BIOXALOMYCINS, NEW ANTIBIOTICS PRODUCED BY THE MARINE Streptomyces sp. LL-31F508: TAXONOMY AND FERMENTATION
An actinomycete strain designated LL-31F508 was isolated from an intertidal sediment sample collected in Key West, Florida. Culture LL-31F508 was assigned to the Streptomyces genus based on the presence of LL-diaminopimelic acid (DAP) in the cell wall and observations of spiny spores using scanning...
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| Veröffentlicht in: | Journal of antibiotics 1994/12/25, Vol.47(12), pp.1417-1424 |
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| container_issue | 12 |
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| container_title | Journal of antibiotics |
| container_volume | 47 |
| creator | BERNAN, VERNAN S. MONTENEGRO, DEBORAH A. KORSHALLA, JOSEPH D. MAIESE, WILLIAM M. STEINBERG, DEBORAH A. GREENSTEIN, MICHAEL |
| description | An actinomycete strain designated LL-31F508 was isolated from an intertidal sediment sample collected in Key West, Florida. Culture LL-31F508 was assigned to the Streptomyces genus based on the presence of LL-diaminopimelic acid (DAP) in the cell wall and observations of spiny spores using scanning electron microscopy (SEM). Excellent antimicrobial activity against Staphyloccoccus and Enterococcus spp. were detected in both the supernatant and cell extract samples from fermentations of culture LL-31F508. Production of antibiotic activity peaked at 48-50 hours and closely paralleled cell growth, during which time glucose was more rapidly assimilated than dextrin. A series of new antibiotics called the bioxalomycins was identified as the antibacterial products from fermentations of this culture. Fermentation conditions for production of bioxalomycin α differed substantially from those required for production of a related compound, naphthyridinomycin, by the reference culture Streptomyces lusitanus NRRL 8034. |
| doi_str_mv | 10.7164/antibiotics.47.1417 |
| format | Article |
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LL-31F508: TAXONOMY AND FERMENTATION</title><source>J-STAGE Free</source><source>MEDLINE</source><creator>BERNAN, VERNAN S. ; MONTENEGRO, DEBORAH A. ; KORSHALLA, JOSEPH D. ; MAIESE, WILLIAM M. ; STEINBERG, DEBORAH A. ; GREENSTEIN, MICHAEL</creator><creatorcontrib>BERNAN, VERNAN S. ; MONTENEGRO, DEBORAH A. ; KORSHALLA, JOSEPH D. ; MAIESE, WILLIAM M. ; STEINBERG, DEBORAH A. ; GREENSTEIN, MICHAEL</creatorcontrib><description>An actinomycete strain designated LL-31F508 was isolated from an intertidal sediment sample collected in Key West, Florida. Culture LL-31F508 was assigned to the Streptomyces genus based on the presence of LL-diaminopimelic acid (DAP) in the cell wall and observations of spiny spores using scanning electron microscopy (SEM). Excellent antimicrobial activity against Staphyloccoccus and Enterococcus spp. were detected in both the supernatant and cell extract samples from fermentations of culture LL-31F508. Production of antibiotic activity peaked at 48-50 hours and closely paralleled cell growth, during which time glucose was more rapidly assimilated than dextrin. A series of new antibiotics called the bioxalomycins was identified as the antibacterial products from fermentations of this culture. Fermentation conditions for production of bioxalomycin α differed substantially from those required for production of a related compound, naphthyridinomycin, by the reference culture Streptomyces lusitanus NRRL 8034.