Pharmacological characterisation of NK1 receptor antagonist, [D-Trp7]sendide, on behaviour elicited by substance P in the mouse

An analogue of sendide, [D-Trp7]sendide, was newly synthetized and evaluated as a putative NK1 receptor antagonist in a mouse behavioural test. Effects of [D-Trp7]sendide on the scratching, biting and licking response induced by substance P (SP), neurokinin A (NK A) and neurokinin B (NK B) was studi...

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Veröffentlicht in:	Naunyn-Schmiedeberg's archives of pharmacology 1994-10, Vol.350 (4), p.387-392
Hauptverfasser:	Sakurada, T, Yogo, H, Manome, Y, Tan-No, K, Sakurada, S, Yamada, A, Kisara, K, Ohba, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Analgesics - pharmacology Animals Behavior, Animal - drug effects Injections, Spinal Male Mice Molecular Sequence Data Neurokinin-1 Receptor Antagonists Peptide Fragments - antagonists & inhibitors Peptide Fragments - pharmacology Receptors, Neurokinin-1 - metabolism Substance P - antagonists & inhibitors Substance P - pharmacology Tachykinins - antagonists & inhibitors Tachykinins - pharmacology
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