greatest at 60 min following prednisolone and cortisol administration, and at 90 min following dexamethasone administration. It is concluded that the hypothalamic-pituitary-adrenal system of pigeons reacts to exogenous glucocorticoids by early delayed feedback, is more sensitive to suppression by glucocorticoids than that of mammals, and is suppressed for the longest time by dexamethasone. These observations indicate that some of the side effects of glucocorticoid therapy are likely to be at least as frequent and as severe in birds as in mammals</description><subject>Animals</subject><subject>Birds</subject><subject>Blood plasma</subject><subject>CEREBRO</subject><subject>Circadian Rhythm - physiology</subject><subject>Columbidae - physiology</subject><subject>Control groups</subject><subject>Corticosterone</subject><subject>DEXAMETHASONE</subject><subject>Dexamethasone - administration & dosage</subject><subject>Dexamethasone - pharmacology</subject><subject>Dose response relationship</subject><subject>ENCEPHALE</subject><subject>Environment, Controlled</subject><subject>ESTEROIDES</subject><subject>Feedback</subject><subject>Female</subject><subject>GLANDULA PITUITARIA</subject><subject>GLANDULAS SUPRARRENALES</subject><subject>GLUCOCORTICOIDE</subject><subject>GLUCOCORTICOIDES</subject><subject>Glucocorticoids</subject><subject>Human resources</subject><subject>Hydrocortisone - administration & dosage</subject><subject>Hydrocortisone - pharmacology</subject><subject>HYPOPHYSE</subject><subject>Hypothalamo-Hypophyseal System - drug effects</subject><subject>Hypothalamo-Hypophyseal System - physiology</subject><subject>INJECTION</subject><subject>Intravenous injections</subject><subject>INYECCION</subject><subject>Light</subject><subject>Male</subject><subject>Mammals</subject><subject>PALOMA</subject><subject>PIGEON</subject><subject>Pigeons</subject><subject>Pituitary-Adrenal System - drug effects</subject><subject>Pituitary-Adrenal System - physiology</subject><subject>Prednisolone - administration & dosage</subject><subject>Prednisolone - pharmacology</subject><subject>RITMOS BIOLOGICOS</subject><subject>RYTHME BIOLOGIQUE</subject><subject>STEROIDE</subject><subject>SURRENALE</subject><issn>0005-2086</issn><issn>1938-4351</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1r3DAQhkVpSLdpyb1Q0KG0CcTNSLIl-1iW5gMCPaQ5G609zirYlquRQ_1X8murZZcecxrE--hhPhg7FfBdKjCXoqgkaPWGrUSlyixXhXjLVgBQZBJK_Y69J3oCEKbScMyOTamkrooVe7nHkVx0zy4u3Hc8bpFvl8nHre3t4JpscnF20YYls23A0facFoo47ODJPaIfiZ-tfT8PG2d5n0SWt35Aiq6x5zx6TvM0BSRyfuSbhbf41w6Y_ORHvOCND9GR7y-4HVuewHbcPVP2gR11tif8eKgn7OHq5-_1TXb36_p2_eMua5TMY1YqY7pctQV0uRSbPNcIJRiRZsc0vqgqITSm2JhSaity6KyuQFphilaDVCfs6947Bf9nTo3Xg6MG-96O6GeqjTGi1EIk8NsebIInCtjVU3BDWk0toN5doT5cIZGfD8p5M2D7nzusPeVf9vkTRR9e0XzaY531tX0MjuqH-_Rd5apU_wDGhpaF</recordid><startdate>19940701</startdate><enddate>19940701</enddate><creator>Westerhof, I. (Utrecht University, Utrecht, The Netherlands)</creator><creator>Brom, W.E. van den</creator><creator>Mol, J.A</creator><creator>Lumeij, J.T</creator><creator>Rijnberk, A</creator><general>American Association of Avian Pathologists, Inc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19940701</creationdate><title>Sensitivity of the hypothalamic-pituitary-adrenal system of pigeons (Columbia livia domestica) to suppression by dexamethasone, cortisol, and prednisolone</title><author>Westerhof, I. (Utrecht University, Utrecht, The Netherlands) ; Brom, W.E. van den ; Mol, J.A ; Lumeij, J.T ; Rijnberk, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c324t-8377f43d50f421b446e08071000e005199116ed5077826a140fa6902a175d6023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Birds</topic><topic>Blood plasma</topic><topic>CEREBRO</topic><topic>Circadian Rhythm - physiology</topic><topic>Columbidae - physiology</topic><topic>Control groups</topic><topic>Corticosterone</topic><topic>DEXAMETHASONE</topic><topic>Dexamethasone - administration & dosage</topic><topic>Dexamethasone - pharmacology</topic><topic>Dose response relationship</topic><topic>ENCEPHALE</topic><topic>Environment, Controlled</topic><topic>ESTEROIDES</topic><topic>Feedback</topic><topic>Female</topic><topic>GLANDULA PITUITARIA</topic><topic>GLANDULAS SUPRARRENALES</topic><topic>GLUCOCORTICOIDE</topic><topic>GLUCOCORTICOIDES</topic><topic>Glucocorticoids</topic><topic>Human resources</topic><topic>Hydrocortisone - administration & dosage</topic><topic>Hydrocortisone - pharmacology</topic><topic>HYPOPHYSE</topic><topic>Hypothalamo-Hypophyseal System - drug effects</topic><topic>Hypothalamo-Hypophyseal System - physiology</topic><topic>INJECTION</topic><topic>Intravenous injections</topic><topic>INYECCION</topic><topic>Light</topic><topic>Male</topic><topic>Mammals</topic><topic>PALOMA</topic><topic>PIGEON</topic><topic>Pigeons</topic><topic>Pituitary-Adrenal