Response to thymectomy in Chinese patients with myasthenia gravis
Myasthenia gravis was diagnosed in 48 patients between 1985 and 1991 in this Chinese community. Thymectomy was performed on 36 patients and the mean postoperative follow-up period was 49 months. Significant improvement was seen in 72% of the thymectomised patients, with 33% achieving complete remiss...
Gespeichert in:
| Veröffentlicht in: | Journal of the neurological sciences 1994-10, Vol.126 (1), p.84-87 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 87 |
|---|---|
| container_issue | 1 |
| container_start_page | 84 |
| container_title | Journal of the neurological sciences |
| container_volume | 126 |
| creator | Kay, Richard Lam, Simon Wong, K.S. Wang, Angela Ho, Jonathan |
| description | Myasthenia gravis was diagnosed in 48 patients between 1985 and 1991 in this Chinese community. Thymectomy was performed on 36 patients and the mean postoperative follow-up period was 49 months. Significant improvement was seen in 72% of the thymectomised patients, with 33% achieving complete remission. Patients with mild generalised myasthenia at presentation or those found to have thymic hyperplasia had the best prognosis. Patients with more severe symptoms or those with an underlying thymoma also responded favourably. Only patients with ocular myasthenia or those with a normal or atrophic thymus gland had no more than an even chance of gaining significant improvement. Although previous reports suggested a high prevalence of ocular myasthenia and of thymoma among Chinese myasthenic patients, the present study has found no evidence that they respond differently to thymectomy than their Western counterparts. |
| doi_str_mv | 10.1016/0022-510X(94)90098-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_77710529</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0022510X94900981</els_id><sourcerecordid>77710529</sourcerecordid><originalsourceid>FETCH-LOGICAL-c386t-b23fa8791bc20ec5a8f8741788b7a2ada6feb81e88f25284233e0632abb58d173</originalsourceid><addsrcrecordid>eNp9kEtLAzEUhYMotT7-gcIsRHQxmmQeudkIpfiCgiAK7kImc8eJzKMmaaX_3qktXbq6i_Odw-Uj5IzRG0ZZfksp53HG6MeVTK8lpRJitkfGDATEGUCyT8Y75JAcef9FKc0B5IiMBCS5zPiYTF7Rz_vOYxT6KNSrFk3o21Vku2ha2w6HYK6DxS746MeGOmpX2ocaO6ujT6eX1p-Qg0o3Hk-395i8P9y_TZ_i2cvj83Qyi00CeYgLnlQahGSF4RRNpqECkTIBUAjNdanzCgtgCFDxjEPKkwRpnnBdFBmUTCTH5HKzO3f99wJ9UK31BptGd9gvvBJCMJpxOYDpBjSu995hpebOttqtFKNqbU6ttai1FiVT9WdOsaF2vt1fFC2Wu9JW1ZBfbHPtjW4qpztj_Q5LeSp5mg3Y3QbDwcXSolPeDPoMltYNblXZ2___-AXSAooi</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>77710529</pqid></control><display><type>article</type><title>Response to thymectomy in Chinese patients with myasthenia gravis</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Kay, Richard ; Lam, Simon ; Wong, K.S. ; Wang, Angela ; Ho, Jonathan</creator><creatorcontrib>Kay, Richard ; Lam, Simon ; Wong, K.S. ; Wang, Angela ; Ho, Jonathan</creatorcontrib><description>Myasthenia gravis was diagnosed in 48 patients between 1985 and 1991 in this Chinese community. Thymectomy was performed on 36 patients and the mean postoperative follow-up period was 49 months. Significant improvement was seen in 72% of the thymectomised patients, with 33% achieving complete remission. Patients with mild generalised myasthenia at presentation or those found to have thymic hyperplasia had the best prognosis. Patients with more severe symptoms or those with an underlying thymoma also responded favourably. Only patients with ocular myasthenia or those with a normal or atrophic thymus gland had no more than an even chance of gaining significant improvement. Although previous reports suggested a high prevalence of ocular myasthenia and of thymoma among Chinese myasthenic patients, the present study has found no evidence that they respond differently to thymectomy than their Western counterparts.