Effects of aging on spinal opioid-induced antinociception

Initial experiments were conducted to determine whether or not the aging process alters the ability of young, mature, or aged male Fischer 344 rats (5- to 6-, 15- to 16-, and 25- to 26-months-old, respectively) to respond to thermal nociceptive stimuli. Using the tail-flick analgesiometric assay, 25...

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Veröffentlicht in:	Neurobiology of aging 1994-03, Vol.15 (2), p.169-174
Hauptverfasser:	Crisp, Terriann, Stafinsky, Janet L., Hoskins, Daryl L., Dayal, Bimleshwar, Chinrock, Karen M., Uram, Marc
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - physiology Analgesics, Opioid - administration & dosage Analgesics, Opioid - pharmacology Animals Antinociception Biological and medical sciences DAMPGO Dose-Response Relationship, Drug DPDPE Enkephalin, Ala-MePhe-Gly Enkephalin, D-Penicillamine (2,5) Enkephalins - administration & dosage Enkephalins - pharmacology Fundamental and applied biological sciences. Psychology Hot Temperature Injections, Spinal Intrathecal opiates Male Nociceptors - drug effects Pain Measurement - drug effects Rats Rats, Inbred F344 Receptors, Opioid, delta - agonists Receptors, Opioid, mu - agonists Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Spinal Cord - physiology Spinal opiate-induced analgesia Tail-flick test Vertebrates: nervous system and sense organs
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