Effects of aging on spinal opioid-induced antinociception
Initial experiments were conducted to determine whether or not the aging process alters the ability of young, mature, or aged male Fischer 344 rats (5- to 6-, 15- to 16-, and 25- to 26-months-old, respectively) to respond to thermal nociceptive stimuli. Using the tail-flick analgesiometric assay, 25...
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| Veröffentlicht in: | Neurobiology of aging 1994-03, Vol.15 (2), p.169-174 |
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| creator | Crisp, Terriann Stafinsky, Janet L. Hoskins, Daryl L. Dayal, Bimleshwar Chinrock, Karen M. Uram, Marc |
| description | Initial experiments were conducted to determine whether or not the aging process alters the ability of young, mature, or aged male Fischer 344 rats (5- to 6-, 15- to 16-, and 25- to 26-months-old, respectively) to respond to thermal nociceptive stimuli. Using the tail-flick analgesiometric assay, 25- to 26-month-old rats responded significantly faster to the heat source than 15- to 16-month-old animals, but no significant differences were noted between the 5- to 6-month-old and aged rats. Another series of investigations compared the effects of aging on the spinal antinociceptive properties of the μ opioid agonist [D-Ala
2,N-methyl-Phe
4,Gly
5-ol] enkephalin (DAMPGO) and the δ agonist [D-Pen
2,D-Pen
5] enkephalin (DPDPE). In these studies, young, mature, and aged rats were injected intrathecally (IT) with different doses of DAMPGO or DPDPE, and opioid-induced antinociception was tested on the tail-flick test. All three age groups responded to IT DAMPGO in a dose-dependent manner but, for the most part, higher spinal doses were required to produce significant elevations in tail-flick latency in the aged cohort of rats. The spinal analgesic effects of DPDPE also declined with advanced age. The aging process apparently alters the pain-inhibitory function of μ and δ opioid receptors in the rat spinal cord. |
| doi_str_mv | 10.1016/0197-4580(94)90108-2 |
| format | Article |
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2,N-methyl-Phe
4,Gly
5-ol] enkephalin (DAMPGO) and the δ agonist [D-Pen
2,D-Pen
5] enkephalin (DPDPE). In these studies, young, mature, and aged rats were injected intrathecally (IT) with different doses of DAMPGO or DPDPE, and opioid-induced antinociception was tested on the tail-flick test. All three age groups responded to IT DAMPGO in a dose-dependent manner but, for the most part, higher spinal doses were required to produce significant elevations in tail-flick latency in the aged cohort of rats. The spinal analgesic effects of DPDPE also declined with advanced age. The aging process apparently alters the pain-inhibitory function of μ and δ opioid receptors in the rat spinal cord.</description><identifier>ISSN: 0197-4580</identifier><identifier>EISSN: 1558-1497</identifier><identifier>DOI: 10.1016/0197-4580(94)90108-2</identifier><identifier>PMID: 7838287</identifier><identifier>CODEN: NEAGDO</identifier><language>eng</language><publisher>London: Elsevier Inc</publisher><subject>Aging - physiology ; Analgesics, Opioid - administration & dosage ; Analgesics, Opioid - pharmacology ; Animals ; Antinociception ; Biological and medical sciences ; DAMPGO ; Dose-Response Relationship, Drug ; DPDPE ; Enkephalin, Ala-MePhe-Gly ; Enkephalin, D-Penicillamine (2,5) ; Enkephalins - administration & dosage ; Enkephalins - pharmacology ; Fundamental and applied biological sciences. Psychology ; Hot Temperature ; Injections, Spinal ; Intrathecal opiates ; Male ; Nociceptors - drug effects ; Pain Measurement - drug effects ; Rats ; Rats, Inbred F344 ; Receptors, Opioid, delta - agonists ; Receptors, Opioid, mu - agonists ; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors ; Spinal Cord - physiology ; Spinal opiate-induced analgesia ; Tail-flick test ; Vertebrates: nervous system and sense organs</subject><ispartof>Neurobiology of aging, 1994-03, Vol.15 (2), p.169-174</ispartof><rights>1994</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-230d7dad94116867d50971ecfc73f539940435788e12eeedd39cf95e7330130d3</citedby><cites>FETCH-LOGICAL-c452t-230d7dad94116867d50971ecfc73f539940435788e12eeedd39cf95e7330130d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0197458094901082$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3537,23909,23910,25118,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4237941$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7838287$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Crisp, Terriann</creatorcontrib><creatorcontrib>Stafinsky, Janet L.