Chromosomal localization of the major histocompatibility (B) complex (MHC) and its expression in chickens aneuploid for the major histocompatibility complex/ribosomal deoxyribonucleic acid microchromosome
By the cytogenetic method of trisomy mapping, the major histocompatibility complex (MHC) (B) was located on the microchromosome that also contains all of the ribosomal ribonucleic acid (rDNA) genes that are detected as a nucleolar organizer region. Crosses involving aneuploid chickens homozygous or...
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| Veröffentlicht in: | Poultry science 1987-05, Vol.66 (5), p.782-789 |
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| container_title | Poultry science |
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| creator | Bloom, S.E Briles, W.E Briles, R.W Delany, M.E Dietert, R.R |
| description | By the cytogenetic method of trisomy mapping, the major histocompatibility complex (MHC) (B) was located on the microchromosome that also contains all of the ribosomal ribonucleic acid (rDNA) genes that are detected as a nucleolar organizer region. Crosses involving aneuploid chickens homozygous or heterozygous for particular B haplotypes yield an F1 of disomic, trisomic, and tetrasomic offspring suitable for studies of gene dosage effects and gene regulation. Studies to date show that MHC genes are expressed on each chromosome in aneuploid cells unlike the rDNA gene cluster, which is regulated to produce only diploid levels of mature rRNA. Biological effects of extra MHC chromosome dosage range from altered cell surface content of glycoproteins to altered growth potential of chickens. In addition, enhanced MHC-encoded cell surface products may influence the progression of B-cell differentiation and cell population dynamics in the developing bursa of Fabricius. Recent research shows a possible mechanism to account for the formation of unequal products in meiosis within the rDNA and MHC gene clusters. Unequal recombinational events may be promoted in the meiotic process in trisomic chickens. |
| doi_str_mv | 10.3382/ps.0660782 |
| format | Article |
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Crosses involving aneuploid chickens homozygous or heterozygous for particular B haplotypes yield an F1 of disomic, trisomic, and tetrasomic offspring suitable for studies of gene dosage effects and gene regulation. Studies to date show that MHC genes are expressed on each chromosome in aneuploid cells unlike the rDNA gene cluster, which is regulated to produce only diploid levels of mature rRNA. Biological effects of extra MHC chromosome dosage range from altered cell surface content of glycoproteins to altered growth potential of chickens. In addition, enhanced MHC-encoded cell surface products may influence the progression of B-cell differentiation and cell population dynamics in the developing bursa of Fabricius. Recent research shows a possible mechanism to account for the formation of unequal products in meiosis within the rDNA and MHC gene clusters. Unequal recombinational events may be promoted in the meiotic process in trisomic chickens.</description><identifier>ISSN: 0032-5791</identifier><identifier>EISSN: 1525-3171</identifier><identifier>DOI: 10.3382/ps.0660782</identifier><identifier>PMID: 3306642</identifier><language>eng</language><publisher>England</publisher><subject>ADN ; Aneuploidy ; Animals ; ARN ; CHICKENS ; Chickens - genetics ; Chickens - immunology ; CHROMOSOME ; Chromosome Mapping ; CHROMOSOME NUMBER ; CHROMOSOMES ; CROMOSOMAS ; DNA ; DNA, Ribosomal - genetics ; GENE ; GENES ; HISTOCOMPATIBILIDAD ; HISTOCOMPATIBILITE ; HISTOCOMPATIBILITY ; Major Histocompatibility Complex ; NOMBRE CHROMOSOMIQUE ; NUMERO DE CROMOSOMAS ; POLLO ; POULET ; RNA</subject><ispartof>Poultry science, 1987-05, Vol.66 (5), p.782-789</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c339t-b42550c726c6a9a5d309ada2a6548bea5f0ff3b1be6b080b9184a7867f9b5cd3</citedby><cites>FETCH-LOGICAL-c339t-b42550c726c6a9a5d309ada2a6548bea5f0ff3b1be6b080b9184a7867f9b5cd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3306642$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bloom, S.E</creatorcontrib><creatorcontrib>Briles, W.E</creatorcontrib><creatorcontrib>Briles, R.W</creatorcontrib><creatorcontrib>Delany, M.E</creatorcontrib><creatorcontrib>Dietert, R.R</creatorcontrib><title>Chromosomal localization of the major histocompatibility (B) complex (MHC) and its expression in chickens aneuploid for the major histocompatibility complex/ribosomal deoxyribonucleic acid microchromosome</title><title>Poultry science</title><addtitle>Poult Sci</addtitle><description>By the cytogenetic method of trisomy mapping, the major histocompatibility complex (MHC) (B) was located on the microchromosome that also contains all of the ribosomal ribonucleic acid (rDNA) genes that are detected as a nucleolar organizer region. Crosses involving aneuploid chickens homozygous or heterozygous for particular B haplotypes yield an F1 of disomic, trisomic, and tetrasomic offspring suitable for studies of gene dosage effects and gene regulation. Studies to date show that MHC genes are expressed on each chromosome in aneuploid cells unlike the rDNA gene cluster, which is regulated to produce only diploid levels of mature rRNA. Biological effects of extra MHC chromosome dosage range from altered cell surface content of glycoproteins to altered growth potential of chickens. In addition, enhanced MHC-encoded cell surface products may influence the progression of B-cell differentiation and cell population dynamics in the developing bursa of Fabricius. Recent research shows a possible mechanism to account for the formation of unequal products in meiosis within the rDNA and MHC gene clusters. Unequal recombinational events may be promoted in the meiotic process in trisomic chickens.</description><subject>ADN</subject><subject>Aneuploidy</subject><subject>Animals</subject><subject>ARN</subject><subject>CHICKENS</subject><subject>Chickens - genetics</subject><subject>Chickens - immunology</subject><subject>CHROMOSOME</subject><subject>Chromosome Mapping</subject><subject>CHROMOSOME NUMBER</subject><subject>CHROMOSOMES</subject><subject>CROMOSOMAS</subject><subject>DNA</subject><subject>DNA, Ribosomal - genetics</subject><subject>GENE</subject><subject>GENES</subject><subject>HISTOCOMPATIBILIDAD</subject><subject>HISTOCOMPATIBILITE</subject><subject>HISTOCOMPATIBILITY</subject><subject>Major Histocompatibility Complex</subject><subject>NOMBRE CHROMOSOMIQUE</subject><subject>NUMERO DE CROMOSOMAS</subject><subject>POLLO</subject><subject>POULET</subject><subject>RNA</subject><issn>0032-5791</issn><issn>1525-3171</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1v1DAQhi0EKkvhwhkkn1CLlNYf8UeOsAKKVMSBcrZsx2ZdnDi1E2mX38iPwqsNHDmNZt53Hs3oBeAlRleUSnI9lSvEORKSPAIbzAhrKBb4MdggREnDRIefgmel3CNEMOfiDJxRWhdasgG_t7uchlTSoCOMyeoYfuk5pBEmD-edg4O-TxnuQpmTTcNUNRNimA_w4v0lPE6i28OLLzfbS6jHHoa5QLefsivlCAkjtLtgf7qxVNktU0yhh74S_8teudc5mPW03qX94diOi40uWKhtBQ3B5mT_fuCegydex-JerPUc3H38cLe9aW6_fvq8fXfbWEq7uTEtYQxZQbjlutOsp6jTvSaas1Yap5lH3lODjeMGSWQ6LFstJBe-M8z29By8OWGnnB4WV2Y1hGJdjPXDtBQlhMC45V01vj0Z65WlZOfVlMOg80FhpI7JqamoNblqfr1SFzO4_p91jarqr06610npHzkU9f2bFIx2TEhJ_wClyaNM</recordid><startdate>19870501</startdate><enddate>19870501</enddate><creator>Bloom, S.E</creator><creator>Briles, W.E</creator><creator>Briles, R.W</creator><creator>Delany, M.E</creator><creator>Dietert, R.R</creator><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19870501</creationdate><title>Chromosomal localization of the major histocompatibility (B) complex (MHC) and its expression in chickens aneuploid for the major histocompatibility complex/ribosomal deoxyribonucleic acid microchromosome</title><author>Bloom, S.E ; Briles, W.E ; Briles, R.W ; Delany, M.E ; Dietert, R.R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c339t-b42550c726c6a9a5d309ada2a6548bea5f0ff3b1be6b080b9184a7867f9b5cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>ADN</topic><topic>Aneuploidy</topic><topic>Animals</topic><topic>ARN</topic><topic>CHICKENS</topic><topic>Chickens - genetics</topic><topic>Chickens - immunology</topic><topic>CHROMOSOME</topic><topic>Chromosome Mapping</topic><topic>CHROMOSOME NUMBER</topic><topic>CHROMOSOMES</topic><topic>CROMOSOMAS</topic><topic>DNA</topic><topic>DNA, Ribosomal - genetics</topic><topic>GENE</topic><topic>GENES</topic><topic>HISTOCOMPATIBILIDAD</topic><topic>HISTOCOMPATIBILITE</topic><topic>HISTOCOMPATIBILITY</topic><topic>Major Histocompatibility Complex</topic><topic>NOMBRE CHROMOSOMIQUE</topic><topic>NUMERO DE CROMOSOMAS</topic><topic>POLLO</topic><topic>POULET</topic><topic>RNA</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bloom, S.E</creatorcontrib><creatorcontrib>Briles, W.E</creatorcontrib><creatorcontrib>Briles, R.W</creatorcontrib><creatorcontrib>Delany, M.E</creatorcontrib><creatorcontrib>Dietert, R.R</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Poultry science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bloom, S.E</au><au>Briles, W.E</au><au>Briles, R.W</au><au>Delany, M.E</au><au>Dietert, R.R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chromosomal localization of the major histocompatibility (B) complex (MHC) and its expression in chickens aneuploid for the major histocompatibility complex/ribosomal deoxyribonucleic acid microchromosome</atitle><jtitle>Poultry science</jtitle><addtitle>Poult Sci</addtitle><date>1987-05-01</date><risdate>1987</risdate><volume>66</volume><issue>5</issue><spage>782</spage><epage>789</epage><pages>782-789</pages><issn>0032-5791</issn><eissn>1525-3171</eissn><abstract>By the cytogenetic method of trisomy mapping, the major histocompatibility complex (MHC) (B) was located on the microchromosome that also contains all of the ribosomal ribonucleic acid (rDNA) genes that are detected as a nucleolar organizer region. Crosses involving aneuploid chickens homozygous or heterozygous for particular B haplotypes yield an F1 of disomic, trisomic, and tetrasomic offspring suitable for studies of gene dosage effects and gene regulation. Studies to date show that MHC genes are expressed on each chromosome in aneuploid cells unlike the rDNA gene cluster, which is regulated to produce only diploid levels of mature rRNA. Biological effects of extra MHC chromosome dosage range from altered cell surface content of glycoproteins to altered growth potential of chickens. In addition, enhanced MHC-encoded cell surface products may influence the progression of B-cell differentiation and cell population dynamics in the developing bursa of Fabricius. Recent research shows a possible mechanism to account for the formation of unequal products in meiosis within the rDNA and MHC gene clusters. Unequal recombinational events may be promoted in the meiotic process in trisomic chickens.</abstract><cop>England</cop><pmid>3306642</pmid><doi>10.3382/ps.0660782</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Poultry science, 1987-05, Vol.66 (5), p.782-789 |
| issn | 0032-5791 1525-3171 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77711469 |
| source | MEDLINE; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | ADN Aneuploidy Animals ARN CHICKENS Chickens - genetics Chickens - immunology CHROMOSOME Chromosome Mapping CHROMOSOME NUMBER CHROMOSOMES CROMOSOMAS DNA DNA, Ribosomal - genetics GENE GENES HISTOCOMPATIBILIDAD HISTOCOMPATIBILITE HISTOCOMPATIBILITY Major Histocompatibility Complex NOMBRE CHROMOSOMIQUE NUMERO DE CROMOSOMAS POLLO POULET RNA |
| title | Chromosomal localization of the major histocompatibility (B) complex (MHC) and its expression in chickens aneuploid for the major histocompatibility complex/ribosomal deoxyribonucleic acid microchromosome |
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