Reduced Incidence of Preterm Delivery with Metronidazole and Erythromycin in Women with Bacterial Vaginosis
Preterm delivery is the primary cause of perinatal mortality in the United States. To date, no effective means of preventing spontaneous preterm delivery has been identified. At least in some cases, however, microbial colonization of the fetal membranes or the amniotic fluid, or alterations in the v...
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| Veröffentlicht in: | The New England journal of medicine 1995-12, Vol.333 (26), p.1732-1736 |
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| container_title | The New England journal of medicine |
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| creator | Hauth, John C Goldenberg, Robert L Andrews, William W DuBard, Mary B Copper, Rachel L |
| description | Preterm delivery is the primary cause of perinatal mortality in the United States. To date, no effective means of preventing spontaneous preterm delivery has been identified. At least in some cases, however, microbial colonization of the fetal membranes or the amniotic fluid, or alterations in the vaginal flora such as are seen in patients with bacterial vaginosis, have been associated with spontaneous labor and preterm delivery.
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We undertook a prospective, double-blind trial to address three questions. First, does antimicrobial therapy reduce the incidence of preterm delivery in women at risk for preterm delivery? Second, does antimicrobial therapy reduce the . . . |
| doi_str_mv | 10.1056/NEJM199512283332603 |
| format | Article |
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We undertook a prospective, double-blind trial to address three questions. First, does antimicrobial therapy reduce the incidence of preterm delivery in women at risk for preterm delivery? Second, does antimicrobial therapy reduce the . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM199512283332603</identifier><identifier>PMID: 7491136</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Adult ; Anti-Bacterial Agents - therapeutic use ; Antitrichomonal Agents - therapeutic use ; Bacterial diseases ; Bacterial diseases of the genital system ; Biological and medical sciences ; Body Weight ; Double-Blind Method ; Erythromycin - therapeutic use ; Female ; Human bacterial diseases ; Humans ; Incidence ; Infections ; Infectious diseases ; Medical sciences ; Metronidazole - therapeutic use ; Obstetric Labor, Premature - epidemiology ; Obstetric Labor, Premature - etiology ; Obstetric Labor, Premature - prevention & control ; Obstetrics ; Pregnancy ; Pregnancy Complications, Infectious - drug therapy ; Premature birth ; Risk Factors ; Treatment Outcome ; Vaginosis, Bacterial - complications ; Vaginosis, Bacterial - drug therapy ; Women</subject><ispartof>The New England journal of medicine, 1995-12, Vol.333 (26), p.1732-1736</ispartof><rights>Copyright © 1995 Massachusetts Medical Society. All rights reserved.</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c588t-5b875a953f92c57b89625cd4a2df7cc08a54e4df05764e08f4c61f367cc90e1d3</citedby><cites>FETCH-LOGICAL-c588t-5b875a953f92c57b89625cd4a2df7cc08a54e4df05764e08f4c61f367cc90e1d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM199512283332603$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJM199512283332603$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2947500$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7491136$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hauth, John C</creatorcontrib><creatorcontrib>Goldenberg, Robert L</creatorcontrib><creatorcontrib>Andrews, William W</creatorcontrib><creatorcontrib>DuBard, Mary B</creatorcontrib><creatorcontrib>Copper, Rachel L</creatorcontrib><title>Reduced Incidence of Preterm Delivery with Metronidazole and Erythromycin in Women with Bacterial Vaginosis</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Preterm delivery is the primary cause of perinatal mortality in the United States. To date, no effective means of preventing spontaneous preterm delivery has been identified. At least in some cases, however, microbial colonization of the fetal membranes or the amniotic fluid, or alterations in the vaginal flora such as are seen in patients with bacterial vaginosis, have been associated with spontaneous labor and preterm delivery.
