Decontamination studies with the agents of bovine spongiform encephalopathy and scrapie
Macerates of bovine brain infected with bovine spongiform encephalopathy (BSE) agent, and rodent brain infected with the 263K or ME7 strains of scrapie agent, were subjected to porous-load autoclaving at temperatures between 134 and 138 degrees C for < 60 min. Bioassay in rodents showed that none...
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| Veröffentlicht in: | Archives of virology 1994-01, Vol.139 (3/4), p.313-326 |
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| container_title | Archives of virology |
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| creator | Taylor, D.M Fraser, H McConnell, I Brown, D.A Brown, K.L Lamza, K.A Smith, G.R.A |
| description | Macerates of bovine brain infected with bovine spongiform encephalopathy (BSE) agent, and rodent brain infected with the 263K or ME7 strains of scrapie agent, were subjected to porous-load autoclaving at temperatures between 134 and 138 degrees C for < 60 min. Bioassay in rodents showed that none of the regimes produced complete inactivation. Homogenates Of BSE-infected bovine brain were exposed for < 120 min to solutions of sodium hypochlorite or sodium dichloroisocyanurate containing < 16,500 ppm available chlorine. There was no detectable survival of infectivity after the hypochlorite treatments but none of the dichloroisocyanurate solutions produced complete inactivation. Homogenates of BSE-infected bovine brain, and rodent brain infected with the 263K and ME7 strains of scrapie agent, were exposed for < 120 min to 1 M or 2 M sodium hydroxide but no procedure produced complete inactivation of all agents tested. |
| doi_str_mv | 10.1007/BF01310794 |
| format | Article |
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Bioassay in rodents showed that none of the regimes produced complete inactivation. Homogenates Of BSE-infected bovine brain were exposed for < 120 min to solutions of sodium hypochlorite or sodium dichloroisocyanurate containing < 16,500 ppm available chlorine. There was no detectable survival of infectivity after the hypochlorite treatments but none of the dichloroisocyanurate solutions produced complete inactivation. Homogenates of BSE-infected bovine brain, and rodent brain infected with the 263K and ME7 strains of scrapie agent, were exposed for < 120 min to 1 M or 2 M sodium hydroxide but no procedure produced complete inactivation of all agents tested.</description><identifier>ISSN: 0304-8608</identifier><identifier>EISSN: 1432-8798</identifier><identifier>DOI: 10.1007/BF01310794</identifier><identifier>PMID: 7832638</identifier><language>eng</language><publisher>Wien: Springer</publisher><subject>Animals ; autoclaving ; bioassays ; Biological and medical sciences ; bovine spongiform encephalopathy ; Cattle ; chlorine ; Disinfection ; Encephalopathy, Bovine Spongiform - virology ; Hot Temperature ; Human viral diseases ; Infectious diseases ; Medical sciences ; Mice ; Mice, Inbred C57BL ; pathogenicity ; PrPSc proteins ; PrPSc Proteins - pathogenicity ; Scrapie - virology ; sodium dichloroisocyanurate ; Sodium Hydroxide - pharmacology ; sodium hydroxide treatment ; sodium hypochlorite ; Sodium Hypochlorite - pharmacology ; Triazines - pharmacology ; Viral diseases ; Viral diseases of the nervous system</subject><ispartof>Archives of virology, 1994-01, Vol.139 (3/4), p.313-326</ispartof><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c366t-495661ab0ffcb851568b7b053116588816807d97373519cb92070346f9251b113</citedby><cites>FETCH-LOGICAL-c366t-495661ab0ffcb851568b7b053116588816807d97373519cb92070346f9251b113</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3360704$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7832638$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Taylor, D.M</creatorcontrib><creatorcontrib>Fraser, H</creatorcontrib><creatorcontrib>McConnell, I</creatorcontrib><creatorcontrib>Brown, D.A</creatorcontrib><creatorcontrib>Brown, K.L</creatorcontrib><creatorcontrib>Lamza, K.A</creatorcontrib><creatorcontrib>Smith, G.R.A</creatorcontrib><title>Decontamination studies with the agents of bovine spongiform encephalopathy and scrapie</title><title>Archives of virology</title><addtitle>Arch Virol</addtitle><description>Macerates of bovine brain infected with bovine spongiform encephalopathy (BSE) agent, and rodent brain infected with the 263K or ME7 strains of scrapie agent, were subjected to porous-load autoclaving at temperatures between 134 and 138 degrees C for < 60 min. Bioassay in rodents showed that none of the regimes produced complete inactivation. Homogenates Of BSE-infected bovine brain were exposed for < 120 min to solutions of sodium hypochlorite or sodium dichloroisocyanurate containing < 16,500 ppm available chlorine. There was no detectable survival of infectivity after the hypochlorite treatments but none of the dichloroisocyanurate solutions produced complete inactivation. Homogenates of BSE-infected bovine brain, and rodent brain infected with the 263K and ME7 strains of scrapie agent, were exposed for < 120 min to 1 M or 2 M sodium hydroxide but no procedure produced complete inactivation of all agents tested.</description><subject>Animals</subject><subject>autoclaving</subject><subject>bioassays</subject><subject>Biological and medical sciences</subject><subject>bovine spongiform encephalopathy</subject><subject>Cattle</subject><subject>chlorine</subject><subject>Disinfection</subject><subject>Encephalopathy, Bovine Spongiform - virology</subject><subject>Hot Temperature</subject><subject>Human viral diseases</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>pathogenicity</subject><subject>PrPSc proteins</subject><subject>PrPSc Proteins - pathogenicity</subject><subject>Scrapie - virology</subject><subject>sodium dichloroisocyanurate</subject><subject>Sodium Hydroxide - pharmacology</subject><subject>sodium hydroxide treatment</subject><subject>sodium hypochlorite</subject><subject>Sodium Hypochlorite - pharmacology</subject><subject>Triazines - pharmacology</subject><subject>Viral diseases</subject><subject>Viral diseases of the nervous system</subject><issn>0304-8608</issn><issn>1432-8798</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0E1P3DAQBmALtYIt5cId1QfUA1LamTj-yJHPthJSD4A4Ro7X3jVK7NT2FvHvCdoVPfZkaebRO_JLyDHCNwSQ3y9uABmCbJs9ssCG1ZWSrfpAFsCgqZQAdUA-5fwEMA8Y3yf7UrFaMLUgj1fWxFD06IMuPgaay2bpbabPvqxpWVuqVzaUTKOjffzrg6V5imHlXUwjtcHYaa2HOOmyfqE6LGk2SU_efiYfnR6yPdq9h-Th5vr-8md1-_vHr8vz28owIUrVtFwI1D04Z3rFkQvVyx44QxRcKYVCgVy2kknGsTV9W4ME1gjX1hx7RHZIvm5zpxT_bGwu3eizscOgg42b3EkpUfGa_ReihPm4ghmebaFJMedkXTclP-r00iF0b3V3_-qe8ckuddOPdvlOd_3O-9PdXmejB5d0MD6_M8bE_J-3mC9b5nTs9CrN5OGunq8AcqiVkuwVDuOOMg</recordid><startdate>19940101</startdate><enddate>19940101</enddate><creator>Taylor, D.M</creator><creator>Fraser, H</creator><creator>McConnell, I</creator><creator>Brown, D.A</creator><creator>Brown, K.L</creator><creator>Lamza, K.A</creator><creator>Smith, G.R.A</creator><general>Springer</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19940101</creationdate><title>Decontamination studies with the agents of bovine spongiform encephalopathy and scrapie</title><author>Taylor, D.M ; Fraser, H ; McConnell, I ; Brown, D.A ; Brown, K.L ; Lamza, K.A ; Smith, G.R.A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c366t-495661ab0ffcb851568b7b053116588816807d97373519cb92070346f9251b113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>autoclaving</topic><topic>bioassays</topic><topic>Biological