Activation of systemic and mucosal immune response following nasal administration of liposomes
Adjuvant effects of liposomes on systemic and mucosal immune response were investigated following nasal administration to Balb/c mice. Bovine serum albumin (BSA)-specific serum IgG and salivary IgA levels were significantly elevated when BSA-associated liposomes were administered intranasally twice...
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| Veröffentlicht in: | Vaccine 1994, Vol.12 (13), p.1241-1245 |
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| container_issue | 13 |
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| container_title | Vaccine |
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| creator | Aramaki, Yukihiko Fujii, Yoshimine Yachi, Kiyoto Kikuchi, Hiroshi Tsuchiya, Seishi |
| description | Adjuvant effects of liposomes on systemic and mucosal immune response were investigated following nasal administration to Balb/c mice. Bovine serum albumin (BSA)-specific serum IgG and salivary IgA levels were significantly elevated when BSA-associated liposomes were administered intranasally twice at 4-week intervals. Systemic immune response was activated only by negatively charged liposomes, while activation of mucosal immune response was independent of liposomal charge. Antigen localization in liposomes affected immune adjuvant effect; the mucosal immune response could be activated only by liposomes to whose surface BSA was attached, but the systemic immune response was activated by both liposomes to which antigens were attached and in which the encapsulating antigens occurred. The results suggest that the contribution of antigen-presenting cells in activation of systemic and mucosal immunity following intranasal administration is different. |
| doi_str_mv | 10.1016/0264-410X(94)90251-8 |
| format | Article |
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Bovine serum albumin (BSA)-specific serum IgG and salivary IgA levels were significantly elevated when BSA-associated liposomes were administered intranasally twice at 4-week intervals. Systemic immune response was activated only by negatively charged liposomes, while activation of mucosal immune response was independent of liposomal charge. Antigen localization in liposomes affected immune adjuvant effect; the mucosal immune response could be activated only by liposomes to whose surface BSA was attached, but the systemic immune response was activated by both liposomes to which antigens were attached and in which the encapsulating antigens occurred. The results suggest that the contribution of antigen-presenting cells in activation of systemic and mucosal immunity following intranasal administration is different.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/0264-410X(94)90251-8</identifier><identifier>PMID: 7839731</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adjuvants, Immunologic - administration & dosage ; Administration, Intranasal ; Analysis of the immune response. Humoral and cellular immunity ; Animals ; Antigens - administration & dosage ; Biological and medical sciences ; Cattle ; Electrochemistry ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Immunobiology ; Immunoglobulin A - biosynthesis ; Immunoglobulin G - biosynthesis ; Liposome ; Liposomes - administration & dosage ; Liposomes - chemistry ; Liposomes - immunology ; Mice ; Mice, Inbred BALB C ; mucosal immunity ; Mucous Membrane - immunology ; nasal administration ; Nasal Mucosa - immunology ; Organs and cells involved in the immune response ; Saliva - immunology ; Serum Albumin, Bovine - administration & dosage ; Serum Albumin, Bovine - immunology</subject><ispartof>Vaccine, 1994, Vol.12 (13), p.1241-1245</ispartof><rights>1994</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c512t-a8d585b418d22260ae53e2ff1aca9c4795bb0431c9bfa47d4eb67866c8829f13</citedby><cites>FETCH-LOGICAL-c512t-a8d585b418d22260ae53e2ff1aca9c4795bb0431c9bfa47d4eb67866c8829f13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0264410X94902518$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4256399$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7839731$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aramaki, Yukihiko</creatorcontrib><creatorcontrib>Fujii, Yoshimine</creatorcontrib><creatorcontrib>Yachi, Kiyoto</creatorcontrib><creatorcontrib>Kikuchi, Hiroshi</creatorcontrib><creatorcontrib>Tsuchiya, Seishi</creatorcontrib><title>Activation of systemic and mucosal immune response following nasal administration of liposomes</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Adjuvant effects of liposomes on systemic and mucosal immune response were investigated following nasal administration to Balb/c mice. Bovine serum albumin (BSA)-specific serum IgG and salivary IgA levels were significantly elevated when BSA-associated liposomes were administered intranasally twice at 4-week intervals. Systemic immune response was activated only by negatively charged liposomes, while activation of mucosal immune response was independent of liposomal charge. Antigen localization in liposomes affected immune adjuvant effect; the mucosal immune response could be activated only by liposomes to whose surface BSA was attached, but the systemic immune response was activated by both liposomes to which antigens were attached and in which the encapsulating antigens occurred. The results suggest that the contribution of antigen-presenting cells in activation of systemic and mucosal immunity following intranasal administration is different.