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.7164/antibiotics.47.1417</identifier><identifier>PMID: 7844035</identifier><language>eng</language><publisher>Japan: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</publisher><subject>Anti-Bacterial Agents - biosynthesis ; Anti-Bacterial Agents - pharmacology ; Enterococcus ; Fermentation ; Gram-Positive Bacteria - drug effects ; Microbial Sensitivity Tests ; Microscopy, Electron, Scanning ; Oxazoles - isolation & purification ; Oxazoles - pharmacology ; Staphylococcus ; Streptomyces - classification ; Streptomyces - metabolism ; Streptomyces - ultrastructure</subject><ispartof>The Journal of Antibiotics, 1994/12/25, Vol.47(12), pp.1417-1424</ispartof><rights>Japan Antibiotics Research Association</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c614t-47a1e5c58893cc2781b37939d181848492e5814dfa9dc65b0b63711cc34983793</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1881,4014,27914,27915,27916</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7844035$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BERNAN, VERNAN S.</creatorcontrib><creatorcontrib>MONTENEGRO, DEBORAH A.</creatorcontrib><creatorcontrib>KORSHALLA, JOSEPH D.</creatorcontrib><creatorcontrib>MAIESE, WILLIAM M.</creatorcontrib><creatorcontrib>STEINBERG, DEBORAH A.</creatorcontrib><creatorcontrib>GREENSTEIN, MICHAEL</creatorcontrib><title>BIOXALOMYCINS, NEW ANTIBIOTICS PRODUCED BY THE MARINE Streptomyces sp. LL-31F508: TAXONOMY AND FERMENTATION</title><title>Journal of antibiotics</title><addtitle>J. Antibiot.</addtitle><description>An actinomycete strain designated LL-31F508 was isolated from an intertidal sediment sample collected in Key West, Florida. Culture LL-31F508 was assigned to the Streptomyces genus based on the presence of LL-diaminopimelic acid (DAP) in the cell wall and observations of spiny spores using scanning electron microscopy (SEM). Excellent antimicrobial activity against Staphyloccoccus and Enterococcus spp. were detected in both the supernatant and cell extract samples from fermentations of culture LL-31F508. Production of antibiotic activity peaked at 48-50 hours and closely paralleled cell growth, during which time glucose was more rapidly assimilated than dextrin. A series of new antibiotics called the bioxalomycins was identified as the antibacterial products from fermentations of this culture. Fermentation conditions for production of bioxalomycin α differed substantially from those required for production of a related compound, naphthyridinomycin, by the reference culture Streptomyces lusitanus NRRL 8034.</description><subject>Anti-Bacterial Agents - biosynthesis</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Enterococcus</subject><subject>Fermentation</subject><subject>Gram-Positive Bacteria - drug effects</subject><subject>Microbial Sensitivity Tests</subject><subject>Microscopy, Electron, Scanning</subject><subject>Oxazoles - isolation & purification</subject><subject>Oxazoles - pharmacology</subject><subject>Staphylococcus</subject><subject>Streptomyces - classification</subject><subject>Streptomyces - metabolism</subject><subject>Streptomyces - ultrastructure</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFvmzAYhq1qU5d2_QXTJJ92Kpk_bPDHbpSQFYnAlFCtPVnGcTa6JKSYHPrvR5Yo6m0XW_L7fI-l7yXkE7CxhFB81du-qZu2b4wbCzkGAfKCjAARPBBh9I6MGPPBQ_TZB3Ll3DNjXHKJl-RSohCMByPy5y4rH-O8nD0lWbG4pUX6k8ZFlQ3PVZYs6I95OXlI0gm9e6LVfUpn8TwrUrroO7vr282rsY663ZjmucdhGjD8Rqv4sSwG4eCZ0Gk6n6VFFVdZWXwk71d67ezN6b4mD9O0Su69vPyeJXHumRBE7wmpwQYmQIy4Mb5EqLmMeLQEBBQoIt8GCGK50tHShEHN6pBLAGO4iPBAXpMvR--ua1_21vVq0zhj12u9te3eKSmH9QH-H4RQCskCfwD5ETRd61xnV2rXNRvdvSpg6tCFetOFElIduhimPp_0-3pjl-eZ0_KHvDjmz67Xv-w5192gWdu3TohC_Of1T-fhgzNofutO2S3_C0Immxk</recordid><startdate>1994</startdate><enddate>1994</enddate><creator>BERNAN, VERNAN S.</creator><creator>MONTENEGRO, DEBORAH A.</creator><creator>KORSHALLA, JOSEPH D.</creator><creator>MAIESE, WILLIAM M.</creator><creator>STEINBERG, DEBORAH A.