</creatorcontrib><creatorcontrib>Hoskins, Daryl L.</creatorcontrib><creatorcontrib>Dayal, Bimleshwar</creatorcontrib><creatorcontrib>Chinrock, Karen M.</creatorcontrib><creatorcontrib>Uram, Marc</creatorcontrib><title>Effects of aging on spinal opioid-induced antinociception</title><title>Neurobiology of aging</title><addtitle>Neurobiol Aging</addtitle><description>Initial experiments were conducted to determine whether or not the aging process alters the ability of young, mature, or aged male Fischer 344 rats (5- to 6-, 15- to 16-, and 25- to 26-months-old, respectively) to respond to thermal nociceptive stimuli. Using the tail-flick analgesiometric assay, 25- to 26-month-old rats responded significantly faster to the heat source than 15- to 16-month-old animals, but no significant differences were noted between the 5- to 6-month-old and aged rats. Another series of investigations compared the effects of aging on the spinal antinociceptive properties of the μ opioid agonist [D-Ala
2,N-methyl-Phe
4,Gly
5-ol] enkephalin (DAMPGO) and the δ agonist [D-Pen
2,D-Pen
5] enkephalin (DPDPE). In these studies, young, mature, and aged rats were injected intrathecally (IT) with different doses of DAMPGO or DPDPE, and opioid-induced antinociception was tested on the tail-flick test. All three age groups responded to IT DAMPGO in a dose-dependent manner but, for the most part, higher spinal doses were required to produce significant elevations in tail-flick latency in the aged cohort of rats. The spinal analgesic effects of DPDPE also declined with advanced age. The aging process apparently alters the pain-inhibitory function of μ and δ opioid receptors in the rat spinal cord.</description><subject>Aging - physiology</subject><subject>Analgesics, Opioid - administration & dosage</subject><subject>Analgesics, Opioid - pharmacology</subject><subject>Animals</subject><subject>Antinociception</subject><subject>Biological and medical sciences</subject><subject>DAMPGO</subject><subject>Dose-Response Relationship, Drug</subject><subject>DPDPE</subject><subject>Enkephalin, Ala-MePhe-Gly</subject><subject>Enkephalin, D-Penicillamine (2,5)</subject><subject>Enkephalins - administration & dosage</subject><subject>Enkephalins - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hot Temperature</subject><subject>Injections, Spinal</subject><subject>Intrathecal opiates</subject><subject>Male</subject><subject>Nociceptors - drug effects</subject><subject>Pain Measurement - drug effects</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Receptors, Opioid, delta - agonists</subject><subject>Receptors, Opioid, mu - agonists</subject><subject>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</subject><subject>Spinal Cord - physiology</subject><subject>Spinal opiate-induced analgesia</subject><subject>Tail-flick test</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0197-4580</issn><issn>1558-1497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMoWqv_QGEPInpYTTbZTnIRROoHCF70HGIykcg2WTdbwX9vakuPnuYwz_sy8xBywugVo2x2TZmCWrSSXihxqSijsm52yIS1rayZULBLJlvkgBzm_EkpBQGzfbIPkstGwoSoufdox1wlX5mPED-qFKvch2i6KvUhBVeH6JYWXWXiGGKywWI_hhSPyJ43XcbjzZySt_v5691j_fzy8HR3-1xb0TZj3XDqwBmnBGMzOQPXUgUMrbfAfcuVElTwFqRE1iCic1xZr1oEzikrWT4l5-vefkhfS8yjXoRssetMxLTMGgAo0MJOiViDdkg5D-h1P4SFGX40o3plTK906JUOrYT-M6abEjvd9C_fF-i2oY2isj_b7E22pvODiTbkLSYaDuW3gt2sMSwuvgMOOtuAsYgLQxGsXQr_3_ELz-eFlA</recordid><startdate>19940301</startdate><enddate>19940301</enddate><creator>Crisp, Terriann</creator><creator>Stafinsky, Janet L.</creator><creator>Hoskins, Daryl L.</creator><creator>Dayal, Bimleshwar</creator><creator>Chinrock, Karen M.