Cooperativity and Binding in the Mechanism of Cytosolic Phospholipase A2

Cytosolic phospholipase A2 (cPLA2) hydrolyzes the sn-2 ester of phospholipids and is believed to be responsible for the receptor-regulated release of arachidonic acid from phospholipid pools. The enzyme was assayed using vesicles containing arachidonate-containing phospholipid substrate, such as 1-p...

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Veröffentlicht in:	Biochemistry (Easton) 1995-11, Vol.34 (46), p.15165-15174
Hauptverfasser:	Burke, James R, Witmer, Mark R, Tredup, Jeffrey, Micanovic, Radmila, Gregor, Kurt R, Lahiri, Joydeep, Tramposch, Kenneth M, Villafranca, Joseph J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arachidonic Acid - metabolism Baculoviridae - genetics Binding Sites Calcium - pharmacology Cytosol - enzymology Enzyme Stability Glycerol - pharmacology Humans Kinetics Liposomes - chemistry Liposomes - metabolism Mathematics Phosphatidylcholines - metabolism Phosphatidylethanolamines - metabolism Phospholipases A - antagonists & inhibitors Phospholipases A - genetics Phospholipases A - metabolism Phospholipases A2 Phospholipids - metabolism Recombinant Proteins Spodoptera - metabolism Substrate Specificity
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