</creator><creator>GREENSTEIN, MICHAEL</creator><general>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>F1W</scope><scope>FR3</scope><scope>H95</scope><scope>H99</scope><scope>L.F</scope><scope>L.G</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>1994</creationdate><title>BIOXALOMYCINS, NEW ANTIBIOTICS PRODUCED BY THE MARINE Streptomyces sp. LL-31F508: TAXONOMY AND FERMENTATION</title><author>BERNAN, VERNAN S. ; MONTENEGRO, DEBORAH A. ; KORSHALLA, JOSEPH D. ; MAIESE, WILLIAM M. ; STEINBERG, DEBORAH A. ; GREENSTEIN, MICHAEL</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c614t-47a1e5c58893cc2781b37939d181848492e5814dfa9dc65b0b63711cc34983793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Anti-Bacterial Agents - biosynthesis</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Enterococcus</topic><topic>Fermentation</topic><topic>Gram-Positive Bacteria - drug effects</topic><topic>Microbial Sensitivity Tests</topic><topic>Microscopy, Electron, Scanning</topic><topic>Oxazoles - isolation & purification</topic><topic>Oxazoles - pharmacology</topic><topic>Staphylococcus</topic><topic>Streptomyces - classification</topic><topic>Streptomyces - metabolism</topic><topic>Streptomyces - ultrastructure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BERNAN, VERNAN S.</creatorcontrib><creatorcontrib>MONTENEGRO, DEBORAH A.</creatorcontrib><creatorcontrib>KORSHALLA, JOSEPH D.</creatorcontrib><creatorcontrib>MAIESE, WILLIAM M.</creatorcontrib><creatorcontrib>STEINBERG, DEBORAH A.</creatorcontrib><creatorcontrib>GREENSTEIN, MICHAEL</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>ASFA: Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BERNAN, VERNAN S.</au><au>MONTENEGRO, DEBORAH A.</au><au>KORSHALLA, JOSEPH D.</au><au>MAIESE, WILLIAM M.</au><au>STEINBERG, DEBORAH A.</au><au>GREENSTEIN, MICHAEL</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>BIOXALOMYCINS, NEW ANTIBIOTICS PRODUCED BY THE MARINE Streptomyces sp. LL-31F508: TAXONOMY AND FERMENTATION</atitle><jtitle>Journal of antibiotics</jtitle><addtitle>J. Antibiot.</addtitle><date>1994</date><risdate>1994</risdate><volume>47</volume><issue>12</issue><spage>1417</spage><epage>1424</epage><pages>1417-1424</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><abstract>An actinomycete strain designated LL-31F508 was isolated from an intertidal sediment sample collected in Key West, Florida. Culture LL-31F508 was assigned to the Streptomyces genus based on the presence of LL-diaminopimelic acid (DAP) in the cell wall and observations of spiny spores using scanning electron microscopy (SEM). Excellent antimicrobial activity against Staphyloccoccus and Enterococcus spp. were detected in both the supernatant and cell extract samples from fermentations of culture LL-31F508. Production of antibiotic activity peaked at 48-50 hours and closely paralleled cell growth, during which time glucose was more rapidly assimilated than dextrin. 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| ispartof | The Journal of Antibiotics, 1994/12/25, Vol.47(12), pp.1417-1424 |
| issn | 0021-8820 1881-1469 |
| language | eng |
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| subjects | Anti-Bacterial Agents - biosynthesis Anti-Bacterial Agents - pharmacology Enterococcus Fermentation Gram-Positive Bacteria - drug effects Microbial Sensitivity Tests Microscopy, Electron, Scanning Oxazoles - isolation & purification Oxazoles - pharmacology Staphylococcus Streptomyces - classification Streptomyces - metabolism Streptomyces - ultrastructure |
| title | BIOXALOMYCINS, NEW ANTIBIOTICS PRODUCED BY THE MARINE Streptomyces sp. LL-31F508: TAXONOMY AND FERMENTATION |
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