</description><identifier>ISSN: 0022-510X</identifier><identifier>EISSN: 1878-5883</identifier><identifier>DOI: 10.1016/0022-510X(94)90098-1</identifier><identifier>PMID: 7836952</identifier><identifier>CODEN: JNSCAG</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Adolescent ; Adult ; Aged ; Atrophy ; Biological and medical sciences ; Child ; Chinese ; Combined Modality Therapy ; Diseases of striated muscles. Neuromuscular diseases ; Female ; Hong Kong - epidemiology ; Humans ; Hyperplasia ; Male ; Medical sciences ; Middle Aged ; Myasthenia gravis ; Myasthenia Gravis - etiology ; Myasthenia Gravis - mortality ; Myasthenia Gravis - surgery ; Neurology ; Remission Induction ; Retrospective Studies ; Severity of Illness Index ; Thymectomy ; Thymoma - complications ; Thymoma - radiotherapy ; Thymoma - surgery ; Thymus Gland - pathology ; Thymus Neoplasms - complications ; Thymus Neoplasms - radiotherapy ; Thymus Neoplasms - surgery ; Treatment Outcome</subject><ispartof>Journal of the neurological sciences, 1994-10, Vol.126 (1), p.84-87</ispartof><rights>1994</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-b23fa8791bc20ec5a8f8741788b7a2ada6feb81e88f25284233e0632abb58d173</citedby><cites>FETCH-LOGICAL-c386t-b23fa8791bc20ec5a8f8741788b7a2ada6feb81e88f25284233e0632abb58d173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0022-510X(94)90098-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4249245$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7836952$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kay, Richard</creatorcontrib><creatorcontrib>Lam, Simon</creatorcontrib><creatorcontrib>Wong, K.S.</creatorcontrib><creatorcontrib>Wang, Angela</creatorcontrib><creatorcontrib>Ho, Jonathan</creatorcontrib><title>Response to thymectomy in Chinese patients with myasthenia gravis</title><title>Journal of the neurological sciences</title><addtitle>J Neurol Sci</addtitle><description>Myasthenia gravis was diagnosed in 48 patients between 1985 and 1991 in this Chinese community. Thymectomy was performed on 36 patients and the mean postoperative follow-up period was 49 months. Significant improvement was seen in 72% of the thymectomised patients, with 33% achieving complete remission. Patients with mild generalised myasthenia at presentation or those found to have thymic hyperplasia had the best prognosis. Patients with more severe symptoms or those with an underlying thymoma also responded favourably. Only patients with ocular myasthenia or those with a normal or atrophic thymus gland had no more than an even chance of gaining significant improvement. Although previous reports suggested a high prevalence of ocular myasthenia and of thymoma among Chinese myasthenic patients, the present study has found no evidence that they respond differently to thymectomy than their Western counterparts.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Atrophy</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Chinese</subject><subject>Combined Modality Therapy</subject><subject>Diseases of striated muscles. Neuromuscular diseases</subject><subject>Female</subject><subject>Hong Kong - epidemiology</subject><subject>Humans</subject><subject>Hyperplasia</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myasthenia gravis</subject><subject>Myasthenia Gravis - etiology</subject><subject>Myasthenia Gravis - mortality</subject><subject>Myasthenia Gravis - surgery</subject><subject>Neurology</subject><subject>Remission Induction</subject><subject>Retrospective Studies</subject><subject>Severity of Illness Index</subject><subject>Thymectomy</subject><subject>Thymoma - complications</subject><subject>Thymoma - radiotherapy</subject><subject>Thymoma - surgery</subject><subject>Thymus Gland - pathology</subject><subject>Thymus Neoplasms - complications</subject><subject>Thymus Neoplasms - radiotherapy</subject><subject>Thymus Neoplasms - surgery</subject><subject>Treatment Outcome</subject><issn>0022-510X</issn><issn>1878-5883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLAzEUhYMotT7-gcIsRHQxmmQeudkIpfiCgiAK7kImc8eJzKMmaaX_3qktXbq6i_Odw-Uj5IzRG0ZZfksp53HG6MeVTK8lpRJitkfGDATEGUCyT8Y75JAcef9FKc0B5IiMBCS5zPiYTF7Rz_vOYxT6KNSrFk3o21Vku2ha2w6HYK6DxS746MeGOmpX2ocaO6ujT6eX1p-Qg0o3Hk-395i8P9y_TZ_i2cvj83Qyi00CeYgLnlQahGSF4RRNpqECkTIBUAjNdanzCgtgCFDxjEPKkwRpnnBdFBmUTCTH5HKzO3f99wJ9UK31BptGd9gvvBJCMJpxOYDpBjSu995hpebOttqtFKNqbU6ttai1FiVT9WdOsaF2vt1fFC2Wu9JW1ZBfbHPtjW4qpztj_Q5LeSp5mg3Y3QbDwcXSolPeDPoMltYNblXZ2___-AXSAooi</recordid><startdate>19941001</startdate><enddate>19941001</enddate><creator>Kay, Richard</creator><creator>Lam, Simon</creator><creator>Wong, K.S.