The Effects of Testosterone and Estradiol on Mast Cell Number in the Harderian Gland of the Frog, Rana esculenta
The Harderian gland (HG) of the frog Rana esculenta contains mast cells in the interstitial tissue. The mast cell number (MCN) is influenced by sex hormones. Gonadectomy in both sexes provoked a decrease in MCN in January, while no effect was observed in September. Sex hormone-replacement therapy ga...
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| Veröffentlicht in: | Zoological Science 1995-08, Vol.12 (4), p.457-466 |
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| creator | Di Matteo, Loredana Baccari, Gabriella Chieffi Chieffi, Paolo Minucci, Sergio |
| description | The Harderian gland (HG) of the frog Rana esculenta contains mast cells in the interstitial tissue. The mast cell number (MCN) is influenced by sex hormones. Gonadectomy in both sexes provoked a decrease in MCN in January, while no effect was observed in September. Sex hormone-replacement therapy gave different results; estradiol treatment in castrated males and females always increased MCN, while testosterone did not. Acute estradiol treatment provoked an increase in MCN on days 2 and 4 of treatment and the morphology of the glandular compartment appeared normal. On days 8, 10 and 12 of treatment the MCN drastically decreased. The majority of glandular acini appeared strongly disorganized and the interstitial tissue became hypertrophic in concomitance with an increased vascularization. Our results suggest that estradiol acts by stimulating mast cells and acute estradiol treatment provokes proliferation of interstitial connective tissue together with glandular cells damage. |
| doi_str_mv | 10.2108/zsj.12.457 |
| format | Article |
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The mast cell number (MCN) is influenced by sex hormones. Gonadectomy in both sexes provoked a decrease in MCN in January, while no effect was observed in September. Sex hormone-replacement therapy gave different results; estradiol treatment in castrated males and females always increased MCN, while testosterone did not. Acute estradiol treatment provoked an increase in MCN on days 2 and 4 of treatment and the morphology of the glandular compartment appeared normal. On days 8, 10 and 12 of treatment the MCN drastically decreased. The majority of glandular acini appeared strongly disorganized and the interstitial tissue became hypertrophic in concomitance with an increased vascularization. Our results suggest that estradiol acts by stimulating mast cells and acute estradiol treatment provokes proliferation of interstitial connective tissue together with glandular cells damage.</description><identifier>ISSN: 0289-0003</identifier><identifier>DOI: 10.2108/zsj.12.457</identifier><identifier>PMID: 8528017</identifier><language>eng</language><publisher>Japan: Zoological Society of Japan</publisher><subject>Animals ; Biotechnology ; Estradiol - pharmacology ; Female ; Freshwater ; Harderian Gland - cytology ; Harderian Gland - drug effects ; Harderian Gland - ultrastructure ; Male ; Mast Cells - cytology ; Mast Cells - drug effects ; Microscopy, Electron ; Orchiectomy ; Original Papers ; Ovariectomy ; Rana esculenta ; Testosterone - pharmacology</subject><ispartof>Zoological Science, 1995-08, Vol.12 (4), p.457-466</ispartof><rights>1995 Zoological Society of Japan</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b575t-a3fc7ed3144f8ef8bb184648c186eb81de7797354a7bd5761dfb6941b4bc6003</citedby><cites>FETCH-LOGICAL-b575t-a3fc7ed3144f8ef8bb184648c186eb81de7797354a7bd5761dfb6941b4bc6003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://bioone.org/doi/pdf/10.2108/zsj.12.457$$EPDF$$P50$$Gbioone$$H</linktopdf><link.rule.ids>109,314,780,784,26978,27924,27925,52363,52719</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8528017$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Di Matteo, Loredana</creatorcontrib><creatorcontrib>Baccari, Gabriella Chieffi</creatorcontrib><creatorcontrib>Chieffi, Paolo</creatorcontrib><creatorcontrib>Minucci, Sergio</creatorcontrib><title>The Effects of Testosterone and Estradiol on Mast Cell Number in the Harderian Gland of the Frog, Rana esculenta</title><title>Zoological Science</title><addtitle>Zoolog Sci</addtitle><description>The Harderian gland (HG) of the frog Rana esculenta contains mast cells in the interstitial tissue. 