</description><subject>Adjuvants, Immunologic - administration & dosage</subject><subject>Administration, Intranasal</subject><subject>Analysis of the immune response. Humoral and cellular immunity</subject><subject>Animals</subject><subject>Antigens - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>Cattle</subject><subject>Electrochemistry</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Immunobiology</subject><subject>Immunoglobulin A - biosynthesis</subject><subject>Immunoglobulin G - biosynthesis</subject><subject>Liposome</subject><subject>Liposomes - administration & dosage</subject><subject>Liposomes - chemistry</subject><subject>Liposomes - immunology</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>mucosal immunity</subject><subject>Mucous Membrane - immunology</subject><subject>nasal administration</subject><subject>Nasal Mucosa - immunology</subject><subject>Organs and cells involved in the immune response</subject><subject>Saliva - immunology</subject><subject>Serum Albumin, Bovine - administration & dosage</subject><subject>Serum Albumin, Bovine - immunology</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1rFTEUhoMo9Vr9BwqzkKKLqUkmmSQboRS_oNBNF64MmcyJRCbJNWem0n_fGe_lLnUVwvuc9xweQl4zesko6z9Q3otWMPr9nRHvDeWStfoJ2TGtunb96Kdkd0KekxeIvyilsmPmjJwp3RnVsR35ceXneO_mWHJTQoMPOEOKvnF5bNLiC7qpiSktGZoKuC8ZoQllmsqfmH822W25G1PMEed6qpnivmBJgC_Js-AmhFfH95zcff50d_21vbn98u366qb1kvG5dXqUWg6C6ZFz3lMHsgMeAnPeGS-UkcNARce8GYITahQw9Er3vdeam8C6c3JxqN3X8nsBnG2K6GGaXIayoFVKMc6l-i_I-r4z3JgVFAfQ14JYIdh9jcnVB8uo3fTbza3d3Foj7F_9Vq9jb479y5BgPA0dfa_522Pu0LspVJd9xBMmuFz3b9s_HjBYnd1HqBZ9hOxhjBX8bMcS_33HIwDworU</recordid><startdate>1994</startdate><enddate>1994</enddate><creator>Aramaki, Yukihiko</creator><creator>Fujii, Yoshimine</creator><creator>Yachi, Kiyoto</creator><creator>Kikuchi, Hiroshi</creator><creator>Tsuchiya, Seishi</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>1994</creationdate><title>Activation of systemic and mucosal immune response following nasal administration of liposomes</title><author>Aramaki, Yukihiko ; Fujii, Yoshimine ; Yachi, Kiyoto ; Kikuchi, Hiroshi ; Tsuchiya, Seishi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c512t-a8d585b418d22260ae53e2ff1aca9c4795bb0431c9bfa47d4eb67866c8829f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adjuvants, Immunologic - administration & dosage</topic><topic>Administration, Intranasal</topic><topic>Analysis of the immune response. Humoral and cellular immunity</topic><topic>Animals</topic><topic>Antigens - administration & dosage</topic><topic>Biological and medical sciences</topic><topic>Cattle</topic><topic>Electrochemistry</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Immunobiology</topic><topic>Immunoglobulin A - biosynthesis</topic><topic>Immunoglobulin G - biosynthesis</topic><topic>Liposome</topic><topic>Liposomes - administration & dosage</topic><topic>Liposomes - chemistry</topic><topic>Liposomes - immunology</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>mucosal immunity</topic><topic>Mucous Membrane - immunology</topic><topic>nasal administration</topic><topic>Nasal Mucosa - immunology</topic><topic>Organs and cells involved in the immune response</topic><topic>Saliva - immunology</topic><topic>Serum Albumin, Bovine - administration & dosage</topic><topic>Serum Albumin, Bovine - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aramaki, Yukihiko</creatorcontrib><creatorcontrib>Fujii, Yoshimine</creatorcontrib><creatorcontrib>Yachi, Kiyoto</creatorcontrib><creatorcontrib>Kikuchi, Hiroshi</creatorcontrib><creatorcontrib>Tsuchiya, Seishi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aramaki, Yukihiko</au><au>Fujii, Yoshimine</au><au>Yachi, Kiyoto</au><au>Kikuchi, Hiroshi</au><au>Tsuchiya, Seishi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Activation of systemic and mucosal immune response following nasal administration of liposomes</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>1994</date><risdate>1994</risdate><volume>12</volume><issue>13</issue><spage>1241</spage><epage>1245</epage><pages>1241-1245</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>Adjuvant effects of liposomes on systemic and mucosal immune response were investigated following nasal administration to Balb/c mice. Bovine serum albumin (BSA)-specific serum IgG and salivary IgA levels were significantly elevated when BSA-associated liposomes were administered intranasally twice at 4-week intervals. Systemic immune response was activated only by negatively charged liposomes, while activation of mucosal immune response was independent of liposomal charge. Antigen localization in liposomes affected immune adjuvant effect; the mucosal immune response could be activated only by liposomes to whose surface BSA was attached, but the systemic immune response was activated by both liposomes to which antigens were attached and in which the encapsulating antigens occurred. The results suggest that the contribution of antigen-presenting cells in activation of systemic and mucosal immunity following intranasal administration is different.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>7839731</pmid><doi>10.1016/0264-410X(94)90251-8</doi><tpages>5</tpages></addata></record> |
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| ispartof | Vaccine, 1994, Vol.12 (13), p.1241-1245 |
| issn | 0264-410X 1873-2518 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adjuvants, Immunologic - administration & dosage Administration, Intranasal Analysis of the immune response. Humoral and cellular immunity Animals Antigens - administration & dosage Biological and medical sciences Cattle Electrochemistry Fundamental and applied biological sciences. Psychology Fundamental immunology Immunobiology Immunoglobulin A - biosynthesis Immunoglobulin G - biosynthesis Liposome Liposomes - administration & dosage Liposomes - chemistry Liposomes - immunology Mice Mice, Inbred BALB C mucosal immunity Mucous Membrane - immunology nasal administration Nasal Mucosa - immunology Organs and cells involved in the immune response Saliva - immunology Serum Albumin, Bovine - administration & dosage Serum Albumin, Bovine - immunology |
| title | Activation of systemic and mucosal immune response following nasal administration of liposomes |
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