Disagreement between the Roche Cobas® Core and Hybritech TANDEM®-E PSA Assays When Measuring Free, Complexed and Total Serum Prostate Specific Antigen
A comparison of the Roche Cobas® Core and Hybritech TANDEM®-E PSA (prostate specific antigen) assays revealed a large difference in the reactivity of each assay to the separated free and complexed forms of serum PSA in patients with prostatic carcinoma. The Roche assay was relatively much more respo...
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| Veröffentlicht in: | Annals of clinical biochemistry 1994-09, Vol.31 (5), p.501-505 |
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| container_title | Annals of clinical biochemistry |
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| creator | Tillyer, Colin R Konings, Monique Gobin, Philip T Iqbal, Jahangir |
| description | A comparison of the Roche Cobas® Core and Hybritech TANDEM®-E PSA (prostate specific antigen) assays revealed a large difference in the reactivity of each assay to the separated free and complexed forms of serum PSA in patients with prostatic carcinoma. The Roche assay was relatively much more responsive to the free form, but the Hybritech assay was relatively more responsive to the complexed form and total serum PSA. It is possible that the adoption of a universal standard for PSA will not completely resolve the disagreement between PSA assay on individual patient samples, and the use of separate assays for the free and complexed forms may be necessary for the further clinical development of PSA as a tumour marker. |
| doi_str_mv | 10.1177/000456329403100514 |
| format | Article |
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The Roche assay was relatively much more responsive to the free form, but the Hybritech assay was relatively more responsive to the complexed form and total serum PSA. 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Miscellaneous investigative techniques</subject><subject>Prostate-Specific Antigen - blood</subject><subject>Prostatic Neoplasms - blood</subject><subject>Prostatic Neoplasms - diagnosis</subject><subject>Reference Standards</subject><subject>Reproducibility of Results</subject><subject>Urinary system</subject><issn>0004-5632</issn><issn>1758-1001</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9u1DAQxi0EKtvCCyAh-YA4NdSO7Tg5RtstRWqhYhdxjBxnsusqfxbbEeyb8BR9iD4Zs-yqFyQu_jSa3_eNNUPIG84-cK71BWNMqkykhWSCM6a4fEZmXKs8wYo_J7M9kOyJl-Q0hHssU83YCTnRSjAp2Yz8vnTBrD1AD0OkNcSfAAONG6BfR4vvfKxNeHxA9UDN0NDrXe1dBLuhq_Lz5eL28SFZ0LtlScsQzC7Q7xv034IJk3fDml5h9Dm6-20Hv6D5G7Eao-noEvzU0zs_hmgi0OUWrGudpeUQ3RqGV-RFa7oAr496Rr5dLVbz6-Tmy8dP8_ImsWlRxETUKHkmpQKeN2lWN1phkbW8FY2SORiBq2pNYS1kumCZNI3WWc6FVYo3WpyR94fcrR9_TBBi1btgoevMAOMUKq01mgqGYHoALX45eGirrXe98buKs2p_jurfc6Dp7TF9qntonizH_WP_3bFvgjVd681gXXjChEwV1xliFwcMbwXV_Tj5AXfyv8F_ABufnyM</recordid><startdate>19940901</startdate><enddate>19940901</enddate><creator>Tillyer, Colin R</creator><creator>Konings, Monique</creator><creator>Gobin, Philip T</creator><creator>Iqbal, Jahangir</creator><general>SAGE Publications</general><general>Royal Society of Medicine Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19940901</creationdate><title>Disagreement between the Roche Cobas® Core and Hybritech TANDEM®-E PSA Assays When Measuring Free, Complexed and Total Serum Prostate Specific Antigen</title><author>Tillyer, Colin R ; Konings, Monique ; Gobin, Philip T ; Iqbal, Jahangir</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c299t-3b29986445e18d26bd754456f1f3d548ea3117fa9cce679064ad776813c551d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>alpha 1-Antichymotrypsin - chemistry</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - blood</topic><topic>Buffers</topic><topic>Chemical Fractionation</topic><topic>Chromatography, Gel</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Linear Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Prostate-Specific Antigen - blood</topic><topic>Prostatic Neoplasms - blood</topic><topic>Prostatic Neoplasms - diagnosis</topic><topic>Reference Standards</topic><topic>Reproducibility of Results</topic><topic>Urinary system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tillyer, Colin R</creatorcontrib><creatorcontrib>Konings, Monique</creatorcontrib><creatorcontrib>Gobin, Philip T</creatorcontrib><creatorcontrib>Iqbal, Jahangir</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of clinical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tillyer, Colin R</au><au>Konings, Monique</au><au>Gobin, Philip T</au><au>Iqbal, Jahangir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Disagreement between the Roche Cobas® Core and Hybritech TANDEM®-E PSA Assays When Measuring Free, Complexed and Total Serum Prostate Specific Antigen</atitle><jtitle>Annals of clinical biochemistry</jtitle><addtitle>Ann Clin Biochem</addtitle><date>1994-09-01</date><risdate>1994</risdate><volume>31</volume><issue>5</issue><spage>501</spage><epage>505</epage><pages>501-505</pages><issn>0004-5632</issn><eissn>1758-1001</eissn><coden>ACBOBU</coden><abstract>A comparison of the Roche Cobas® Core and Hybritech TANDEM®-E PSA (prostate specific antigen) assays revealed a large difference in the reactivity of each assay to the separated free and complexed forms of serum PSA in patients with prostatic carcinoma. The Roche assay was relatively much more responsive to the free form, but the Hybritech assay was relatively more responsive to the complexed form and total serum PSA. It is possible that the adoption of a universal standard for PSA will not completely resolve the disagreement between PSA assay on individual patient samples, and the use of separate assays for the free and complexed forms may be necessary for the further clinical development of PSA as a tumour marker.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>7530440</pmid><doi>10.1177/000456329403100514</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Annals of clinical biochemistry, 1994-09, Vol.31 (5), p.501-505 |
| issn | 0004-5632 1758-1001 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | alpha 1-Antichymotrypsin - chemistry Biological and medical sciences Biomarkers, Tumor - blood Buffers Chemical Fractionation Chromatography, Gel Humans Immunoenzyme Techniques Investigative techniques, diagnostic techniques (general aspects) Linear Models Male Medical sciences Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Prostate-Specific Antigen - blood Prostatic Neoplasms - blood Prostatic Neoplasms - diagnosis Reference Standards Reproducibility of Results Urinary system |
| title | Disagreement between the Roche Cobas® Core and Hybritech TANDEM®-E PSA Assays When Measuring Free, Complexed and Total Serum Prostate Specific Antigen |
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