</creator><creator>Wang, Angela</creator><creator>Ho, Jonathan</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19941001</creationdate><title>Response to thymectomy in Chinese patients with myasthenia gravis</title><author>Kay, Richard ; Lam, Simon ; Wong, K.S. ; Wang, Angela ; Ho, Jonathan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-b23fa8791bc20ec5a8f8741788b7a2ada6feb81e88f25284233e0632abb58d173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Atrophy</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Chinese</topic><topic>Combined Modality Therapy</topic><topic>Diseases of striated muscles. Neuromuscular diseases</topic><topic>Female</topic><topic>Hong Kong - epidemiology</topic><topic>Humans</topic><topic>Hyperplasia</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myasthenia gravis</topic><topic>Myasthenia Gravis - etiology</topic><topic>Myasthenia Gravis - mortality</topic><topic>Myasthenia Gravis - surgery</topic><topic>Neurology</topic><topic>Remission Induction</topic><topic>Retrospective Studies</topic><topic>Severity of Illness Index</topic><topic>Thymectomy</topic><topic>Thymoma - complications</topic><topic>Thymoma - radiotherapy</topic><topic>Thymoma - surgery</topic><topic>Thymus Gland - pathology</topic><topic>Thymus Neoplasms - complications</topic><topic>Thymus Neoplasms - radiotherapy</topic><topic>Thymus Neoplasms - surgery</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kay, Richard</creatorcontrib><creatorcontrib>Lam, Simon</creatorcontrib><creatorcontrib>Wong, K.S.</creatorcontrib><creatorcontrib>Wang, Angela</creatorcontrib><creatorcontrib>Ho, Jonathan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kay, Richard</au><au>Lam, Simon</au><au>Wong, K.S.</au><au>Wang, Angela</au><au>Ho, Jonathan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Response to thymectomy in Chinese patients with myasthenia gravis</atitle><jtitle>Journal of the neurological sciences</jtitle><addtitle>J Neurol Sci</addtitle><date>1994-10-01</date><risdate>1994</risdate><volume>126</volume><issue>1</issue><spage>84</spage><epage>87</epage><pages>84-87</pages><issn>0022-510X</issn><eissn>1878-5883</eissn><coden>JNSCAG</coden><abstract>Myasthenia gravis was diagnosed in 48 patients between 1985 and 1991 in this Chinese community. Thymectomy was performed on 36 patients and the mean postoperative follow-up period was 49 months. Significant improvement was seen in 72% of the thymectomised patients, with 33% achieving complete remission. Patients with mild generalised myasthenia at presentation or those found to have thymic hyperplasia had the best prognosis. Patients with more severe symptoms or those with an underlying thymoma also responded favourably. Only patients with ocular myasthenia or those with a normal or atrophic thymus gland had no more than an even chance of gaining significant improvement. Although previous reports suggested a high prevalence of ocular myasthenia and of thymoma among Chinese myasthenic patients, the present study has found no evidence that they respond differently to thymectomy than their Western counterparts.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>7836952</pmid><doi>10.1016/0022-510X(94)90098-1</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-510X |
| ispartof | Journal of the neurological sciences, 1994-10, Vol.126 (1), p.84-87 |
| issn | 0022-510X 1878-5883 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77710529 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adolescent Adult Aged Atrophy Biological and medical sciences Child Chinese Combined Modality Therapy Diseases of striated muscles. Neuromuscular diseases Female Hong Kong - epidemiology Humans Hyperplasia Male Medical sciences Middle Aged Myasthenia gravis Myasthenia Gravis - etiology Myasthenia Gravis - mortality Myasthenia Gravis - surgery Neurology Remission Induction Retrospective Studies Severity of Illness Index Thymectomy Thymoma - complications Thymoma - radiotherapy Thymoma - surgery Thymus Gland - pathology Thymus Neoplasms - complications Thymus Neoplasms - radiotherapy Thymus Neoplasms - surgery Treatment Outcome |
| title | Response to thymectomy in Chinese patients with myasthenia gravis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T05%3A46%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Response%20to%20thymectomy%20in%20Chinese%20patients%20with%20myasthenia%20gravis&rft.jtitle=Journal%20of%20the%20neurological%20sciences&rft.au=Kay,%20Richard&rft.date=1994-10-01&rft.volume=126&rft.issue=1&rft.spage=84&rft.epage=87&rft.pages=84-87&rft.issn=0022-510X&rft.eissn=1878-5883&rft.coden=JNSCAG&rft_id=info:doi/10.1016/0022-510X(94)90098-1&rft_dat=%3Cproquest_cross%3E77710529%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=77710529&rft_id=info:pmid/7836952&rft_els_id=0022510X94900981&rfr_iscdi=true |