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Our results suggest that estradiol acts by stimulating mast cells and acute estradiol treatment provokes proliferation of interstitial connective tissue together with glandular cells damage.</description><subject>Animals</subject><subject>Biotechnology</subject><subject>Estradiol - pharmacology</subject><subject>Female</subject><subject>Freshwater</subject><subject>Harderian Gland - cytology</subject><subject>Harderian Gland - drug effects</subject><subject>Harderian Gland - ultrastructure</subject><subject>Male</subject><subject>Mast Cells - cytology</subject><subject>Mast Cells - drug effects</subject><subject>Microscopy, Electron</subject><subject>Orchiectomy</subject><subject>Original Papers</subject><subject>Ovariectomy</subject><subject>Rana esculenta</subject><subject>Testosterone - pharmacology</subject><issn>0289-0003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1rGzEQxffQkqZJL70XdCol1K5mrV3Jx2KcD8gHFN-FpB01MmtpK2kx7V8fLV5ybE6Cmac3M-9XVZ-BLmug4se_tF9CvWQNf1ed01qsF5TS1YfqY0p7SkFAA2fVmWhqQYGfV8PuGcnWWjQ5kWDJDlMOKWMMHonyHdmmHFXnQk-CJw8qZbLBvieP40FjJM6TXAxuVewwOuXJTT99KkZT-TqG39_JL-UVwWTGHn1Wl9V7q_qEn-b3otpdb3eb28X9083d5uf9Qje8yQu1soZjtwLGrEArtAbBWiYMiBa1gA45X_NVwxTXXcNb6Kxu1ww006YtB19UX0-2Qwx_xnKUPLhkyubKYxiT5JxDSYe_KYQ1Z6Ik-7awaRkAZUV4dRKaGFKKaOUQ3UHFvxKonBjJwkhCLQujIv4yu476gN2rdAZU-o9z32F87T7nPMjj8SinavC98yj3gzTB55KxVDE706Oc8MsJf5lGGZ0HfjsZahcK4__t9gKxdbdo</recordid><startdate>19950801</startdate><enddate>19950801</enddate><creator>Di Matteo, Loredana</creator><creator>Baccari, Gabriella Chieffi</creator><creator>Chieffi, Paolo</creator><creator>Minucci, Sergio</creator><general>Zoological Society of Japan</general><general>UniBio Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope><scope>7SN</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>19950801</creationdate><title>The Effects of Testosterone and Estradiol on Mast Cell Number in the Harderian Gland of the Frog, Rana esculenta</title><author>Di Matteo, Loredana ; Baccari, Gabriella Chieffi ; Chieffi, Paolo ; Minucci, Sergio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b575t-a3fc7ed3144f8ef8bb184648c186eb81de7797354a7bd5761dfb6941b4bc6003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Biotechnology</topic><topic>Estradiol - pharmacology</topic><topic>Female</topic><topic>Freshwater</topic><topic>Harderian Gland - cytology</topic><topic>Harderian Gland - drug effects</topic><topic>Harderian Gland - ultrastructure</topic><topic>Male</topic><topic>Mast Cells - cytology</topic><topic>Mast Cells - drug effects</topic><topic>Microscopy, Electron</topic><topic>Orchiectomy</topic><topic>Original Papers</topic><topic>Ovariectomy</topic><topic>Rana esculenta</topic><topic>Testosterone - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Di Matteo, Loredana</creatorcontrib><creatorcontrib>Baccari, Gabriella Chieffi</creatorcontrib><creatorcontrib>Chieffi, Paolo</creatorcontrib><creatorcontrib>Minucci, Sergio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Ecology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Zoological Science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Di Matteo, Loredana</au><au>Baccari, Gabriella Chieffi</au><au>Chieffi, Paolo</au><au>Minucci, Sergio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effects of Testosterone and Estradiol on Mast Cell Number in the Harderian Gland of the Frog, Rana esculenta</atitle><jtitle>Zoological Science</jtitle><addtitle>Zoolog Sci</addtitle><date>1995-08-01</date><risdate>1995</risdate><volume>12</volume><issue>4</issue><spage>457</spage><epage>466</epage><pages>457-466</pages><issn>0289-0003</issn><abstract>The Harderian gland (HG) of the frog Rana esculenta contains mast cells in the interstitial tissue. 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| ispartof | Zoological Science, 1995-08, Vol.12 (4), p.457-466 |
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| subjects | Animals Biotechnology Estradiol - pharmacology Female Freshwater Harderian Gland - cytology Harderian Gland - drug effects Harderian Gland - ultrastructure Male Mast Cells - cytology Mast Cells - drug effects Microscopy, Electron Orchiectomy Original Papers Ovariectomy Rana esculenta Testosterone - pharmacology |
| title | The Effects of Testosterone and Estradiol on Mast Cell Number in the Harderian Gland of the Frog, Rana esculenta |
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