Peroxisome proliferation and associated effects caused by perfluorooctanoic acid in vitamin A-deficient mice
Vitamin A-deficient male mice were treated for 10 days with 0.02% perfluorooctanoic acid (PFOA) in their diet. The effects of this highly potent peroxisome proliferator on peroxisomal palmitoyl-CoA oxidation and lauroyl-CoA oxidase activities were reduced by 3.1–7.5 times in comparision to the value...
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| Veröffentlicht in: | Chemico-biological interactions 1995-10, Vol.98 (1), p.45-50 |
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| creator | Sohlenius, Anna-Karin Andersson, Karin Olsson, Jarl DePierre, Joseph W. |
| description | Vitamin A-deficient male mice were treated for 10 days with 0.02% perfluorooctanoic acid (PFOA) in their diet. The effects of this highly potent peroxisome proliferator on peroxisomal palmitoyl-CoA oxidation and lauroyl-CoA oxidase activities were reduced by 3.1–7.5 times in comparision to the values obtained with mice receiving a vitamin A-adequate diet. The activity of peroxisomal catalase was virtually unaffected by vitamin A deficiency and treatment with PFOA had no significant effect on this activity in vitamin A-adequate or vitamin A-deficient mice. However, vitamin A deficiency itself caused a more than 800% increase in cytosolic catalase activity. Thus, the precentage increase caused by PFOA on cytosolic catalase activity was reduced 12.6 times in vitamin A-deficent mice compared to the increase in vitamin A-adequate mice, although the total absolute activities were similar. These findings suggest that the peroxisome proliferation caused by this peroxisome proliferator is highly depedent on the vitamin A status of the mouse. |
| doi_str_mv | 10.1016/0009-2797(95)03630-5 |
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The effects of this highly potent peroxisome proliferator on peroxisomal palmitoyl-CoA oxidation and lauroyl-CoA oxidase activities were reduced by 3.1–7.5 times in comparision to the values obtained with mice receiving a vitamin A-adequate diet. The activity of peroxisomal catalase was virtually unaffected by vitamin A deficiency and treatment with PFOA had no significant effect on this activity in vitamin A-adequate or vitamin A-deficient mice. However, vitamin A deficiency itself caused a more than 800% increase in cytosolic catalase activity. Thus, the precentage increase caused by PFOA on cytosolic catalase activity was reduced 12.6 times in vitamin A-deficent mice compared to the increase in vitamin A-adequate mice, although the total absolute activities were similar. These findings suggest that the peroxisome proliferation caused by this peroxisome proliferator is highly depedent on the vitamin A status of the mouse.</description><identifier>ISSN: 0009-2797</identifier><identifier>EISSN: 1872-7786</identifier><identifier>DOI: 10.1016/0009-2797(95)03630-5</identifier><identifier>PMID: 7586050</identifier><identifier>CODEN: CBINA8</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Acyl-CoA Oxidase ; Animals ; Biological and medical sciences ; Caprylates - pharmacology ; Carcinogenesis, carcinogens and anticarcinogens ; Catalase - metabolism ; Chemical agents ; Cytosol - enzymology ; Diet ; Fluorocarbons - pharmacology ; Liver - ultrastructure ; Male ; Medical sciences ; Mice ; Mice, Inbred C57BL ; Microbodies - drug effects ; Microbodies - metabolism ; Microbodies - ultrastructure ; Mitochondria, Liver - metabolism ; Mitochondria, Liver - ultrastructure ; Mouse liver ; Oxidation-Reduction ; Oxidoreductases - metabolism ; Palmitoyl Coenzyme A - metabolism ; Perfluorooctanoic acid ; Peroxisome proliferation ; Tumors ; Vitamin A - administration & dosage ; Vitamin A deficiency ; Vitamin A Deficiency - pathology</subject><ispartof>Chemico-biological interactions, 1995-10, Vol.98 (1), p.45-50</ispartof><rights>1995</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-e39954fe081035d28420354f2f1dd97b16cee8531c15b11ec034d68db10d79293</citedby><cites>FETCH-LOGICAL-c452t-e39954fe081035d28420354f2f1dd97b16cee8531c15b11ec034d68db10d79293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0009279795036305$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2889645$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7586050$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sohlenius, Anna-Karin</creatorcontrib><creatorcontrib>Andersson, Karin</creatorcontrib><creatorcontrib>Olsson, Jarl</creatorcontrib><creatorcontrib>DePierre, Joseph W.