Hypothalamic neuropeptides could mediate the anorectic effects of fenfluramine
OXYTOCIN, vasopressin in and corticotrophin releasing factor have anorectic properties when injected centrally. We studied the kinetics of these neuropeptides by injecting fenfluramine, a drug which reduces food intake, in Long Evans rats. The drug was injected daily through a double chronic cannula...
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| Veröffentlicht in: | Neuroreport 1994-10, Vol.5 (15), p.1925-1928 |
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| container_end_page | 1928 |
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| container_issue | 15 |
| container_start_page | 1925 |
| container_title | Neuroreport |
| container_volume | 5 |
| creator | Max, Jean P Thystere, Parfait Chapleur-Chateau, Michele Burlet, Arlette Nicolas, Jean P Burlet, Claude |
| description | OXYTOCIN, vasopressin in and corticotrophin releasing factor have anorectic properties when injected centrally. We studied the kinetics of these neuropeptides by injecting fenfluramine, a drug which reduces food intake, in Long Evans rats. The drug was injected daily through a double chronic cannula implanted above the paraventricular nucleus of the hypothalamus; the rats had free access to pure macronutrients. The rats lost weight during the treatment. Their total caloric intake decreased mostly because the carbohydrate intake decreased, while the protein intake increased slightly. The synthesis and release of brain oxytocin and vasopressin were increased and the release of corticotrophin releasing factor was stimulated. The neuropeptides could be involved in fenfluramine-triggered mechanisms. |
| doi_str_mv | 10.1097/00001756-199410000-00021 |
| format | Article |
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We studied the kinetics of these neuropeptides by injecting fenfluramine, a drug which reduces food intake, in Long Evans rats. The drug was injected daily through a double chronic cannula implanted above the paraventricular nucleus of the hypothalamus; the rats had free access to pure macronutrients. The rats lost weight during the treatment. Their total caloric intake decreased mostly because the carbohydrate intake decreased, while the protein intake increased slightly. The synthesis and release of brain oxytocin and vasopressin were increased and the release of corticotrophin releasing factor was stimulated. The neuropeptides could be involved in fenfluramine-triggered mechanisms.</description><identifier>ISSN: 0959-4965</identifier><identifier>EISSN: 1473-558X</identifier><identifier>DOI: 10.1097/00001756-199410000-00021</identifier><identifier>PMID: 7841378</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott-Raven Publishers</publisher><subject>Animals ; Appetite Depressants - pharmacology ; Biological and medical sciences ; Blood Glucose - metabolism ; Corticotropin-Releasing Hormone - pharmacology ; Eating - drug effects ; Feeding. Feeding behavior ; Fenfluramine - administration & dosage ; Fenfluramine - pharmacology ; Fundamental and applied biological sciences. Psychology ; Hypothalamus - drug effects ; Hypothalamus - metabolism ; Hypothalamus - physiology ; Injections ; Kinetics ; Male ; Neuropeptides - physiology ; Oxytocin - pharmacology ; Paraventricular Hypothalamic Nucleus ; Rats ; Vasopressins - pharmacology ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Weight Loss - drug effects</subject><ispartof>Neuroreport, 1994-10, Vol.5 (15), p.1925-1928</ispartof><rights>Lippincott-Raven Publishers.</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4151-698e85987f11edf30057bc691779b9eac8faf3dfc4acfb03cf2dfea3f02ec5853</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4263567$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7841378$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Max, Jean P</creatorcontrib><creatorcontrib>Thystere, Parfait</creatorcontrib><creatorcontrib>Chapleur-Chateau, Michele</creatorcontrib><creatorcontrib>Burlet, Arlette</creatorcontrib><creatorcontrib>Nicolas, Jean P</creatorcontrib><creatorcontrib>Burlet, Claude</creatorcontrib><title>Hypothalamic neuropeptides could mediate the anorectic effects of fenfluramine</title><title>Neuroreport</title><addtitle>Neuroreport</addtitle><description>OXYTOCIN, vasopressin in and corticotrophin releasing factor have anorectic properties when injected centrally. We studied the kinetics of these neuropeptides by injecting fenfluramine, a drug which reduces food intake, in Long Evans rats. The drug was injected daily through a double chronic cannula implanted above the paraventricular nucleus of the hypothalamus; the rats had free access to pure macronutrients. The rats lost weight during the treatment. Their total caloric intake decreased mostly because the carbohydrate intake decreased, while the protein intake increased slightly. The synthesis and release of brain oxytocin and vasopressin were increased and the release of corticotrophin releasing factor was stimulated. The neuropeptides could be involved in fenfluramine-triggered mechanisms.