Autoreactive T cells in healthy individuals show tolerance in vitro with characteristics similar to but distinct from clonal anergy

Peripheral tolerance to self antigens has been suspected to play an important role in the regulation of the immune response in humans since autoreactive T cells can be isolated from the peripheral blood of healthy individuals. The mechanism of this tolerance is not known, but a number of groups have...

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Veröffentlicht in:	European journal of immunology 1995-11, Vol.25 (11), p.3123-3127
Hauptverfasser:	Filion, Mario C., Bradley, Amanda J., Devine, Dana V., Décary, Francine, Chartrand, Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Autoimmunity - immunology Cell Line Clonal anergy Clonal Anergy - immunology Humans Immune Tolerance - immunology Interferon-gamma - biosynthesis Interleukin-12 - physiology Interleukin-2 - biosynthesis Interleukin-2 - genetics Interleukin-2 - physiology Interleukin-7 - physiology Lymphocyte Activation - immunology Peripheral tolerance Platelet antigen Platelet Glycoprotein GPIIb-IIIa Complex - immunology Receptors, Interleukin-2 - biosynthesis Receptors, Interleukin-2 - genetics RNA Processing, Post-Transcriptional - immunology RNA, Messenger - analysis T-Lymphocytes - immunology T-Lymphocytes - metabolism
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