</creatorcontrib><title>Peroxisome proliferation and associated effects caused by perfluorooctanoic acid in vitamin A-deficient mice</title><title>Chemico-biological interactions</title><addtitle>Chem Biol Interact</addtitle><description>Vitamin A-deficient male mice were treated for 10 days with 0.02% perfluorooctanoic acid (PFOA) in their diet. The effects of this highly potent peroxisome proliferator on peroxisomal palmitoyl-CoA oxidation and lauroyl-CoA oxidase activities were reduced by 3.1–7.5 times in comparision to the values obtained with mice receiving a vitamin A-adequate diet. The activity of peroxisomal catalase was virtually unaffected by vitamin A deficiency and treatment with PFOA had no significant effect on this activity in vitamin A-adequate or vitamin A-deficient mice. However, vitamin A deficiency itself caused a more than 800% increase in cytosolic catalase activity. Thus, the precentage increase caused by PFOA on cytosolic catalase activity was reduced 12.6 times in vitamin A-deficent mice compared to the increase in vitamin A-adequate mice, although the total absolute activities were similar. These findings suggest that the peroxisome proliferation caused by this peroxisome proliferator is highly depedent on the vitamin A status of the mouse.</description><subject>Acyl-CoA Oxidase</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Caprylates - pharmacology</subject><subject>Carcinogenesis, carcinogens and anticarcinogens</subject><subject>Catalase - metabolism</subject><subject>Chemical agents</subject><subject>Cytosol - enzymology</subject><subject>Diet</subject><subject>Fluorocarbons - pharmacology</subject><subject>Liver - ultrastructure</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Microbodies - drug effects</subject><subject>Microbodies - metabolism</subject><subject>Microbodies - ultrastructure</subject><subject>Mitochondria, Liver - metabolism</subject><subject>Mitochondria, Liver - ultrastructure</subject><subject>Mouse liver</subject><subject>Oxidation-Reduction</subject><subject>Oxidoreductases - metabolism</subject><subject>Palmitoyl Coenzyme A - metabolism</subject><subject>Perfluorooctanoic acid</subject><subject>Peroxisome proliferation</subject><subject>Tumors</subject><subject>Vitamin A - administration & dosage</subject><subject>Vitamin A deficiency</subject><subject>Vitamin A Deficiency - pathology</subject><issn>0009-2797</issn><issn>1872-7786</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1rHSEUhqW0pDcf_yAFF6G0i2nU0VE3gRCaJhBoFslaHD2CYWa80ZnQ_Ps6vZe77OrlcJ7zog9C55T8oIR2l4QQ3TCp5TctvpO2a0kjPqANVZI1UqruI9ockM_ouJSXOhLGyRE6kkJ1RJANGh4hpz-xpBHwNqchBsh2jmnCdvLYlpJctDN4DCGAmwt2dil17N_xFnIYlpRTcrOdUnTYuuhxnPBbnO1Y87rxEKKLMM14jA5O0adghwJn-zxBz7c_n27umoffv-5vrh8axwWbG2i1FjwAUZS0wjPFWU0eWKDea9nTzgEo0VJHRU8pONJy3ynfU-KlZro9QV93vfVHrwuU2YyxOBgGO0FaipFSEq7VCvId6HIqJUMw2xxHm98NJWaVbFaDZjVotDD_JBtRz77s-5d-BH842lut-4v93hZnh5Dt5GI5YEwp3fG15mqHQXXxFiGbsrpy4GOuro1P8f_v-AuW4pkD</recordid><startdate>19951020</startdate><enddate>19951020</enddate><creator>Sohlenius, Anna-Karin</creator><creator>Andersson, Karin</creator><creator>Olsson, Jarl</creator><creator>DePierre, Joseph W.