Selective blockade of the hyperpolarization-activated cationic current ( Ih) in guinea pig substantia nigra pars compacta neurones by a novel bradycardic agent, Zeneca ZM 227189

The effects of a novel bradycardic agent Zeneca ZM 227189 (4-( N-ethyl- N-phenylamino)-1,2-dimethyl-6-(methylamino) triazinium iodide) were tested on the inward rectifying properties of guinea-pig substantia nigra pars compacta (SNC) and guinea-pig olfactory cortical cells recorded in vitro. In SNC...

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Veröffentlicht in:	Neuroscience letters 1994-08, Vol.176 (2), p.221-225
Hauptverfasser:	Harris, N.C., Libri, V., Constanti, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aniline Compounds - pharmacology Animals Biological and medical sciences Cardiotonic Agents - pharmacology Central nervous system Cesium - pharmacology Electrophysiology Fast inward rectification Fundamental and applied biological sciences. Psychology Guinea Pigs Guinea-pig olfactory cortex Guinea-pig substantia nigra Hyperpolarization-activated current In Vitro Techniques Intracellular recording Ion Channels - drug effects Ion Channels - metabolism Membrane Potentials - drug effects Neurons - drug effects Neurons - metabolism Olfactory Pathways - cytology Olfactory Pathways - drug effects Olfactory Pathways - metabolism Patch-Clamp Techniques Specific bradycardic agent ZM 227189 Substantia Nigra - cytology Substantia Nigra - drug effects Substantia Nigra - metabolism Triazoles - pharmacology Vertebrates: nervous system and sense organs
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