</creator><creator>Uram, Marc</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19940301</creationdate><title>Effects of aging on spinal opioid-induced antinociception</title><author>Crisp, Terriann ; Stafinsky, Janet L. ; Hoskins, Daryl L. ; Dayal, Bimleshwar ; Chinrock, Karen M. ; Uram, Marc</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-230d7dad94116867d50971ecfc73f539940435788e12eeedd39cf95e7330130d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Aging - physiology</topic><topic>Analgesics, Opioid - administration & dosage</topic><topic>Analgesics, Opioid - pharmacology</topic><topic>Animals</topic><topic>Antinociception</topic><topic>Biological and medical sciences</topic><topic>DAMPGO</topic><topic>Dose-Response Relationship, Drug</topic><topic>DPDPE</topic><topic>Enkephalin, Ala-MePhe-Gly</topic><topic>Enkephalin, D-Penicillamine (2,5)</topic><topic>Enkephalins - administration & dosage</topic><topic>Enkephalins - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hot Temperature</topic><topic>Injections, Spinal</topic><topic>Intrathecal opiates</topic><topic>Male</topic><topic>Nociceptors - drug effects</topic><topic>Pain Measurement - drug effects</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Receptors, Opioid, delta - agonists</topic><topic>Receptors, Opioid, mu - agonists</topic><topic>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</topic><topic>Spinal Cord - physiology</topic><topic>Spinal opiate-induced analgesia</topic><topic>Tail-flick test</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Crisp, Terriann</creatorcontrib><creatorcontrib>Stafinsky, Janet L.</creatorcontrib><creatorcontrib>Hoskins, Daryl L.</creatorcontrib><creatorcontrib>Dayal, Bimleshwar</creatorcontrib><creatorcontrib>Chinrock, Karen M.</creatorcontrib><creatorcontrib>Uram, Marc</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neurobiology of aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Crisp, Terriann</au><au>Stafinsky, Janet L.</au><au>Hoskins, Daryl L.</au><au>Dayal, Bimleshwar</au><au>Chinrock, Karen M.</au><au>Uram, Marc</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of aging on spinal opioid-induced antinociception</atitle><jtitle>Neurobiology of aging</jtitle><addtitle>Neurobiol Aging</addtitle><date>1994-03-01</date><risdate>1994</risdate><volume>15</volume><issue>2</issue><spage>169</spage><epage>174</epage><pages>169-174</pages><issn>0197-4580</issn><eissn>1558-1497</eissn><coden>NEAGDO</coden><abstract>Initial experiments were conducted to determine whether or not the aging process alters the ability of young, mature, or aged male Fischer 344 rats (5- to 6-, 15- to 16-, and 25- to 26-months-old, respectively) to respond to thermal nociceptive stimuli. Using the tail-flick analgesiometric assay, 25- to 26-month-old rats responded significantly faster to the heat source than 15- to 16-month-old animals, but no significant differences were noted between the 5- to 6-month-old and aged rats. Another series of investigations compared the effects of aging on the spinal antinociceptive properties of the μ opioid agonist [D-Ala
2,N-methyl-Phe
4,Gly
5-ol] enkephalin (DAMPGO) and the δ agonist [D-Pen
2,D-Pen
5] enkephalin (DPDPE). In these studies, young, mature, and aged rats were injected intrathecally (IT) with different doses of DAMPGO or DPDPE, and opioid-induced antinociception was tested on the tail-flick test. All three age groups responded to IT DAMPGO in a dose-dependent manner but, for the most part, higher spinal doses were required to produce significant elevations in tail-flick latency in the aged cohort of rats. The spinal analgesic effects of DPDPE also declined with advanced age. The aging process apparently alters the pain-inhibitory function of μ and δ opioid receptors in the rat spinal cord.</abstract><cop>London</cop><pub>Elsevier Inc</pub><pmid>7838287</pmid><doi>10.1016/0197-4580(94)90108-2</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0197-4580 |
| ispartof | Neurobiology of aging, 1994-03, Vol.15 (2), p.169-174 |
| issn | 0197-4580 1558-1497 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Aging - physiology Analgesics, Opioid - administration & dosage Analgesics, Opioid - pharmacology Animals Antinociception Biological and medical sciences DAMPGO Dose-Response Relationship, Drug DPDPE Enkephalin, Ala-MePhe-Gly Enkephalin, D-Penicillamine (2,5) Enkephalins - administration & dosage Enkephalins - pharmacology Fundamental and applied biological sciences. Psychology Hot Temperature Injections, Spinal Intrathecal opiates Male Nociceptors - drug effects Pain Measurement - drug effects Rats Rats, Inbred F344 Receptors, Opioid, delta - agonists Receptors, Opioid, mu - agonists Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Spinal Cord - physiology Spinal opiate-induced analgesia Tail-flick test Vertebrates: nervous system and sense organs |
| title | Effects of aging on spinal opioid-induced antinociception |
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