</description><subject>Animals</subject><subject>Appetite Depressants - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Corticotropin-Releasing Hormone - pharmacology</subject><subject>Eating - drug effects</subject><subject>Feeding. Feeding behavior</subject><subject>Fenfluramine - administration & dosage</subject><subject>Fenfluramine - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hypothalamus - drug effects</subject><subject>Hypothalamus - metabolism</subject><subject>Hypothalamus - physiology</subject><subject>Injections</subject><subject>Kinetics</subject><subject>Male</subject><subject>Neuropeptides - physiology</subject><subject>Oxytocin - pharmacology</subject><subject>Paraventricular Hypothalamic Nucleus</subject><subject>Rats</subject><subject>Vasopressins - pharmacology</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Weight Loss - drug effects</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkd9LHDEQgENpsaf2Tyjsg_RtNbP5_SjSVkH0pQXfQi474bbNbdZkF_G_b_TOe5MGQmaYb2bgCyEN0HOgRl3QekAJ2YIxHF6ytt4OPpAVcMVaIfTDR7KiRpiWGyk-k-NS_lTEUNBH5EhpDkzpFbm7fp7SvHHRbQffjLjkNOE0Dz2Wxqcl9s0W-8HN2MwbbNyYMvq5khhCDUqTQhNwDHHJdcCIp-RTcLHgl_17Qn7_-P7r6rq9vf95c3V523oOAlppNGphtAoA2AdGqVBrLw0oZdYGndfBBdYHz50Pa8p86PqAjgXaoRdasBPybTd3yulxwTLb7VA8xuhGTEuxSikqmYH_giAlhw50BfUO9DmVkjHYKQ9bl58tUPvi3L45twfn9tV5bf2637Gsq61D415yrZ_t6654F0N2ox_KAeOdZEKqivEd9pTijLn8jcsTZrtBF-eNfe_H2T94Tpod</recordid><startdate>19941003</startdate><enddate>19941003</enddate><creator>Max, Jean P</creator><creator>Thystere, Parfait</creator><creator>Chapleur-Chateau, Michele</creator><creator>Burlet, Arlette</creator><creator>Nicolas, Jean P</creator><creator>Burlet, Claude</creator><general>Lippincott-Raven Publishers</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19941003</creationdate><title>Hypothalamic neuropeptides could mediate the anorectic effects of fenfluramine</title><author>Max, Jean P ; Thystere, Parfait ; Chapleur-Chateau, Michele ; Burlet, Arlette ; Nicolas, Jean P ; Burlet, Claude</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4151-698e85987f11edf30057bc691779b9eac8faf3dfc4acfb03cf2dfea3f02ec5853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Appetite Depressants - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>Corticotropin-Releasing Hormone - pharmacology</topic><topic>Eating - drug effects</topic><topic>Feeding. Feeding behavior</topic><topic>Fenfluramine - administration & dosage</topic><topic>Fenfluramine - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hypothalamus - drug effects</topic><topic>Hypothalamus - metabolism</topic><topic>Hypothalamus - physiology</topic><topic>Injections</topic><topic>Kinetics</topic><topic>Male</topic><topic>Neuropeptides - physiology</topic><topic>Oxytocin - pharmacology</topic><topic>Paraventricular Hypothalamic Nucleus</topic><topic>Rats</topic><topic>Vasopressins - pharmacology</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Weight Loss - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Max, Jean P</creatorcontrib><creatorcontrib>Thystere, Parfait</creatorcontrib><creatorcontrib>Chapleur-Chateau, Michele</creatorcontrib><creatorcontrib>Burlet, Arlette</creatorcontrib><creatorcontrib>Nicolas, Jean P</creatorcontrib><creatorcontrib>Burlet, Claude</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Max, Jean P</au><au>Thystere, Parfait</au><au>Chapleur-Chateau, Michele</au><au>Burlet, Arlette</au><au>Nicolas, Jean P</au><au>Burlet, Claude</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypothalamic neuropeptides could mediate the anorectic effects of fenfluramine</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>1994-10-03</date><risdate>1994</risdate><volume>5</volume><issue>15</issue><spage>1925</spage><epage>1928</epage><pages>1925-1928</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>OXYTOCIN, vasopressin in and corticotrophin releasing factor have anorectic properties when injected centrally. We studied the kinetics of these neuropeptides by injecting fenfluramine, a drug which reduces food intake, in Long Evans rats. The drug was injected daily through a double chronic cannula implanted above the paraventricular nucleus of the hypothalamus; the rats had free access to pure macronutrients. The rats lost weight during the treatment. Their total caloric intake decreased mostly because the carbohydrate intake decreased, while the protein intake increased slightly. The synthesis and release of brain oxytocin and vasopressin were increased and the release of corticotrophin releasing factor was stimulated. The neuropeptides could be involved in fenfluramine-triggered mechanisms.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>7841378</pmid><doi>10.1097/00001756-199410000-00021</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Animals Appetite Depressants - pharmacology Biological and medical sciences Blood Glucose - metabolism Corticotropin-Releasing Hormone - pharmacology Eating - drug effects Feeding. Feeding behavior Fenfluramine - administration & dosage Fenfluramine - pharmacology Fundamental and applied biological sciences. Psychology Hypothalamus - drug effects Hypothalamus - metabolism Hypothalamus - physiology Injections Kinetics Male Neuropeptides - physiology Oxytocin - pharmacology Paraventricular Hypothalamic Nucleus Rats Vasopressins - pharmacology Vertebrates: anatomy and physiology, studies on body, several organs or systems Weight Loss - drug effects |
| title | Hypothalamic neuropeptides could mediate the anorectic effects of fenfluramine |
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