Modulation of the vestibulo-ocular reflex by serotonin in the rat
The effects of intraventricular injection of serotonin (5-HT) and its agonists and antagonists on the amplitude of the vestibulo-ocular reflex were studied in chronic implanted rats. 5-HT (10(-5) M) triggers an increase of the amplitude of the reflex which lasts 30 min. Similar results are obtained...
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| Veröffentlicht in: | Pflügers Archiv 1987-08, Vol.409 (4-5), p.507-511 |
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| creator | TERNAUX, J.-P GAMBARELLI, F |
| description | The effects of intraventricular injection of serotonin (5-HT) and its agonists and antagonists on the amplitude of the vestibulo-ocular reflex were studied in chronic implanted rats. 5-HT (10(-5) M) triggers an increase of the amplitude of the reflex which lasts 30 min. Similar results are obtained when N,N-dimethyl-5-methoxytryptamine (10(-3) M) is introduced into the ventricular cannula. The increasing effects observed both with 5-HT and N,N-dimethyl-5-methoxy-tryptamine are abolished by methiothepin, a potent antagonist of 5-HT receptors. Injection of indirect agonists like pargyline, a monoamine oxidase inhibitor, or fluoxetine, a potent inhibitor of 5-HT reuptake, is followed by an increase of the amplitude of the vestibulo-ocular reflex. These results indicate that 5-HT can modulate the activity of the vestibulo-ocular pathway and muscular tone of extraocular muscles. Location and involvement of various modulating 5-HT sites are discussed. |
| doi_str_mv | 10.1007/BF00583808 |
| format | Article |
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Similar results are obtained when N,N-dimethyl-5-methoxytryptamine (10(-3) M) is introduced into the ventricular cannula. The increasing effects observed both with 5-HT and N,N-dimethyl-5-methoxy-tryptamine are abolished by methiothepin, a potent antagonist of 5-HT receptors. Injection of indirect agonists like pargyline, a monoamine oxidase inhibitor, or fluoxetine, a potent inhibitor of 5-HT reuptake, is followed by an increase of the amplitude of the vestibulo-ocular reflex. These results indicate that 5-HT can modulate the activity of the vestibulo-ocular pathway and muscular tone of extraocular muscles. Location and involvement of various modulating 5-HT sites are discussed.</description><identifier>ISSN: 0031-6768</identifier><identifier>EISSN: 1432-2013</identifier><identifier>DOI: 10.1007/BF00583808</identifier><identifier>PMID: 3627966</identifier><identifier>CODEN: PFLABK</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Animals ; Biological and medical sciences ; Electric Stimulation ; Fundamental and applied biological sciences. Psychology ; Injections, Intraventricular ; Male ; Methiothepin - pharmacology ; Methoxydimethyltryptamines - pharmacology ; Rats ; Rats, Inbred Strains ; Reflex, Vestibulo-Ocular - drug effects ; Serotonin - administration & dosage ; Serotonin - pharmacology ; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. 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Similar results are obtained when N,N-dimethyl-5-methoxytryptamine (10(-3) M) is introduced into the ventricular cannula. The increasing effects observed both with 5-HT and N,N-dimethyl-5-methoxy-tryptamine are abolished by methiothepin, a potent antagonist of 5-HT receptors. Injection of indirect agonists like pargyline, a monoamine oxidase inhibitor, or fluoxetine, a potent inhibitor of 5-HT reuptake, is followed by an increase of the amplitude of the vestibulo-ocular reflex. These results indicate that 5-HT can modulate the activity of the vestibulo-ocular pathway and muscular tone of extraocular muscles. Location and involvement of various modulating 5-HT sites are discussed.