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19951020</creationdate><title>Peroxisome proliferation and associated effects caused by perfluorooctanoic acid in vitamin A-deficient mice</title><author>Sohlenius, Anna-Karin ; Andersson, Karin ; Olsson, Jarl ; DePierre, Joseph W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-e39954fe081035d28420354f2f1dd97b16cee8531c15b11ec034d68db10d79293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Acyl-CoA Oxidase</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Caprylates - pharmacology</topic><topic>Carcinogenesis, carcinogens and anticarcinogens</topic><topic>Catalase - metabolism</topic><topic>Chemical agents</topic><topic>Cytosol - enzymology</topic><topic>Diet</topic><topic>Fluorocarbons - pharmacology</topic><topic>Liver - ultrastructure</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Microbodies - drug effects</topic><topic>Microbodies - metabolism</topic><topic>Microbodies - ultrastructure</topic><topic>Mitochondria, Liver - metabolism</topic><topic>Mitochondria, Liver - ultrastructure</topic><topic>Mouse liver</topic><topic>Oxidation-Reduction</topic><topic>Oxidoreductases - metabolism</topic><topic>Palmitoyl Coenzyme A - metabolism</topic><topic>Perfluorooctanoic acid</topic><topic>Peroxisome proliferation</topic><topic>Tumors</topic><topic>Vitamin A - administration & dosage</topic><topic>Vitamin A deficiency</topic><topic>Vitamin A Deficiency - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sohlenius, Anna-Karin</creatorcontrib><creatorcontrib>Andersson, Karin</creatorcontrib><creatorcontrib>Olsson, Jarl</creatorcontrib><creatorcontrib>DePierre, Joseph W.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chemico-biological interactions</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sohlenius, Anna-Karin</au><au>Andersson, Karin</au><au>Olsson, Jarl</au><au>DePierre, Joseph W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Peroxisome proliferation and associated effects caused by perfluorooctanoic acid in vitamin A-deficient mice</atitle><jtitle>Chemico-biological interactions</jtitle><addtitle>Chem Biol Interact</addtitle><date>1995-10-20</date><risdate>1995</risdate><volume>98</volume><issue>1</issue><spage>45</spage><epage>50</epage><pages>45-50</pages><issn>0009-2797</issn><eissn>1872-7786</eissn><coden>CBINA8</coden><abstract>Vitamin A-deficient male mice were treated for 10 days with 0.02% perfluorooctanoic acid (PFOA) in their diet. The effects of this highly potent peroxisome proliferator on peroxisomal palmitoyl-CoA oxidation and lauroyl-CoA oxidase activities were reduced by 3.1–7.5 times in comparision to the values obtained with mice receiving a vitamin A-adequate diet. The activity of peroxisomal catalase was virtually unaffected by vitamin A deficiency and treatment with PFOA had no significant effect on this activity in vitamin A-adequate or vitamin A-deficient mice. However, vitamin A deficiency itself caused a more than 800% increase in cytosolic catalase activity. Thus, the precentage increase caused by PFOA on cytosolic catalase activity was reduced 12.6 times in vitamin A-deficent mice compared to the increase in vitamin A-adequate mice, although the total absolute activities were similar. These findings suggest that the peroxisome proliferation caused by this peroxisome proliferator is highly depedent on the vitamin A status of the mouse.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>7586050</pmid><doi>10.1016/0009-2797(95)03630-5</doi><tpages>6</tpages></addata></record> |
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| subjects | Acyl-CoA Oxidase Animals Biological and medical sciences Caprylates - pharmacology Carcinogenesis, carcinogens and anticarcinogens Catalase - metabolism Chemical agents Cytosol - enzymology Diet Fluorocarbons - pharmacology Liver - ultrastructure Male Medical sciences Mice Mice, Inbred C57BL Microbodies - drug effects Microbodies - metabolism Microbodies - ultrastructure Mitochondria, Liver - metabolism Mitochondria, Liver - ultrastructure Mouse liver Oxidation-Reduction Oxidoreductases - metabolism Palmitoyl Coenzyme A - metabolism Perfluorooctanoic acid Peroxisome proliferation Tumors Vitamin A - administration & dosage Vitamin A deficiency Vitamin A Deficiency - pathology |
| title | Peroxisome proliferation and associated effects caused by perfluorooctanoic acid in vitamin A-deficient mice |
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