and medical sciences</topic><topic>bovine spongiform encephalopathy</topic><topic>Cattle</topic><topic>chlorine</topic><topic>Disinfection</topic><topic>Encephalopathy, Bovine Spongiform - virology</topic><topic>Hot Temperature</topic><topic>Human viral diseases</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>pathogenicity</topic><topic>PrPSc proteins</topic><topic>PrPSc Proteins - pathogenicity</topic><topic>Scrapie - virology</topic><topic>sodium dichloroisocyanurate</topic><topic>Sodium Hydroxide - pharmacology</topic><topic>sodium hydroxide treatment</topic><topic>sodium hypochlorite</topic><topic>Sodium Hypochlorite - pharmacology</topic><topic>Triazines - pharmacology</topic><topic>Viral diseases</topic><topic>Viral diseases of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Taylor, D.M</creatorcontrib><creatorcontrib>Fraser, H</creatorcontrib><creatorcontrib>McConnell, I</creatorcontrib><creatorcontrib>Brown, D.A</creatorcontrib><creatorcontrib>Brown, K.L</creatorcontrib><creatorcontrib>Lamza, K.A</creatorcontrib><creatorcontrib>Smith, G.R.A</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Taylor, D.M</au><au>Fraser, H</au><au>McConnell, I</au><au>Brown, D.A</au><au>Brown, K.L</au><au>Lamza, K.A</au><au>Smith, G.R.A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decontamination studies with the agents of bovine spongiform encephalopathy and scrapie</atitle><jtitle>Archives of virology</jtitle><addtitle>Arch Virol</addtitle><date>1994-01-01</date><risdate>1994</risdate><volume>139</volume><issue>3/4</issue><spage>313</spage><epage>326</epage><pages>313-326</pages><issn>0304-8608</issn><eissn>1432-8798</eissn><abstract>Macerates of bovine brain infected with bovine spongiform encephalopathy (BSE) agent, and rodent brain infected with the 263K or ME7 strains of scrapie agent, were subjected to porous-load autoclaving at temperatures between 134 and 138 degrees C for < 60 min. Bioassay in rodents showed that none of the regimes produced complete inactivation. Homogenates Of BSE-infected bovine brain were exposed for < 120 min to solutions of sodium hypochlorite or sodium dichloroisocyanurate containing < 16,500 ppm available chlorine. There was no detectable survival of infectivity after the hypochlorite treatments but none of the dichloroisocyanurate solutions produced complete inactivation. Homogenates of BSE-infected bovine brain, and rodent brain infected with the 263K and ME7 strains of scrapie agent, were exposed for < 120 min to 1 M or 2 M sodium hydroxide but no procedure produced complete inactivation of all agents tested.</abstract><cop>Wien</cop><cop>New York, NY</cop><pub>Springer</pub><pmid>7832638</pmid><doi>10.1007/BF01310794</doi><tpages>14</tpages></addata></record> |
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| ispartof | Archives of virology, 1994-01, Vol.139 (3/4), p.313-326 |
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| subjects | Animals autoclaving bioassays Biological and medical sciences bovine spongiform encephalopathy Cattle chlorine Disinfection Encephalopathy, Bovine Spongiform - virology Hot Temperature Human viral diseases Infectious diseases Medical sciences Mice Mice, Inbred C57BL pathogenicity PrPSc proteins PrPSc Proteins - pathogenicity Scrapie - virology sodium dichloroisocyanurate Sodium Hydroxide - pharmacology sodium hydroxide treatment sodium hypochlorite Sodium Hypochlorite - pharmacology Triazines - pharmacology Viral diseases Viral diseases of the nervous system |
| title | Decontamination studies with the agents of bovine spongiform encephalopathy and scrapie |
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