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Electric Stimulation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Injections, Intraventricular</subject><subject>Male</subject><subject>Methiothepin - pharmacology</subject><subject>Methoxydimethyltryptamines - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Reflex, Vestibulo-Ocular - drug effects</subject><subject>Serotonin - administration & dosage</subject><subject>Serotonin - pharmacology</subject><subject>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</subject><subject>Space life sciences</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0031-6768</issn><issn>1432-2013</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1Lw0AQhhdRaq1evAs5iAchOrub7MexFqtCxYuew2Y_MJJm624i9t-7paEOA3N4H16GB6FLDHcYgN8_LAFKQQWIIzTFBSU5AUyP0RSA4pxxJk7RWYxfAEAKQSZoQhnhkrEpmr96M7Sqb3yXeZf1nzb7sbFv6qH1udcpClmwrrW_Wb3Nog2-913TZWl3bFD9OTpxqo32Yrwz9LF8fF8856u3p5fFfJVrQlifSy4LyYmCUipdE6K5w5wLkDVzhqTBWlNbGlI44KZgmmJRGm5M7QhVEugM3ex7N8F_D-nHat1EbdtWddYPseKc41IKmsDbPaiDjzE9X21Cs1ZhW2Godr6qf18Jvhpbh3ptzQEdBaX8esxV1Kp1QXW6iQcsqZWCFPQPX01wlw</recordid><startdate>198708</startdate><enddate>198708</enddate><creator>TERNAUX, J.-P</creator><creator>GAMBARELLI, F</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198708</creationdate><title>Modulation of the vestibulo-ocular reflex by serotonin in the rat</title><author>TERNAUX, J.-P ; GAMBARELLI, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c226t-9794972a059acb22c7f177809b6fd22221cc3e5d24f07d46c3185d7ddbf23a903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Electric Stimulation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Injections, Intraventricular</topic><topic>Male</topic><topic>Methiothepin - pharmacology</topic><topic>Methoxydimethyltryptamines - pharmacology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Reflex, Vestibulo-Ocular - drug effects</topic><topic>Serotonin - administration & dosage</topic><topic>Serotonin - pharmacology</topic><topic>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</topic><topic>Space life sciences</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TERNAUX, J.-P</creatorcontrib><creatorcontrib>GAMBARELLI, F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pflügers Archiv</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TERNAUX, J.-P</au><au>GAMBARELLI, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modulation of the vestibulo-ocular reflex by serotonin in the rat</atitle><jtitle>Pflügers Archiv</jtitle><addtitle>Pflugers Arch</addtitle><date>1987-08</date><risdate>1987</risdate><volume>409</volume><issue>4-5</issue><spage>507</spage><epage>511</epage><pages>507-511</pages><issn>0031-6768</issn><eissn>1432-2013</eissn><coden>PFLABK</coden><abstract>The effects of intraventricular injection of serotonin (5-HT) and its agonists and antagonists on the amplitude of the vestibulo-ocular reflex were studied in chronic implanted rats. 5-HT (10(-5) M) triggers an increase of the amplitude of the reflex which lasts 30 min. Similar results are obtained when N,N-dimethyl-5-methoxytryptamine (10(-3) M) is introduced into the ventricular cannula. The increasing effects observed both with 5-HT and N,N-dimethyl-5-methoxy-tryptamine are abolished by methiothepin, a potent antagonist of 5-HT receptors. Injection of indirect agonists like pargyline, a monoamine oxidase inhibitor, or fluoxetine, a potent inhibitor of 5-HT reuptake, is followed by an increase of the amplitude of the vestibulo-ocular reflex. These results indicate that 5-HT can modulate the activity of the vestibulo-ocular pathway and muscular tone of extraocular muscles. Location and involvement of various modulating 5-HT sites are discussed.</abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>3627966</pmid><doi>10.1007/BF00583808</doi><tpages>5</tpages></addata></record> |
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| language | eng |
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| subjects | Animals Biological and medical sciences Electric Stimulation Fundamental and applied biological sciences. Psychology Injections, Intraventricular Male Methiothepin - pharmacology Methoxydimethyltryptamines - pharmacology Rats Rats, Inbred Strains Reflex, Vestibulo-Ocular - drug effects Serotonin - administration & dosage Serotonin - pharmacology Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Space life sciences Vertebrates: nervous system and sense organs |
| title | Modulation of the vestibulo-ocular reflex by serotonin in the rat |
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