System - drug effects</topic><topic>Pituitary-Adrenal System - physiology</topic><topic>Prednisolone - administration & dosage</topic><topic>Prednisolone - pharmacology</topic><topic>RITMOS BIOLOGICOS</topic><topic>RYTHME BIOLOGIQUE</topic><topic>STEROIDE</topic><topic>SURRENALE</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Westerhof, I. (Utrecht University, Utrecht, The Netherlands)</creatorcontrib><creatorcontrib>Brom, W.E. van den</creatorcontrib><creatorcontrib>Mol, J.A</creatorcontrib><creatorcontrib>Lumeij, J.T</creatorcontrib><creatorcontrib>Rijnberk, A</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Avian diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Westerhof, I. (Utrecht University, Utrecht, The Netherlands)</au><au>Brom, W.E. van den</au><au>Mol, J.A</au><au>Lumeij, J.T</au><au>Rijnberk, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sensitivity of the hypothalamic-pituitary-adrenal system of pigeons (Columbia livia domestica) to suppression by dexamethasone, cortisol, and prednisolone</atitle><jtitle>Avian diseases</jtitle><addtitle>Avian Dis</addtitle><date>1994-07-01</date><risdate>1994</risdate><volume>38</volume><issue>3</issue><spage>435</spage><epage>445</epage><pages>435-445</pages><issn>0005-2086</issn><eissn>1938-4351</eissn><abstract>The sensitivity of the hypothalamic-pituitary-adrenal system in pigeons (Columba livia domestica) to glucocorticoid feedback was studied after single intravenous administration of dexamethasone (500, 100, 50, 10, 5, 1, 0.5, and 0.1 microgram/kg), cortisol (15,000, 3000, 1500, 300, 150, 30, 15, and 3 microgram/kg), and prednisolone (3500, 700, 350, 70, 35, 7, 3.5, 0.7, and 0.35 microgram/kg). Dose responses, the threshold doses, and the onset of maximum suppression were determined by measuring plasma corticosterone concentrations around the expected peak of plasma corticosterone in pigeons kept on a shifted-light regimen. At 52 hr following the highest dose of dexamethasone, and at 48 hr following the highest doses of cortisol and prednisolone, plasma corticosterone concentrations were similar to the initial values and to the control values. Following the minimum doses that resulted in suppression of the normal diurnal variation in plasma corticosterone concentration (0.5 microgram dexamethasone/kg, 15 microgram cortisol/kg, and 0.7 microgram prednisolone/kg), plasma corticosterone concentrations were similar to values of the control group and to initial values within 24 hr. The onset of suppression of plasma corticosterone concentrations was between 30 and 60 min following 1 microgram dexamethasone/kg, 7 microgram prednisolone/kg, or 30 microgram cortisol/kg. Suppression was greatest at 60 min following prednisolone and cortisol administration, and at 90 min following dexamethasone administration. It is concluded that the hypothalamic-pituitary-adrenal system of pigeons reacts to exogenous glucocorticoids by early delayed feedback, is more sensitive to suppression by glucocorticoids than that of mammals, and is suppressed for the longest time by dexamethasone. These observations indicate that some of the side effects of glucocorticoid therapy are likely to be at least as frequent and as severe in birds as in mammals</abstract><cop>United States</cop><pub>American Association of Avian Pathologists, Inc</pub><pmid>7832695</pmid><doi>10.2307/1592063</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0005-2086 |
| ispartof | Avian diseases, 1994-07, Vol.38 (3), p.435-445 |
| issn | 0005-2086 1938-4351 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77718611 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing |
| subjects | Animals Birds Blood plasma CEREBRO Circadian Rhythm - physiology Columbidae - physiology Control groups Corticosterone DEXAMETHASONE Dexamethasone - administration & dosage Dexamethasone - pharmacology Dose response relationship ENCEPHALE Environment, Controlled ESTEROIDES Feedback Female GLANDULA PITUITARIA GLANDULAS SUPRARRENALES GLUCOCORTICOIDE GLUCOCORTICOIDES Glucocorticoids Human resources Hydrocortisone - administration & dosage Hydrocortisone - pharmacology HYPOPHYSE Hypothalamo-Hypophyseal System - drug effects Hypothalamo-Hypophyseal System - physiology INJECTION Intravenous injections INYECCION Light Male Mammals PALOMA PIGEON Pigeons Pituitary-Adrenal System - drug effects Pituitary-Adrenal System - physiology Prednisolone - administration & dosage Prednisolone - pharmacology RITMOS BIOLOGICOS RYTHME BIOLOGIQUE STEROIDE SURRENALE |
| title | Sensitivity of the hypothalamic-pituitary-adrenal system of pigeons (Columbia livia domestica) to suppression by dexamethasone, cortisol, and prednisolone |
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