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We undertook a prospective, double-blind trial to address three questions. First, does antimicrobial therapy reduce the incidence of preterm delivery in women at risk for preterm delivery? Second, does antimicrobial therapy reduce the . . .</description><subject>Adult</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antitrichomonal Agents - therapeutic use</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the genital system</subject><subject>Biological and medical sciences</subject><subject>Body Weight</subject><subject>Double-Blind Method</subject><subject>Erythromycin - therapeutic use</subject><subject>Female</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Metronidazole - therapeutic use</subject><subject>Obstetric Labor, Premature - epidemiology</subject><subject>Obstetric Labor, Premature - etiology</subject><subject>Obstetric Labor, Premature - prevention & control</subject><subject>Obstetrics</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Infectious - drug therapy</subject><subject>Premature birth</subject><subject>Risk Factors</subject><subject>Treatment Outcome</subject><subject>Vaginosis, Bacterial - complications</subject><subject>Vaginosis, Bacterial - drug therapy</subject><subject>Women</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkUuLFDEUhYMoY9v6C0QIIm6G0rxTWerYzoMZFfGxLNLJLSdtVTImVSPtr59IN7MQ0RDI4nz3XHIOQo8peUGJVC_frc4uqDGSMtZyzpki_A5aUMl5IwRRd9GCENY2Qht-Hz0oZUPqocIcoAMtDKVcLdD3j-BnBx6fRhc8RAc49fhDhgnyiN_AEK4hb_HPMF3iC5hyisHbX2kAbKPHq7ydLnMaty5EXO_XNELcwa-tqxbBDviL_RZiKqE8RPd6OxR4tH-X6PPb1aejk-b8_fHp0avzxsm2nRq5brW0RvLeMCf1ujWKSeeFZb7XzpHWSgHC90RqJYC0vXCK9lxVzRCgni_R853vVU4_ZihTN4biYBhshDSXTmtdU6iZ_Q-kmkgma55L9PQPcJPmHOsnOsa4UVpxWSG-g1xOpWTou6scRpu3HSXd78K6vxRWp57sref1CP52Zt9Q1Z_tdVucHfpsa1HlFmNGaElIxQ532DiWLsJm_OfSG4_vqXY</recordid><startdate>19951228</startdate><enddate>19951228</enddate><creator>Hauth, John C</creator><creator>Goldenberg, Robert L</creator><creator>Andrews, William W</creator><creator>DuBard, Mary B</creator><creator>Copper, Rachel L</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>19951228</creationdate><title>Reduced Incidence of Preterm Delivery with Metronidazole and Erythromycin in Women with Bacterial Vaginosis</title><author>Hauth, John C ; Goldenberg, Robert L ; Andrews, William W ; DuBard, Mary B ; Copper, Rachel L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c588t-5b875a953f92c57b89625cd4a2df7cc08a54e4df05764e08f4c61f367cc90e1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adult</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Antitrichomonal Agents - therapeutic use</topic><topic>Bacterial diseases</topic><topic>Bacterial diseases of the genital system</topic><topic>Biological and medical sciences</topic><topic>Body Weight</topic><topic>Double-Blind Method</topic><topic>Erythromycin - therapeutic use</topic><topic>Female</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Metronidazole - therapeutic use</topic><topic>Obstetric Labor, Premature - epidemiology</topic><topic>Obstetric Labor, Premature - etiology</topic><topic>Obstetric Labor, Premature - prevention & control</topic><topic>Obstetrics</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Infectious - drug therapy</topic><topic>Premature birth</topic><topic>Risk Factors</topic><topic>Treatment Outcome</topic><topic>Vaginosis, Bacterial - complications</topic><topic>Vaginosis, Bacterial - 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To date, no effective means of preventing spontaneous preterm delivery has been identified. At least in some cases, however, microbial colonization of the fetal membranes or the amniotic fluid, or alterations in the vaginal flora such as are seen in patients with bacterial vaginosis, have been associated with spontaneous labor and preterm delivery.
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–
10
We undertook a prospective, double-blind trial to address three questions. First, does antimicrobial therapy reduce the incidence of preterm delivery in women at risk for preterm delivery? Second, does antimicrobial therapy reduce the . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><pmid>7491136</pmid><doi>10.1056/NEJM199512283332603</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 1995-12, Vol.333 (26), p.1732-1736 |
| issn | 0028-4793 1533-4406 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | Adult Anti-Bacterial Agents - therapeutic use Antitrichomonal Agents - therapeutic use Bacterial diseases Bacterial diseases of the genital system Biological and medical sciences Body Weight Double-Blind Method Erythromycin - therapeutic use Female Human bacterial diseases Humans Incidence Infections Infectious diseases Medical sciences Metronidazole - therapeutic use Obstetric Labor, Premature - epidemiology Obstetric Labor, Premature - etiology Obstetric Labor, Premature - prevention & control Obstetrics Pregnancy Pregnancy Complications, Infectious - drug therapy Premature birth Risk Factors Treatment Outcome Vaginosis, Bacterial - complications Vaginosis, Bacterial - drug therapy Women |
| title | Reduced Incidence of Preterm Delivery with Metronidazole and Erythromycin in Women with Bacterial Vaginosis |
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